| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
phthalic acid
phthalic acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7178. phthalic acid : A benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions. | 3.01 | 2 | 0 | benzenedicarboxylic acid | human xenobiotic metabolite |
dibutyl phthalate
Dibutyl Phthalate: A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.. dibutyl phthalate : A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans. | 3.01 | 2 | 0 | diester;
phthalate ester | EC 3.2.1.20 (alpha-glucosidase) inhibitor;
environmental contaminant;
metabolite;
plasticiser;
teratogenic agent |
diethylnitrosamine
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom. | 1.96 | 1 | 0 | nitrosamine | carcinogenic agent;
hepatotoxic agent;
mutagen |
n-nitrosomorpholine
N-nitrosomorpholine : A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco. | 1.96 | 1 | 0 | nitrosamine | carcinogenic agent;
mutagen |
dimethylnitrosamine
Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents. | 1.96 | 1 | 0 | nitrosamine | geroprotector;
mutagen |
di-n-hexyl phthalate
[no description available] | 3.14 | 1 | 0 | 2-hydroxyisophthalic acid | |
n-nitrosodiphenylamine
N-nitrosodiphenylamine: RN given refers to parent cpd; structure in first source | 1.96 | 1 | 0 | phenylhydrazines | |
n-nitrosopiperidine
N-nitrosopiperidine: structure. N-nitrosopiperidine : A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite. | 1.96 | 1 | 0 | nitrosamine;
piperidine | apoptosis inducer;
carcinogenic agent;
environmental contaminant;
mutagen |
diethylhexyl phthalate
Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.. bis(2-ethylhexyl) phthalate : A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid. | 3.01 | 2 | 0 | diester;
phthalate ester | androstane receptor agonist;
apoptosis inhibitor;
plasticiser |
n,n'-dinitrosopiperazine
N,N'-dinitrosopiperazine: RN given refers to unlabeled cpd | 1.96 | 1 | 0 | | |
diisopropylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
n-methyl-n-nitrosoaniline
N-methyl-N-nitrosoaniline: structure | 1.96 | 1 | 0 | | |
n-nitroso(di-n-propyl)amine
[no description available] | 1.96 | 1 | 0 | nitroso compound | |
dibutylnitrosamine
dibutylnitrosamine: structure | 1.96 | 1 | 0 | nitroso compound | |
n-nitrosopyrrolidine
N-Nitrosopyrrolidine: Carcinogenic nitrosamine that may be formed from preservatives in meats during their preparation or in the liver during metabolism. | 1.96 | 1 | 0 | pyrrolidines | |
n-nitrosoperhydroazepine
[no description available] | 1.96 | 1 | 0 | | |
nitrosobenzylmethylamine
nitrosobenzylmethylamine: structure | 1.96 | 1 | 0 | | |
n-nitrosodiethanolamine
[no description available] | 1.96 | 1 | 0 | nitroso compound | |
n-nitroso-2,6-dimethylmorpholine
N-nitroso-2,6-dimethylmorpholine: RN given refers to parent cpd without isomeric designation | 1.96 | 1 | 0 | | |
fluorescein-5-isothiocyanate
Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques. | 2.02 | 1 | 0 | fluorescein isothiocyanate | |
butylhydroxybutylnitrosamine
Butylhydroxybutylnitrosamine: A substituted carcinogenic nitrosamine.. N-butyl-N-(4-hydroxybutyl)nitrosamine : A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues. | 1.96 | 1 | 0 | nitrosamine;
primary alcohol | carcinogenic agent |
n-nitroso-n-methylvinylamine
N-nitroso-N-methylvinylamine: structure given in first source | 1.96 | 1 | 0 | nitroso compound | |
n-nitrosodibenzylamine
N-nitrosodibenzylamine: structure | 1.96 | 1 | 0 | | |
n-nitroso-n-methylcyclohexylamine
[no description available] | 1.96 | 1 | 0 | | |
1-nitrosopiperazine
[no description available] | 1.96 | 1 | 0 | phytanoyl-CoAs | |
nitrosomethyl-n-butylamine
nitrosomethyl-N-butylamine: RN given refers to parent cpd | 1.96 | 1 | 0 | | |
meladrazine
nitrosoproline: RN given refers to 1-nitroso-L-proline | 1.96 | 1 | 0 | | |
methylethylnitrosamine
[no description available] | 1.96 | 1 | 0 | nitroso compound | |
n-ethyl-n-hydroxyethylnitrosamine
N-ethyl-N-(2-hydroxyethyl)nitrosamine : A nitrosamine that is N-nitrosodiethylamine in which one of the ethyl froups has been replaced by a 2-hydroxyethyl group. It is used to induce renal and liver tumours in rodents. | 1.96 | 1 | 0 | nitrosamine;
primary alcohol | carcinogenic agent |
n-amyl-n-methylnitrosamine
N-methyl-N-pentylnitrosamine : A nitrosamine that has methyl and pentyl substituents. It is a potent oesophageal carcinogen. | 1.96 | 1 | 0 | nitrosamine | carcinogenic agent |
vinylethylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
n-nitrososarcosine
N-nitrososarcosine : A nitrosamine that is sarcosine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. | 1.96 | 1 | 0 | nitrosamine;
non-proteinogenic amino acid derivative | carcinogenic agent |
trinitrosotrimethylenetriamine
[no description available] | 1.96 | 1 | 0 | 1,3,5-triazinanes;
nitrosamine | |
diallylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
n-nitroso-n'-methylpiperazine
[no description available] | 1.96 | 1 | 0 | | |
n'-nitrosonornicotine
N'-nitrosonornicotine: structure; a potent carcinogen in laboratory animals | 1.96 | 1 | 0 | pyridines;
pyrrolidines | |
n-nitrosoephedrine
[no description available] | 1.96 | 1 | 0 | | |
n-nitrosoheptamethyleneimine
[no description available] | 1.96 | 1 | 0 | nitrosamine | |
diisopropanolnitrosamine
diisopropanolnitrosamine: experimental carcinogen. N,N-bis(2-hydroxypropyl)nitrosamine : A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney. | 1.96 | 1 | 0 | diol;
nitrosamine;
secondary alcohol | carcinogenic agent |
n-nitrosomethyldodecylamine
N-nitrosomethyldodecylamine: product of reaction of dimethyl-n-dodecylamine with nitrous acid | 1.96 | 1 | 0 | | |
methyl(acetoxymethyl)nitrosamine
methyl(acetoxymethyl)nitrosamine: RN given refers to parent cpd; structure in seventh source | 1.96 | 1 | 0 | | |
nitrosobis(2-oxopropyl)amine
nitrosobis(2-oxopropyl)amine: structure. nitrosobis(2-oxopropyl)amine : A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible). | 1.96 | 1 | 0 | ketone;
nitrosamine | carcinogenic agent |
n-nitrosoguvacoline
N-nitrosoguvacoline: formed by nitrosation of arecoline | 1.96 | 1 | 0 | citraconoyl group | |
n-nitrososarcosine ethyl ester
[no description available] | 1.96 | 1 | 0 | | |
2-hydroxypropyl-n-propylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
2-oxopropyl-n-propylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
3-nitrosomethylaminopyridine
3-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | | |
2-nitrosomethylaminopyridine
2-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | | |
4-nitrosomethylaminopyridine
4-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | | |
n,n-diamylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |