n-nitrosomethyldodecylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-nitrosomethyldodecylamine: product of reaction of dimethyl-n-dodecylamine with nitrous acid [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	41320
CHEMBL ID	349137
SCHEMBL ID	2932800
MeSH ID	M0055002

Synonyms (31)

Synonym
55090-44-3
n-methyl-n-nitrosododecan-1-amine
n-nitroso-n-methyl-n-dodecylamine
n-nitroso-n-methyl-n-dodecylamin [german]
ccris 1132
dodecylamine, n-methyl-n-nitroso-
nitrosomethyl-n-dodecylamine
n-dodecyl-n-methylnitrosamine
n-methyl-n-nitroso-1-dodecanamine
brn 2251135
n-methyl-n-nitrosolaurylamine
nmdda
laurylamine, n-methyl-n-nitroso-
n-nitrosomethyldodecylamine
n-dodecyl-n-methylnitrous amide
methyldodecylnitrosamine
n-methyl-n-dodecylnitrosamine
mdna
CHEMBL349137
FT-0672970
1-dodecanamine, n-methyl-n-nitroso-
unii-uu5mn48qbf
uu5mn48qbf ,
n-nitroso-n-methyl-n-dodecylamin
n-nitrosododecylmethylamine
SCHEMBL2932800
QPUKANZXOGADOB-UHFFFAOYSA-N
1-dodecyl-1-methyl-2-oxohydrazine
DTXSID4021000
AKOS028110651
dodecyl-n-methylnitrosamine, n-

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID226732	The compound was modelled in silico for carcinogenic potency; + = Carcinogen	1982	Journal of medicinal chemistry, Jul, Volume: 25, Issue:7	Computer-assisted studies of structure-activity relationships of N-nitroso compounds using pattern recognition.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	11 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.96

