| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
propionaldehyde
propionaldehyde: may cause respiratory irritation; RN given refers to parent cpd; structure. propanal : An aldehyde that consists of ethane bearing a formyl substituent. The parent of the class of propanals. | 1.95 | 1 | 0 | alpha-CH2-containing aldehyde;
propanals | Escherichia coli metabolite |
1-propanol
1-Propanol: A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.. propan-1-ol : The parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group. | 1.95 | 1 | 0 | propan-1-ols;
short-chain primary fatty alcohol | metabolite;
protic solvent |
kojic acid
[no description available] | 2.02 | 1 | 0 | 4-pyranones;
enol;
primary alcohol | Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent |
diethylnitrosamine
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom. | 2.38 | 2 | 0 | nitrosamine | carcinogenic agent;
hepatotoxic agent;
mutagen |
n-nitrosomorpholine
N-nitrosomorpholine : A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco. | 1.96 | 1 | 0 | nitrosamine | carcinogenic agent;
mutagen |
dimethylnitrosamine
Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents. | 1.96 | 1 | 0 | nitrosamine | geroprotector;
mutagen |
n-nitrosodiphenylamine
N-nitrosodiphenylamine: RN given refers to parent cpd; structure in first source | 1.96 | 1 | 0 | phenylhydrazines | |
n-nitrosopiperidine
N-nitrosopiperidine: structure. N-nitrosopiperidine : A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite. | 1.96 | 1 | 0 | nitrosamine;
piperidine | apoptosis inducer;
carcinogenic agent;
environmental contaminant;
mutagen |
n,n'-dinitrosopiperazine
N,N'-dinitrosopiperazine: RN given refers to unlabeled cpd | 1.96 | 1 | 0 | | |
diisopropylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
n-methyl-n-nitrosoaniline
N-methyl-N-nitrosoaniline: structure | 1.96 | 1 | 0 | | |
n-nitroso(di-n-propyl)amine
[no description available] | 2.36 | 2 | 0 | nitroso compound | |
dibutylnitrosamine
dibutylnitrosamine: structure | 1.96 | 1 | 0 | nitroso compound | |
n-nitrosopyrrolidine
N-Nitrosopyrrolidine: Carcinogenic nitrosamine that may be formed from preservatives in meats during their preparation or in the liver during metabolism. | 1.96 | 1 | 0 | pyrrolidines | |
n-nitrosoperhydroazepine
[no description available] | 1.96 | 1 | 0 | | |
nitrosobenzylmethylamine
nitrosobenzylmethylamine: structure | 1.96 | 1 | 0 | | |
n-nitrosodiethanolamine
[no description available] | 1.96 | 1 | 0 | nitroso compound | |
n-nitroso-2,6-dimethylmorpholine
N-nitroso-2,6-dimethylmorpholine: RN given refers to parent cpd without isomeric designation | 1.96 | 1 | 0 | | |
butylhydroxybutylnitrosamine
Butylhydroxybutylnitrosamine: A substituted carcinogenic nitrosamine.. N-butyl-N-(4-hydroxybutyl)nitrosamine : A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues. | 1.96 | 1 | 0 | nitrosamine;
primary alcohol | carcinogenic agent |
n-nitroso-n-methylvinylamine
N-nitroso-N-methylvinylamine: structure given in first source | 1.96 | 1 | 0 | nitroso compound | |
n-nitrosodibenzylamine
N-nitrosodibenzylamine: structure | 1.96 | 1 | 0 | | |
n-nitroso-n-methylcyclohexylamine
[no description available] | 1.96 | 1 | 0 | | |
1-nitrosopiperazine
[no description available] | 1.96 | 1 | 0 | phytanoyl-CoAs | |
nitrosomethyl-n-butylamine
nitrosomethyl-N-butylamine: RN given refers to parent cpd | 1.96 | 1 | 0 | | |
meladrazine
nitrosoproline: RN given refers to 1-nitroso-L-proline | 1.96 | 1 | 0 | | |
methylethylnitrosamine
[no description available] | 1.96 | 1 | 0 | nitroso compound | |
n-ethyl-n-hydroxyethylnitrosamine
