| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
acetone
methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H). | 1.96 | 1 | 0 | ketone body;
methyl ketone;
propanones;
volatile organic compound | EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent |
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents. | 1.96 | 1 | 0 | sulfoxide;
volatile organic compound | alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger |
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed) | 1.96 | 1 | 0 | monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species | human metabolite |
3-methylcholanthrene
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position. | 1.96 | 1 | 0 | ortho- and peri-fused polycyclic arene | aryl hydrocarbon receptor agonist;
carcinogenic agent |
disulfiram
[no description available] | 1.97 | 1 | 0 | organic disulfide;
organosulfur acaricide | angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
EC 3.1.1.1 (carboxylesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
ferroptosis inducer;
fungicide;
NF-kappaB inhibitor |
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups. | 1.96 | 1 | 0 | barbiturates | anticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative |
diethylnitrosamine
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom. | 1.96 | 1 | 0 | nitrosamine | carcinogenic agent;
hepatotoxic agent;
mutagen |
n-nitrosomorpholine
N-nitrosomorpholine : A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco. | 1.96 | 1 | 0 | nitrosamine | carcinogenic agent;
mutagen |
dimethylnitrosamine
Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents. | 3.21 | 6 | 0 | nitrosamine | geroprotector;
mutagen |
dimethylformamide
Dimethylformamide: A formamide in which the amino hydrogens are replaced by methyl groups.. N,N-dimethylformamide : A member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups. | 1.96 | 1 | 0 | formamides;
volatile organic compound | geroprotector;
hepatotoxic agent;
polar aprotic solvent |
n-nitrosodiphenylamine
N-nitrosodiphenylamine: RN given refers to parent cpd; structure in first source | 1.96 | 1 | 0 | phenylhydrazines | |
n-nitrosopiperidine
N-nitrosopiperidine: structure. N-nitrosopiperidine : A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite. | 1.96 | 1 | 0 | nitrosamine;
piperidine | apoptosis inducer;
carcinogenic agent;
environmental contaminant;
mutagen |
n,n'-dinitrosopiperazine
N,N'-dinitrosopiperazine: RN given refers to unlabeled cpd | 1.96 | 1 | 0 | | |
diisopropylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
n-methyl-n-nitrosoaniline
N-methyl-N-nitrosoaniline: structure | 1.96 | 1 | 0 | | |
n-nitroso(di-n-propyl)amine
[no description available] | 1.96 | 1 | 0 | nitroso compound | |
dibutylnitrosamine
dibutylnitrosamine: structure | 2.37 | 2 | 0 | nitroso compound | |
n-nitrosopyrrolidine
N-Nitrosopyrrolidine: Carcinogenic nitrosamine that may be formed from preservatives in meats during their preparation or in the liver during metabolism. | 1.96 | 1 | 0 | pyrrolidines | |
n-nitrosoperhydroazepine
[no description available] | 1.96 | 1 | 0 | | |
nitrosobenzylmethylamine
nitrosobenzylmethylamine: structure | 2.36 | 2 | 0 | | |
n-nitrosodiethanolamine
[no description available] | 1.96 | 1 | 0 | nitroso compound | |
n-nitroso-2,6-dimethylmorpholine
N-nitroso-2,6-dimethylmorpholine: RN given refers to parent cpd without isomeric designation | 1.96 | 1 | 0 | | |
butylhydroxybutylnitrosamine
Butylhydroxybutylnitrosamine: A substituted carcinogenic nitrosamine.. N-butyl-N-(4-hydroxybutyl)nitrosamine : A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues. | 1.96 | 1 | 0 | nitrosamine;
primary alcohol | carcinogenic agent |
n-nitroso-n-methylvinylamine
N-nitroso-N-methylvinylamine: structure given in first source | 1.96 | 1 | 0 | nitroso compound | |
n-nitrosodibenzylamine
N-nitrosodibenzylamine: structure | 1.96 | 1 | 0 | | |
