Page last updated: 2024-11-13

4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone

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Description

4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID21593928
CHEMBL ID225703
CHEBI ID175929
SCHEMBL ID678646
MeSH IDM0479419

Synonyms (16)

Synonym
4'-hydroxy-3',5,6,7,8-pentamethoxyflavone
CHEBI:175929
2-(4-hydroxy-3-methoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
CHEMBL225703 ,
4'-demethylnobiletin
bdbm50412271
SCHEMBL678646
NHMZUDOXUOAEOH-UHFFFAOYSA-N
2-(4-hydroxy-3-methoxyphenyl)-5,6,7,8-tetramethoxy-4h-chromen-4-one
4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone
2-(4-hydroxy-3-methoxyphenyl)-5,6,7,8-tetramethoxy-4h-1-benzopyran-4-one
DTXSID901150358
HY-142066
CS-0373542
4 inverted exclamation marka-demethylnobiletin
34810-62-3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
etherAn organooxygen compound with formula ROR, where R is not hydrogen.
flavonoidsAny organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC50 (µMol)18.62090.00041.877310.0000AID342547
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (55)

Assay IDTitleYearJournalArticle
AID333559Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of 0.1 j/M2 UV light-induced SOS response to alteration in DNA synthesis at 0.6 mM measured by beta-galactosidase activity by2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333557Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated MeIQ-induced SOS response to alteration in DNA synthesis at 0.6 mM measured by beta-galactosidase activity by Um2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333541Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of 0.1 j/M2 UV light-induced SOS response to alteration in DNA synthesis at 0.05 mM measured by beta-galactosidase activity b2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333542Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of furyfuramide-induced SOS response to alteration in DNA synthesis at 0.05 mM measured by beta-galactosidase activity by Umu2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333548Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of furyfuramide-induced SOS response to alteration in DNA synthesis at 0.1 mM measured by beta-galactosidase activity by Umu 2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333561Inhibition of activated Trp-P-1-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene at 0.6 mM2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID724431Growth inhibition of human SRA 01/04 cells at 32 uM after 4 days by Alamar blue assay2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Polymethoxyflavones as agents that prevent formation of cataract: nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells.
AID333533Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of Trp-P-1-induced SOS response to alteration in DNA synthesis measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333552Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of MeIQ-induced SOS response to alteration in DNA synthesis at 0.3 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333530Inhibition of Trp-P-1-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene at 0.6 mM2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID309066Inhibition of LPS-induced COX2 protein expression in mouse RAW264.7 cells at 5 uM after 24 hrs by Western blotting2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333531Inhibition of MeIQ-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene at 0.6 mM2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID309061Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 10 uM after 24 hrs2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333547Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of 0.1 j/M2 UV light-induced SOS response to alteration in DNA synthesis at 0.1 mM measured by beta-galactosidase activity by2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333537Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.05 mM measured by beta-galactosidase activity b2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333528Inhibition of activated MeIQ-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene at 0.6 mM2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID288087Apoptotic activity in HL60 cells after 24 hrs2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
AID309064Inhibition of LPS-induced iNOS protein expression in mouse RAW264.7 cells at 5 uM after 24 hrs by Western blotting2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333543Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.1 mM measured by beta-galactosidase activity by2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333546Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of MeIQ-induced SOS response to alteration in DNA synthesis at 0.1 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333544Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.1 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID309067Inhibition of LPS-induced COX2 protein expression in mouse RAW264.7 cells at 20 uM after 24 hrs by Western blotting2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333550Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.3 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID609402Inhibition of PMA-induced proMMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE analysis2011Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production.
AID309069Inhibition of LPS-induced COX2 gene expression in mouse RAW264.7 cells at 20 uM after 24 hrs by RT-PCR2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333545Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated MeIQ-induced SOS response to alteration in DNA synthesis at 0.1 mM measured by beta-galactosidase activity by Um2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333534Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of MeIQ-induced SOS response to alteration in DNA synthesis measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333549Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.3 mM measured by beta-galactosidase activity by2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333538Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.05 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333554Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of furyfuramide-induced SOS response to alteration in DNA synthesis at 0.3 mM measured by beta-galactosidase activity by Umu 2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333540Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of MeIQ-induced SOS response to alteration in DNA synthesis at 0.05 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333558Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of MeIQ-induced SOS response to alteration in DNA synthesis at 0.6 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333553Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of 0.1 j/M2 UV light-induced SOS response to alteration in DNA synthesis at 0.3 mM measured by beta-galactosidase activity by2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID635947Inhibition of PMA-stimulated pro MMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE based gelatin zymography assay2011Bioorganic & medicinal chemistry, Dec-01, Volume: 19, Issue:23
B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.
AID288086Antiproliferative activity against HL60 after 24 hrs2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
AID333529Inhibition of MeIQ-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID309062Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 30 uM after 24 hrs2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID309068Inhibition of LPS-induced iNOS gene expression in mouse RAW264.7 cells at 20 uM after 24 hrs by RT-PCR2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333539Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated MeIQ-induced SOS response to alteration in DNA synthesis at 0.05 mM measured by beta-galactosidase activity by U2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333535Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of 0.1 j/M2 UV light-induced SOS response to alteration in DNA synthesis measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333555Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.6 mM measured by beta-galactosidase activity by2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333560Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of furyfuramide-induced SOS response to alteration in DNA synthesis at 0.6 mM measured by beta-galactosidase activity by Umu 2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID309063Cytotoxicity against mouse RAW264.7 cells at 30 uM by MTT assay2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333563Inhibition of activated Trp-P-1-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333562Inhibition of activated MeIQ-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333536Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of furyfuramide-induced SOS response to alteration in DNA synthesis measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID288088Cytotoxicity against human PMN cells at 100 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
AID333551Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated MeIQ-induced SOS response to alteration in DNA synthesis at 0.3 mM measured by beta-galactosidase activity by Um2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID309065Inhibition of LPS-induced iNOS protein expression in mouse RAW264.7 cells at 20 uM after 24 hrs by Western blotting2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID342547Inhibition of rat lens aldose reductase2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
QSAR prediction of inhibition of aldose reductase for flavonoids.
AID635945Inhibition of TNFalpha-stimulated pro MMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE based gelatin zymography assay2011Bioorganic & medicinal chemistry, Dec-01, Volume: 19, Issue:23
B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.
AID333556Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.6 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID609403Inhibition of TNF-alpha-induced proMMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE analysis2011Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production.
AID333532Inhibition of furyfuramide-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene at 0.6 mM2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333527Inhibition of Trp-P-1-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene2004Journal of natural products, Nov, Volume: 67, Issue:11
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (46.67)29.6817
2010's7 (46.67)24.3611
2020's1 (6.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.78 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.56 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]