N-ethyl-N-(2-hydroxyethyl)nitrosamine : A nitrosamine that is N-nitrosodiethylamine in which one of the ethyl froups has been replaced by a 2-hydroxyethyl group. It is used to induce renal and liver tumours in rodents. | 1.96 | 1 | 0 | nitrosamine;
primary alcohol | carcinogenic agent |
n-amyl-n-methylnitrosamine
N-methyl-N-pentylnitrosamine : A nitrosamine that has methyl and pentyl substituents. It is a potent oesophageal carcinogen. | 1.96 | 1 | 0 | nitrosamine | carcinogenic agent |
vinylethylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
n-nitrososarcosine
N-nitrososarcosine : A nitrosamine that is sarcosine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. | 1.96 | 1 | 0 | nitrosamine;
non-proteinogenic amino acid derivative | carcinogenic agent |
trinitrosotrimethylenetriamine
[no description available] | 1.96 | 1 | 0 | 1,3,5-triazinanes;
nitrosamine | |
diallylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
n-nitroso-n'-methylpiperazine
[no description available] | 1.96 | 1 | 0 | | |
n'-nitrosonornicotine
N'-nitrosonornicotine: structure; a potent carcinogen in laboratory animals | 1.96 | 1 | 0 | pyridines;
pyrrolidines | |
n-nitrosoephedrine
[no description available] | 1.96 | 1 | 0 | | |
n-nitrosoheptamethyleneimine
[no description available] | 1.96 | 1 | 0 | nitrosamine | |
diisopropanolnitrosamine
diisopropanolnitrosamine: experimental carcinogen. N,N-bis(2-hydroxypropyl)nitrosamine : A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney. | 1.96 | 1 | 0 | diol;
nitrosamine;
secondary alcohol | carcinogenic agent |
n-nitrosomethyldodecylamine
N-nitrosomethyldodecylamine: product of reaction of dimethyl-n-dodecylamine with nitrous acid | 1.96 | 1 | 0 | | |
n,n-dinitrosohomopiperazine
[no description available] | 1.96 | 1 | 0 | | |
methyl(acetoxymethyl)nitrosamine
methyl(acetoxymethyl)nitrosamine: RN given refers to parent cpd; structure in seventh source | 1.96 | 1 | 0 | | |
nitrosobis(2-oxopropyl)amine
nitrosobis(2-oxopropyl)amine: structure. nitrosobis(2-oxopropyl)amine : A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible). | 2.36 | 2 | 0 | ketone;
nitrosamine | carcinogenic agent |
n-nitrosoguvacoline
N-nitrosoguvacoline: formed by nitrosation of arecoline | 1.96 | 1 | 0 | citraconoyl group | |
n-nitrososarcosine ethyl ester
[no description available] | 1.96 | 1 | 0 | | |
2-oxopropyl-n-propylnitrosamine
[no description available] | 2.66 | 3 | 0 | | |
3-nitrosomethylaminopyridine
3-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | | |
2-nitrosomethylaminopyridine
2-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | | |
4-nitrosomethylaminopyridine
4-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | | |
n,n-diamylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
guanine
[no description available] | 2 | 1 | 0 | 2-aminopurines;
oxopurine;
purine nucleobase | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
7-methylguanine
7-methylguanine: RN given refers to unlabeled cpd; structure. 7-methylguanine : A methylguanine that is guanine substituted by a methyl group at position 7. It is a metabolite obtained during the methylation of DNA.. 2-imino-7-methyl-1,2,3,7-tetrahydro-6H-purin-6-one : A 7-methylguanine that is 1,2,3,7-tetrahydro-6H-purin-6-one substituted by an imino group at position 2 and a methyl group at position 7.. 2-amino-7-methyl-7H-purin-6-ol : A 7-methylguanine that is 7H-purine substituted by an amino group at position 2, a methyl group at position 7 and a hydroxy group at position 6.. 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one : A 7-methylguanine that is 1,7-dihydro-6H-purin-6-one substituted by an amino group at position 2 and a methyl group at position 7. | 2 | 1 | 0 | 7-methylguanine | |