Compounds > 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone
Page last updated: 2024-08-03 08:03:46

4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone

Description

4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone: structure in first source [MeSH]

4'-Hydroxy-3',5,6,7,8-pentamethoxyflavone : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID21593928
CHEMBL ID225703
SCHEMBL ID678646
CHEBI ID175929
MeSH IDM0479419

Synonyms (16)

Synonym
4'-hydroxy-3',5,6,7,8-pentamethoxyflavone
CHEBI:175929
2-(4-hydroxy-3-methoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
CHEMBL225703 ,
4'-demethylnobiletin
bdbm50412271
SCHEMBL678646
NHMZUDOXUOAEOH-UHFFFAOYSA-N
2-(4-hydroxy-3-methoxyphenyl)-5,6,7,8-tetramethoxy-4h-chromen-4-one
4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone
2-(4-hydroxy-3-methoxyphenyl)-5,6,7,8-tetramethoxy-4h-1-benzopyran-4-one
DTXSID901150358
HY-142066
CS-0373542
4 inverted exclamation marka-demethylnobiletin
34810-62-3

Drug Classes (2)

ClassDescription
etherAn organooxygen compound with formula ROR, where R is not hydrogen.
flavonoidsAny organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them.

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC5018.6209AID342547

Bioassays (55)

