Page last updated: 2024-12-11

collinin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

collinin: the active principle of Zanthoxylum spp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Zanthoxylum	genus	A plant genus of the family RUTACEAE. Some members of Zanthoxylum are reclassified from ELEUTHEROCOCCUS, Melicope, and EVODIA. The twigs are used as dental brushing sticks (TOOTHBRUSHING). Most plants that are called Fagara have been reclassified as Zanthoxylum, however some Fagara were reclassified to MELICOPE (also in the Rutacea family) or to GLEDITSIA (a genus in the FABACEAE family).[MeSH]	Rutaceae	A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH]

Cross-References

ID Source	ID
PubMed CID	5316012
CHEMBL ID	306908
MeSH ID	M0528003

Synonyms (11)

Synonym
34465-83-3
NSC31870 ,
collinin
nsc-31870
CHEMBL306908
7-[(2e)-3,7-dimethylocta-2,6-dienoxy]-8-methoxychromen-2-one
7-[[(2e)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-8-methoxy-2h-1-benzopyran-2-one
CS-0143841
HY-N8388
(e)-7-((3,7-dimethylocta-2,6-dien-1-yl)oxy)-8-methoxy-2h-chromen-2-one
AKOS040756361

Research Excerpts

Overview

Collinin is a secondary plant metabolite belonging to the class of geranyloxycoumarins. It is isolated in small amounts from plants of the Rutaceae family.

Excerpt	Reference	Relevance
"Collinin is a geranyloxycoumarins isolated in small amounts from plants of the Rutaceae family. "	( Chemistry and pharmacology of collinin, active principle of Zanthoxylum spp. Curini, M; Epifano, F; Genovese, S; Marcotullio, MC, 2008)	2.08
"Collinin is a secondary plant metabolite belonging to the class of geranyloxycoumarins. "	( Collinin reduces Porphyromonas gingivalis growth and collagenase activity and inhibits the lipopolysaccharide-induced macrophage inflammatory response and osteoclast differentiation and function. Curini, M; Epifano, F; Genovese, S; Grenier, D; Marquis, A; Santos, J, 2013)	3.28

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (20)