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.96 (24.57)
Research Supply Index	2.48 (2.92)
Research Growth Index	4.45 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.96)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
diethylnitrosamine Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.	2.65	3	nitrosamine	carcinogenic agent; hepatotoxic agent; mutagen
n-nitrosomorpholine N-nitrosomorpholine : A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.	1.96	1	nitrosamine	carcinogenic agent; mutagen
dimethylnitrosamine Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.	2.36	2	nitrosamine	geroprotector; mutagen
n-nitrosodiphenylamine N-nitrosodiphenylamine: RN given refers to parent cpd; structure in first source	1.96	1	phenylhydrazines
n-nitrosopiperidine N-nitrosopiperidine: structure. N-nitrosopiperidine : A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite.	1.96	1	nitrosamine; piperidine	apoptosis inducer; carcinogenic agent; environmental contaminant; mutagen
dicyclohexylamine dicyclohexylamine: potent inhibitor of spermidine synthase; RN given refers to parent cpd	1.96	1	primary aliphatic amine
diethanolamine diethanolamine: RN given refers to parent cpd. diethanolamine : A member of the class of ethanolamines that is ethanolamine having a N-hydroxyethyl substituent.	1.96	1	ethanolamines	human xenobiotic metabolite
n,n'-dinitrosopiperazine N,N'-dinitrosopiperazine: RN given refers to unlabeled cpd	1.96	1
diisopropylnitrosamine [no description available]	1.96	1
n-methyl-n-nitrosoaniline N-methyl-N-nitrosoaniline: structure	1.96	1
nitrosomethylurethane Nitrosomethylurethane: An alkylating carcinogen that produces gastrointestinal and probably lung and nervous system tumors.	1.96	1	carboxylic ester
n-nitroso(di-n-propyl)amine [no description available]	1.96	1	nitroso compound
dibutylnitrosamine dibutylnitrosamine: structure	1.96	1	nitroso compound
n-nitrosopyrrolidine N-Nitrosopyrrolidine: Carcinogenic nitrosamine that may be formed from preservatives in meats during their preparation or in the liver during metabolism.	1.96	1	pyrrolidines
n-nitrosoperhydroazepine [no description available]	1.96	1
nitrosobenzylmethylamine nitrosobenzylmethylamine: structure	1.96	1
n-nitrosodiethanolamine [no description available]	2.36	2	nitroso compound
n-nitroso-2,6-dimethylmorpholine N-nitroso-2,6-dimethylmorpholine: RN given refers to parent cpd without isomeric designation	1.96	1
butylhydroxybutylnitrosamine Butylhydroxybutylnitrosamine: A substituted carcinogenic nitrosamine.. N-butyl-N-(4-hydroxybutyl)nitrosamine : A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues.	1.96	1	nitrosamine; primary alcohol	carcinogenic agent
n-nitroso-n-methylvinylamine N-nitroso-N-methylvinylamine: structure given in first source	1.96	1	nitroso compound
n-nitrosodibenzylamine N-nitrosodibenzylamine: structure	1.96	1
n-nitroso-n-methylcyclohexylamine [no description available]	1.96	1
1-nitrosopiperazine [no description available]	1.96	1	phytanoyl-CoAs
nitrosomethyl-n-butylamine nitrosomethyl-N-butylamine: RN given refers to parent cpd	1.96	1
meladrazine nitrosoproline: RN given refers to 1-nitroso-L-proline	1.96	1
methylethylnitrosamine [no description available]	2.36	2	nitroso compound
n-ethyl-n-hydroxyethylnitrosamine N-ethyl-N-(2-hydroxyethyl)nitrosamine : A nitrosamine that is N-nitrosodiethylamine in which one of the ethyl froups has been replaced by a 2-hydroxyethyl group. It is used to induce renal and liver tumours in rodents.	1.96	1	nitrosamine; primary alcohol	carcinogenic agent
n-amyl-n-methylnitrosamine N-methyl-N-pentylnitrosamine : A nitrosamine that has methyl and pentyl substituents. It is a potent oesophageal carcinogen.	1.96	1	nitrosamine	carcinogenic agent
vinylethylnitrosamine [no description available]	1.96	1
n-nitrososarcosine N-nitrososarcosine : A nitrosamine that is sarcosine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group.	1.96	1	nitrosamine; non-proteinogenic amino acid derivative	carcinogenic agent
trinitrosotrimethylenetriamine [no description available]	1.96	1	1,3,5-triazinanes; nitrosamine
diallylnitrosamine [no description available]	1.96	1
n-nitroso-n'-methylpiperazine [no description available]	1.96	1
n'-nitrosonornicotine N'-nitrosonornicotine: structure; a potent carcinogen in laboratory animals	1.96	1	pyridines; pyrrolidines
n-nitrosoephedrine [no description available]	1.96	1
n-nitrosoheptamethyleneimine [no description available]	1.96	1	nitrosamine
diisopropanolnitrosamine diisopropanolnitrosamine: experimental carcinogen. N,N-bis(2-hydroxypropyl)nitrosamine : A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney.	1.96	1	diol; nitrosamine; secondary alcohol	carcinogenic agent
n,n-dinitrosohomopiperazine [no description available]	1.96	1
methyl(acetoxymethyl)nitrosamine methyl(acetoxymethyl)nitrosamine: RN given refers to parent cpd; structure in seventh source	1.96	1
nitrosobis(2-oxopropyl)amine nitrosobis(2-oxopropyl)amine: structure. nitrosobis(2-oxopropyl)amine : A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible).	1.96	1	ketone; nitrosamine	carcinogenic agent
n-nitrosoguvacoline N-nitrosoguvacoline: formed by nitrosation of arecoline	1.96	1	citraconoyl group
n-nitrososarcosine ethyl ester [no description available]	1.96	1
2-hydroxypropyl-n-propylnitrosamine [no description available]	1.96	1
2-oxopropyl-n-propylnitrosamine [no description available]	1.96	1
3-nitrosomethylaminopyridine 3-nitrosomethylaminopyridine: structure	1.96	1
2-nitrosomethylaminopyridine 2-nitrosomethylaminopyridine: structure	1.96	1
4-nitrosomethylaminopyridine 4-nitrosomethylaminopyridine: structure	1.96	1
n,n-diamylnitrosamine [no description available]	1.96	1

Condition	Relationship Strength	Studies
Adenocarcinoma, Basal Cell [description not available]	1.96	1
Bladder Cancer [description not available]	3.21	6
Cholangioma [description not available]	1.96	1
Experimental Hepatoma [description not available]	1.96	1
Cancer of Lung [description not available]	2.36	2
Experimental Neoplasms [description not available]	2.87	4
Cancer of Nose [description not available]	1.96	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	1.96	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	3.21	6
Carcinoma, Transitional Cell A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.	2.65	3
Adenoma, Bile Duct A benign tumor of the intrahepatic bile ducts.	1.96	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.36	2
Carcinoma, Epidermoid [description not available]	1.96	1
Metaplasia A condition in which there is a change of one adult cell type to another similar adult cell type.	1.96	1
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	1.96	1

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