Assay IDTitleYearJournalArticle
AID333559Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of 0.1 j/M2 UV light-induced SOS response to alteration in DNA synthesis at 0.6 mM measured by beta-galactosidase activity by2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333557Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated MeIQ-induced SOS response to alteration in DNA synthesis at 0.6 mM measured by beta-galactosidase activity by Um2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333541Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of 0.1 j/M2 UV light-induced SOS response to alteration in DNA synthesis at 0.05 mM measured by beta-galactosidase activity b2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333542Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of furyfuramide-induced SOS response to alteration in DNA synthesis at 0.05 mM measured by beta-galactosidase activity by Umu2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333548Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of furyfuramide-induced SOS response to alteration in DNA synthesis at 0.1 mM measured by beta-galactosidase activity by Umu 2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333561Inhibition of activated Trp-P-1-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene at 0.6 mM2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID724431Growth inhibition of human SRA 01/04 cells at 32 uM after 4 days by Alamar blue assay2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
ISSN: 1464-3405		Polymethoxyflavones as agents that prevent formation of cataract: nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells.
AID333533Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of Trp-P-1-induced SOS response to alteration in DNA synthesis measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333552Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of MeIQ-induced SOS response to alteration in DNA synthesis at 0.3 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333530Inhibition of Trp-P-1-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene at 0.6 mM2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID309066Inhibition of LPS-induced COX2 protein expression in mouse RAW264.7 cells at 5 uM after 24 hrs by Western blotting2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
ISSN: 0960-894X		Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333531Inhibition of MeIQ-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene at 0.6 mM2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID309061Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 10 uM after 24 hrs2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
ISSN: 0960-894X		Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333547Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of 0.1 j/M2 UV light-induced SOS response to alteration in DNA synthesis at 0.1 mM measured by beta-galactosidase activity by2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333537Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.05 mM measured by beta-galactosidase activity b2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333528Inhibition of activated MeIQ-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene at 0.6 mM2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID288087Apoptotic activity in HL60 cells after 24 hrs2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
ISSN: 0968-0896		Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
AID309064Inhibition of LPS-induced iNOS protein expression in mouse RAW264.7 cells at 5 uM after 24 hrs by Western blotting2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
ISSN: 0960-894X		Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333543Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.1 mM measured by beta-galactosidase activity by2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333546Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of MeIQ-induced SOS response to alteration in DNA synthesis at 0.1 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333544Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.1 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID309067Inhibition of LPS-induced COX2 protein expression in mouse RAW264.7 cells at 20 uM after 24 hrs by Western blotting2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
ISSN: 0960-894X		Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333550Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.3 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID609402Inhibition of PMA-induced proMMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE analysis2011Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
ISSN: 1464-3405		Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production.
AID309069Inhibition of LPS-induced COX2 gene expression in mouse RAW264.7 cells at 20 uM after 24 hrs by RT-PCR2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
ISSN: 0960-894X		Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333545Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated MeIQ-induced SOS response to alteration in DNA synthesis at 0.1 mM measured by beta-galactosidase activity by Um2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333534Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of MeIQ-induced SOS response to alteration in DNA synthesis measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333549Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.3 mM measured by beta-galactosidase activity by2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333538Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.05 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333554Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of furyfuramide-induced SOS response to alteration in DNA synthesis at 0.3 mM measured by beta-galactosidase activity by Umu 2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333540Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of MeIQ-induced SOS response to alteration in DNA synthesis at 0.05 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333558Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of MeIQ-induced SOS response to alteration in DNA synthesis at 0.6 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333553Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of 0.1 j/M2 UV light-induced SOS response to alteration in DNA synthesis at 0.3 mM measured by beta-galactosidase activity by2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID635947Inhibition of PMA-stimulated pro MMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE based gelatin zymography assay2011Bioorganic & medicinal chemistry, Dec-01, Volume: 19, Issue:23
ISSN: 1464-3391		B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.
AID288086Antiproliferative activity against HL60 after 24 hrs2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
ISSN: 0968-0896		Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
AID333529Inhibition of MeIQ-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID309062Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 30 uM after 24 hrs2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
ISSN: 0960-894X		Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID309068Inhibition of LPS-induced iNOS gene expression in mouse RAW264.7 cells at 20 uM after 24 hrs by RT-PCR2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