n-nitroso-n-methylcyclohexylamine
[no description available] | 1.96 | 1 | 0 | | |
1-nitrosopiperazine
[no description available] | 1.96 | 1 | 0 | phytanoyl-CoAs | |
meladrazine
nitrosoproline: RN given refers to 1-nitroso-L-proline | 1.96 | 1 | 0 | | |
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus. | 2.36 | 2 | 0 | dihydrogen | |
methylethylnitrosamine
[no description available] | 2.36 | 2 | 0 | nitroso compound | |
n-ethyl-n-hydroxyethylnitrosamine
N-ethyl-N-(2-hydroxyethyl)nitrosamine : A nitrosamine that is N-nitrosodiethylamine in which one of the ethyl froups has been replaced by a 2-hydroxyethyl group. It is used to induce renal and liver tumours in rodents. | 1.96 | 1 | 0 | nitrosamine;
primary alcohol | carcinogenic agent |
n-amyl-n-methylnitrosamine
N-methyl-N-pentylnitrosamine : A nitrosamine that has methyl and pentyl substituents. It is a potent oesophageal carcinogen. | 2.37 | 2 | 0 | nitrosamine | carcinogenic agent |
vinylethylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
n-nitrososarcosine
N-nitrososarcosine : A nitrosamine that is sarcosine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. | 1.96 | 1 | 0 | nitrosamine;
non-proteinogenic amino acid derivative | carcinogenic agent |
trinitrosotrimethylenetriamine
[no description available] | 1.96 | 1 | 0 | 1,3,5-triazinanes;
nitrosamine | |
diallylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
n-nitroso-n'-methylpiperazine
[no description available] | 1.96 | 1 | 0 | | |
n'-nitrosonornicotine
N'-nitrosonornicotine: structure; a potent carcinogen in laboratory animals | 1.96 | 1 | 0 | pyridines;
pyrrolidines | |
n-nitrosoephedrine
[no description available] | 1.96 | 1 | 0 | | |
n-nitrosoheptamethyleneimine
[no description available] | 1.96 | 1 | 0 | nitrosamine | |
diisopropanolnitrosamine
diisopropanolnitrosamine: experimental carcinogen. N,N-bis(2-hydroxypropyl)nitrosamine : A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney. | 1.96 | 1 | 0 | diol;
nitrosamine;
secondary alcohol | carcinogenic agent |
n-nitrosomethyldodecylamine
N-nitrosomethyldodecylamine: product of reaction of dimethyl-n-dodecylamine with nitrous acid | 1.96 | 1 | 0 | | |
n,n-dinitrosohomopiperazine
[no description available] | 1.96 | 1 | 0 | | |
methyl(acetoxymethyl)nitrosamine
methyl(acetoxymethyl)nitrosamine: RN given refers to parent cpd; structure in seventh source | 2.37 | 2 | 0 | | |
nitrosobis(2-oxopropyl)amine
nitrosobis(2-oxopropyl)amine: structure. nitrosobis(2-oxopropyl)amine : A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible). | 1.96 | 1 | 0 | ketone;
nitrosamine | carcinogenic agent |
n-nitrosoguvacoline
N-nitrosoguvacoline: formed by nitrosation of arecoline | 1.96 | 1 | 0 | citraconoyl group | |
n-nitrososarcosine ethyl ester
[no description available] | 1.96 | 1 | 0 | | |
2-hydroxypropyl-n-propylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
2-oxopropyl-n-propylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
3-nitrosomethylaminopyridine
3-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | | |
2-nitrosomethylaminopyridine
2-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | | |
4-nitrosomethylaminopyridine
4-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | | |
hydroxyl radical
Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent. | 2.05 | 1 | 0 | oxygen hydride;
oxygen radical;
reactive oxygen species | |
fenton's reagent
Fenton's reagent: used for oxidizing sugars & alcohols | 2.05 | 1 | 0 | | |
n,n-diamylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
nadp
[no description available] | 1.96 | 1 | 0 | | |
hypoxanthine
[no description available] | 1.96 | 1 | 0 | nucleobase analogue;
oxopurine;
purine nucleobase | fundamental metabolite |
allopurinol
Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring. | 1.96 | 1 | 0 | nucleobase analogue;
organic heterobicyclic compound | antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger |