Page last updated: 2024-12-06

n-nitroso-n'-methylpiperazine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

N-nitroso-N'-methylpiperazine (NMNP) is a potent carcinogen that has been studied extensively for its potential to cause cancer in humans. It is formed through the reaction of secondary amines with nitrous acid, which can occur under conditions of high temperature and pressure, as well as in the presence of certain bacteria. NMNP has been shown to be carcinogenic in animal studies, and it is thought to exert its carcinogenic effects by damaging DNA. NMNP is also a potent mutagen, meaning that it can cause mutations in DNA, which can lead to cancer. The formation and fate of NMNP in foods has been investigated, with particular interest in its role in meat processing. NMNP is also found in some tobacco products. The presence of NMNP in foods and tobacco products has led to concerns about its potential to contribute to human cancer risk. NMNP is a potent carcinogen and mutagen, and its presence in foods and tobacco products raises concerns about its potential to contribute to human cancer risk.'

Cross-References

ID SourceID
PubMed CID27826
CHEMBL ID164193
SCHEMBL ID11623926
MeSH IDM0063456

Synonyms (37)

Synonym
brn 0117135
n'-methyl-n-nitrosopiperazine
n-nitroso-n'-methylpiperazin [german]
n-methyl-npz
nsc 523886
ccris 1151
einecs 240-409-3
piperazine, 1-methyl-4-nitroso-
n-nitroso-n'-methylpiperazine
n-methylnitrosopiperazine
methylnitrosopiperidine
wln: t6n dntj ano d1
1-nitroso-4-methylpiperazine
n-methyl-n'-nitrosopiperazine
methylpiperazinenitrosamine
1-methyl-4-nitrosopiperazine
nsc-523886
16339-07-4
nsc523886
n-nitroso-n'-methylpiperazin
CHEMBL164193
AKOS006276505
5584mpj7f2 ,
5-23-03-00220 (beilstein handbook reference)
unii-5584mpj7f2
CEAIOKFZXJMDAS-UHFFFAOYSA-N
SCHEMBL11623926
1-methyl-4-nitroso-piperazine
methyl-4-nitrosopiperazine, 1-
DTXSID30167574
AS-60418
Z1198157883
Q27261293
D92907
A937115
1-methyl-4-nitrosopiperazine; 1-nitroso-4-methylpiperazine; n-nitroso-n'-methylpiperazine; nsc 523886;
EN300-25386041
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID226733Carcinogenic potency modelled in silico, (- = non-carcinogen)1982Journal of medicinal chemistry, Jul, Volume: 25, Issue:7
Computer-assisted studies of structure-activity relationships of N-nitroso compounds using pattern recognition.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (80.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.14

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.14 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.31 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.14)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]