vinylethylnitrosamine profile

Vinylethylnitrosamine (VEN) is a potent carcinogen that has been extensively studied in animal models. It is a volatile, yellow liquid that is readily absorbed through the skin and respiratory tract. VEN is formed by the reaction of N-ethylnitrosamine with vinyl chloride, a process that can occur in industrial settings and in the environment. The compound has been shown to induce tumors in various organs, including the liver, lung, and stomach, in rodents. VEN's carcinogenic potential, coupled with its environmental presence, makes it an important compound for toxicological research. Studies on VEN aim to understand its mechanism of action, identify potential biomarkers of exposure, and develop strategies for its control and prevention. Its research is crucial in evaluating potential risks to human health and developing effective cancer prevention measures.'

ID Source	ID
PubMed CID	25807
CHEMBL ID	165390
SCHEMBL ID	3500931
MeSH ID	M0101964

Synonym
n-ethyl-n-nitrosoethenamine
n-nitrosoethylvinylamine
n-ethenyl-n-ethylnitrosamine
aethyl-vinyl-nitrosoamin [german]
ccris 303
vinylethylnitrosamin [german]
ethenamine, n-ethyl-n-nitroso-
ethenylamine, n-ethyl-n-nitroso-
vinylethylnitrosamine
n-ethyl-n-nitrosovinylamine
vinylamine, n-ethyl-n-nitroso-
ethylvinylnitrosamine
brn 2072075
n-nitroso-n-ethylvinylamine
CHEMBL165390
n-ethenyl-n-ethylnitrous amide
AKOS006276484
13256-13-8
k5th5xts8u ,
unii-k5th5xts8u
vinylethylnitrosamin
aethyl-vinyl-nitrosoamin
SCHEMBL3500931
DTXSID90157618
n-nitroso-ethylvinyl amine
ethenyl-n-ethylnitrosamine, n-
n-ethyl-n-nitroso-ethenamine

Excerpt	Relevance	Reference
" The main target of VEN effect was the respiratory tract where a positive dose-response relationship was established for neoplastic growth."	( Carcinogenicity of vinylethylnitrosamine in Syrian golden hamsters. Althoff, J; Green, U, 1982)	0.59