Assay ID	Title	Year	Journal	Article
AID1359333	Induction of melanogenesis in mouse Melan-a cells assessed as effect on tanning property at 40 uM after 48 hrs	2018	European journal of medicinal chemistry, May-25, Volume: 152	Natural oxyprenylated coumarins are modulators of melanogenesis.
AID306626	Inhibition of FTase at 100 uM	2007	Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9	Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I.
AID449576	Anticonvulsant activity in mouse at 300 mg/kg, ip after 120 mins by MES test	2009	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18	Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID659716	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 100 uM after 24 hrs by dual-luciferase assay relative to control	2012	Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9	Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID117727	Percent uM/cm**2	2004	Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9	Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins.
AID110864	Inhibitory activity against mouse uM/cm**2 (control=7.0)	2004	Bioorganic & medicinal chemistry letters, May-03, Volume: 14, Issue:9	Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins.
AID659712	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 5 uM after 24 hrs by dual-luciferase assay relative to control	2012	Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9	Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID659711	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 1 uM after 24 hrs by dual-luciferase assay relative to control	2012	Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9	Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID659717	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells after 24 hrs by dual-luciferase assay relative to control	2012	Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9	Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID659715	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 50 uM after 24 hrs by dual-luciferase assay relative to control	2012	Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9	Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID1359332	Cytotoxicity against mouse Melan-a cells assessed as effect on cell viability at <2 uM after 24 to 72 hrs by trypan blue exclusion assay	2018	European journal of medicinal chemistry, May-25, Volume: 152	Natural oxyprenylated coumarins are modulators of melanogenesis.
AID306627	Inhibition of GGTase 1 at 100 uM	2007	Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9	Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I.
AID659713	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 10 uM after 24 hrs by dual-luciferase assay relative to control	2012	Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9	Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID1359334	Inhibition of melanogenesis in mouse Melan-a cells assessed as effect on whitening property at 40 uM after 48 hrs	2018	European journal of medicinal chemistry, May-25, Volume: 152	Natural oxyprenylated coumarins are modulators of melanogenesis.
AID659714	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 25 uM after 24 hrs by dual-luciferase assay relative to control	2012	Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9	Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID659710	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 0.1 uM after 24 hrs by dual-luciferase assay relative to control	2012	Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9	Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.
AID449574	Anticonvulsant activity in mouse at 300 mg/kg, ip after 30 mins by MES test	2009	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18	Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID1357276	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production	2018	European journal of medicinal chemistry, Jun-10, Volume: 153	Recent acquisitions on oxyprenylated secondary metabolites as anti-inflammatory agents.
AID449573	Anticonvulsant activity in mouse at 300 mg/kg, ip after 15 mins by MES test	2009	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18	Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
AID449575	Anticonvulsant activity in mouse at 300 mg/kg, ip after 60 mins by MES test	2009	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18	Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (45.45)	29.6817
2010's	5 (45.45)	24.3611
2020's	1 (9.09)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	23.71 (24.57)
Research Supply Index	2.48 (2.92)
Research Growth Index	4.56 (4.65)
Search Engine Demand Index	23.28 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (23.71)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (18.18%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (81.82%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
coumarin 2H-chromen-2-one: coumarin derivative	2.13	1	coumarins	fluorescent dye; human metabolite; plant metabolite
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.02	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
chenodeoxycholic acid Chenodeoxycholic Acid: A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.. chenodeoxycholic acid : A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.. chenodeoxycholate : Conjugate base of chenodeoxycholic acid; major species at pH 7.3.	2.07	1	bile acid; C24-steroid; dihydroxy-5beta-cholanic acid	human metabolite; mouse metabolite
imperatorin imperatorin: tumor necrosis factor antagonist; furanocoumarin from West African medicinal plant Clausena anisata; structure in Negwer, 5th ed, #3005. imperatorin : A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.	3.68	2	psoralens	EC 3.1.1.7 (acetylcholinesterase) inhibitor; metabolite
azoxymethane Azoxymethane: A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.	2.04	1
isoimperatorin isoimperatorin: tumor necrosis factor antagonist isolated from Glehniae root. isoimperatorin : A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.	2.17	1	psoralens	EC 3.1.1.7 (acetylcholinesterase) inhibitor; metabolite
coumarin 7 coumarin 7: structure in first source	2.13	1
a-130a [no description available]	4.11	4
aurapten aurapten: RN refers to (E)-isomer; structure given in first source. auraptene : A member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties.	4.56	7	coumarins; monoterpenoid	antihypertensive agent; antineoplastic agent; antioxidant; apoptosis inducer; dopaminergic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; gamma-secretase modulator; gastrointestinal drug; hepatoprotective agent; matrix metalloproteinase inhibitor; neuroprotective agent; plant metabolite; PPARalpha agonist; vulnerary
umbelliprenin umbelliprenin: RN given refers to cpd with unspecified isomeric designation	2.17	1	terpene lactone
7-hydroxycoumarin 7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.	2.17	1	hydroxycoumarin	fluorescent probe; food component; plant metabolite
8-geranyloxypsoralen [no description available]	2.17	1	terpene lactone
lacinartin lacinartin: from Zanthoxylum schinifolium; structure in first source	2.78	3
bergamottin bergamottin: constituent of bergamot oil; structure given in first source	2.17	1	furanocoumarin	metabolite
4-hydroxycordoin 4-hydroxycordoin: antibacterial and anti-inflammatory from Lonchocarpus neuroscapha Benth. (Fabaceae); structure in first source. 4-hydroxycordoin : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at position 4 and 2' and a (3-methylbut-2-en-1-yl)oxy group at position 4'. It has been isolated from Lonchocarpus neuroscapha.	2.46	2	aromatic ether; chalcones; polyphenol	anti-inflammatory agent; antibacterial agent; plant metabolite
derricidin derricidin: from Lonchocarpus sericeus; structure in first source	2.05	1	chalcones
o-geranylsinapyl alcohol O-geranylsinapyl alcohol: structure given in first source; isolated from the bark of Fagara rhetza, an Indonesian medicinal plant	2.07	1
5-geranyloxy-7-methoxycoumarin 5-geranyloxy-7-methoxycoumarin: structure in first source	2.17	1	terpene lactone
nelumal a nelumal A: aromatase inhibitor from Ligularia nelumbifolia; structure in first source	2.07	1
4'-geranyloxyferulic acid 4'-geranyloxyferulic acid: a colon cancer chemopreventive agent isolated from grapefruit skin; structure in first source	2.46	2
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	4.28	5	benzenes; hydroxycoumarin; methyl ketone

Condition	Relationship Strength	Studies
Absence Seizure [description not available]	2.05	1
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	2.05	1
Innate Inflammatory Response [description not available]	3.47	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	3.47	2
Pericementitis [description not available]	2.25	1
Microbial Superinvasion [description not available]	2.25	1
Periodontitis Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)	2.25	1
Cancer of Colon [description not available]	2.04	1
Condition, Preneoplastic [description not available]	2.04	1
Colitis Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.	2.04	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.04	1
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	2.04	1
Precancerous Conditions Pathological conditions that tend eventually to become malignant.	2.04	1

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