Assay ID	Title	Year	Journal	Article
AID226732	The compound was modelled in silico for carcinogenic potency; + = Carcinogen	1982	Journal of medicinal chemistry, Jul, Volume: 25, Issue:7	Computer-assisted studies of structure-activity relationships of N-nitroso compounds using pattern recognition.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
diethylnitrosamine Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.	2.65	3	nitrosamine	carcinogenic agent; hepatotoxic agent; mutagen
n-nitrosomorpholine N-nitrosomorpholine : A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.	1.96	1	nitrosamine	carcinogenic agent; mutagen
dimethylnitrosamine Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.	1.96	1	nitrosamine	geroprotector; mutagen
n-nitrosodiphenylamine N-nitrosodiphenylamine: RN given refers to parent cpd; structure in first source	1.96	1	phenylhydrazines
n-nitrosopiperidine N-nitrosopiperidine: structure. N-nitrosopiperidine : A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite.	1.96	1	nitrosamine; piperidine	apoptosis inducer; carcinogenic agent; environmental contaminant; mutagen
n,n'-dinitrosopiperazine N,N'-dinitrosopiperazine: RN given refers to unlabeled cpd	1.96	1
diisopropylnitrosamine [no description available]	1.96	1
n-methyl-n-nitrosoaniline N-methyl-N-nitrosoaniline: structure	1.96	1
n-nitroso(di-n-propyl)amine [no description available]	1.96	1	nitroso compound
dibutylnitrosamine dibutylnitrosamine: structure	1.96	1	nitroso compound
n-nitrosopyrrolidine N-Nitrosopyrrolidine: Carcinogenic nitrosamine that may be formed from preservatives in meats during their preparation or in the liver during metabolism.	1.96	1	pyrrolidines
n-nitrosoperhydroazepine [no description available]	1.96	1
nitrosobenzylmethylamine nitrosobenzylmethylamine: structure	1.96	1
n-nitrosodiethanolamine [no description available]	1.96	1	nitroso compound
n-nitroso-2,6-dimethylmorpholine N-nitroso-2,6-dimethylmorpholine: RN given refers to parent cpd without isomeric designation	1.96	1
butylhydroxybutylnitrosamine Butylhydroxybutylnitrosamine: A substituted carcinogenic nitrosamine.. N-butyl-N-(4-hydroxybutyl)nitrosamine : A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues.	1.96	1	nitrosamine; primary alcohol	carcinogenic agent
n-nitroso-n-methylvinylamine N-nitroso-N-methylvinylamine: structure given in first source	1.96	1	nitroso compound
n-nitrosodibenzylamine N-nitrosodibenzylamine: structure	1.96	1
n-nitroso-n-methylcyclohexylamine [no description available]	1.96	1
1-nitrosopiperazine [no description available]	1.96	1	phytanoyl-CoAs
nitrosomethyl-n-butylamine nitrosomethyl-N-butylamine: RN given refers to parent cpd	1.96	1
meladrazine nitrosoproline: RN given refers to 1-nitroso-L-proline	1.96	1
methylethylnitrosamine [no description available]	1.96	1	nitroso compound
n-ethyl-n-hydroxyethylnitrosamine N-ethyl-N-(2-hydroxyethyl)nitrosamine : A nitrosamine that is N-nitrosodiethylamine in which one of the ethyl froups has been replaced by a 2-hydroxyethyl group. It is used to induce renal and liver tumours in rodents.	1.96	1	nitrosamine; primary alcohol	carcinogenic agent
n-amyl-n-methylnitrosamine N-methyl-N-pentylnitrosamine : A nitrosamine that has methyl and pentyl substituents. It is a potent oesophageal carcinogen.	1.96	1	nitrosamine	carcinogenic agent
n-nitrososarcosine N-nitrososarcosine : A nitrosamine that is sarcosine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group.	1.96	1	nitrosamine; non-proteinogenic amino acid derivative	carcinogenic agent
trinitrosotrimethylenetriamine [no description available]	1.96	1	1,3,5-triazinanes; nitrosamine
diallylnitrosamine [no description available]	1.96	1
n-nitroso-n'-methylpiperazine [no description available]	1.96	1
n'-nitrosonornicotine N'-nitrosonornicotine: structure; a potent carcinogen in laboratory animals	1.96	1	pyridines; pyrrolidines
n-nitrosoephedrine [no description available]	1.96	1
n-nitrosoheptamethyleneimine [no description available]	1.96	1	nitrosamine
diisopropanolnitrosamine diisopropanolnitrosamine: experimental carcinogen. N,N-bis(2-hydroxypropyl)nitrosamine : A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney.	1.96	1	diol; nitrosamine; secondary alcohol	carcinogenic agent
n-nitrosomethyldodecylamine N-nitrosomethyldodecylamine: product of reaction of dimethyl-n-dodecylamine with nitrous acid	1.96	1
n,n-dinitrosohomopiperazine [no description available]	1.96	1
methyl(acetoxymethyl)nitrosamine methyl(acetoxymethyl)nitrosamine: RN given refers to parent cpd; structure in seventh source	1.96	1
nitrosobis(2-oxopropyl)amine nitrosobis(2-oxopropyl)amine: structure. nitrosobis(2-oxopropyl)amine : A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible).	1.96	1	ketone; nitrosamine	carcinogenic agent
n-nitrosoguvacoline N-nitrosoguvacoline: formed by nitrosation of arecoline	1.96	1	citraconoyl group
n-nitrososarcosine ethyl ester [no description available]	1.96	1
2-hydroxypropyl-n-propylnitrosamine [no description available]	1.96	1
2-oxopropyl-n-propylnitrosamine [no description available]	1.96	1
3-nitrosomethylaminopyridine 3-nitrosomethylaminopyridine: structure	1.96	1
2-nitrosomethylaminopyridine 2-nitrosomethylaminopyridine: structure	1.96	1
4-nitrosomethylaminopyridine 4-nitrosomethylaminopyridine: structure	1.96	1
n,n-diamylnitrosamine [no description available]	1.96	1

Condition	Relationship Strength	Studies
Abnormalities, Autosome [description not available]	1.96	1
Experimental Neoplasms [description not available]	1.96	1
Tracheal Neoplasms New abnormal growth of tissue in the TRACHEA.	1.96	1
Delayed Effects, Prenatal Exposure [description not available]	1.96	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.36	2
Cancer of Digestive System [description not available]	1.96	1
Respiratory Tract Neoplasms New abnormal growth of tissue in the RESPIRATORY SYSTEM.	1.96	1
Digestive System Neoplasms Tumors or cancer of the DIGESTIVE SYSTEM.	1.96	1

vinylethylnitrosamine

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Bioassays (1)

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Research Demand Index: 12.66

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