ISSN: 0960-894X		Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333539Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated MeIQ-induced SOS response to alteration in DNA synthesis at 0.05 mM measured by beta-galactosidase activity by U2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333535Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of 0.1 j/M2 UV light-induced SOS response to alteration in DNA synthesis measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333555Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.6 mM measured by beta-galactosidase activity by2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333560Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of furyfuramide-induced SOS response to alteration in DNA synthesis at 0.6 mM measured by beta-galactosidase activity by Umu 2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID309063Cytotoxicity against mouse RAW264.7 cells at 30 uM by MTT assay2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
ISSN: 0960-894X		Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID333563Inhibition of activated Trp-P-1-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333562Inhibition of activated MeIQ-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333536Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of furyfuramide-induced SOS response to alteration in DNA synthesis measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID288088Cytotoxicity against human PMN cells at 100 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
ISSN: 0968-0896		Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
AID333551Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of activated MeIQ-induced SOS response to alteration in DNA synthesis at 0.3 mM measured by beta-galactosidase activity by Um2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID309065Inhibition of LPS-induced iNOS protein expression in mouse RAW264.7 cells at 20 uM after 24 hrs by Western blotting2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
ISSN: 0960-894X		Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.
AID342547Inhibition of rat lens aldose reductase2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
ISSN: 1464-3391		QSAR prediction of inhibition of aldose reductase for flavonoids.
AID635945Inhibition of TNFalpha-stimulated pro MMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE based gelatin zymography assay2011Bioorganic & medicinal chemistry, Dec-01, Volume: 19, Issue:23
ISSN: 1464-3391		B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.
AID333556Antimutagenic activity in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene assessed as suppression of Trp-P-1-induced SOS response to alteration in DNA synthesis at 0.6 mM measured by beta-galactosidase activity by Umu test2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID609403Inhibition of TNF-alpha-induced proMMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE analysis2011Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
ISSN: 1464-3405		Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production.
AID333532Inhibition of furyfuramide-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene at 0.6 mM2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
AID333527Inhibition of Trp-P-1-induced SOS response to alteration in DNA synthesis in Salmonella Typhimurium TA1535 carrying pSK1002 containing umuC'-lacZ fused gene2004Journal of natural products, Nov, Volume: 67, Issue:11
ISSN: 0163-3864		Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (46.67)29.6817
2010's7 (46.67)24.3611
2020's1 (6.67)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
acebutolol
0
aromatic amide;
ethanolamines;
ether;
monocarboxylic acid amide;
propanolamine;
secondary amino compound		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympathomimetic agent		00low000000
cetirizine
0
ether;
monocarboxylic acid;
monochlorobenzenes;
piperazines		anti-allergic agent;
environmental contaminant;
H1-receptor antagonist;
xenobiotic		00low000000
dimefline
0
ether;
flavonoids		00low000000
diphenhydramine
0
ether;
tertiary amino compound		anti-allergic agent;
antidyskinesia agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
antitussive;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
oneirogen;
sedative		00low000000
econazole
0
dichlorobenzene;
ether;
imidazoles;
monochlorobenzenes		00low000000
enflurane
0
ether;
organochlorine compound;
organofluorine compound		anaesthetic00low000000
eprazinone
0
aromatic ketone;
ether;
N-alkylpiperazine		mucolytic00low000000
ether
0
ether;
volatile organic compound		inhalation anaesthetic;
non-polar solvent;
refrigerant		00low000000
vanoxerine
0
ether;
N-alkylpiperazine;
organofluorine compound;
tertiary amino compound		dopamine uptake inhibitor00low000000
gbr 12935
0
ether;
N-alkylpiperazine;
tertiary amino compound		dopamine uptake inhibitor00low000000
hesperetin
0
ether;
flavonoids		00low000000
isoconazole
0
dichlorobenzene;
ether;
imidazoles		00low000000
ketoconazole
0
dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine		00low000000
methoxyflurane
0
ether;
organochlorine compound;
organofluorine compound		hepatotoxic agent;
inhalation anaesthetic;
nephrotoxic agent;
non-narcotic analgesic		00low000000
metolachlor
0
aromatic amide;
benzenes;
ether;
organochlorine compound		00low000000
miconazole
0
dichlorobenzene;
ether;
imidazoles		00low000000
orphenadrine
0
ether;
tertiary amino compound		antidyskinesia agent;
antiparkinson drug;
H1-receptor antagonist;
muscarinic antagonist;
muscle relaxant;
NMDA receptor antagonist;
parasympatholytic		00low000000
salmeterol xinafoate
0
ether;
phenols;
primary alcohol;
secondary alcohol;
secondary amino compound		00low000000
sevoflurane
0
ether;
organofluorine compound		central nervous system depressant;
inhalation anaesthetic;
platelet aggregation inhibitor		00low000000
tioconazole
0
dichlorobenzene;
ether;
imidazoles;
thiophenes		00low000000
chloromethyl methyl ether
0
ether00low000000
bis(2-chloro-1-methylethyl) ether
0
ether00low000000
vinyl ether
0
ether00low000000
bis(2-chloroethyl)ether
0
ether00low000000
butyl carbitol
0
ether00low000000
dimethyl ether
0
ether00low000000
flurothyl
0
ether00low000000
bis(chloromethyl) ether
0
ether;
organochlorine compound		alkylating agent;
carcinogenic agent		00low000000
methoxyacetic acid
0
ether;
monocarboxylic acid		antineoplastic agent;
apoptosis inducer;
human xenobiotic metabolite;
mutagen		00low000000
ethyl tert-butyl ether
0
ether;
volatile organic compound		fuel additive00low000000
methyl tert-butyl ether
0
etherfuel additive;
metabolite;
non-polar solvent		00low000000
mitomycin a
0
ether;
mitomycin		alkylating agent;
antimicrobial agent;
antineoplastic agent;
toxin		00low000000
ethofumesate
0
1-benzofurans;
ether;
methanesulfonate ester		00low000000
enilconazole
0
dichlorobenzene;
ether;
imidazoles		00low000000
sufentanil
0
anilide;
ether;
piperidines;
thiophenes		anaesthesia adjuvant;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic		00low000000
metalaxyl
0
alanine derivative;
aromatic amide;
carboxamide;
ether;
methyl ester		00low000000
fenticonazole
0
aryl sulfide;
dichlorobenzene;
ether;
imidazoles		00low000000
oxadixyl
0
anilide fungicide;
aromatic amide;
carbohydrazide;
ether;
oxazolidinone		agrochemical00low000000
adefovir
0
6-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent		00low000000
adefovir dipivoxil
0
6-aminopurines;
carbonate ester;
ether;
organic phosphonate		antiviral drug;
DNA synthesis inhibitor;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent;
prodrug		00low000000
sertaconazole
0
1-benzothiophenes;
dichlorobenzene;
ether;
imidazoles		00low000000
4'-methoxyflavone
0
ether;
flavonoids		00low000000
5,7,4'-trimethylapigenin
0
ether;
flavonoids		00low000000
tetraconazole
0
dichlorobenzene;
ether;
organofluorine compound;
triazoles		00low000000
raptors
0
ether;
imidazolines;
imidazolone;
pyridinemonocarboxylic acid		00low000000
dimethenamid
0
aromatic amide;
ether;
organochlorine compound;
thiophenes		00low000000
5-Methoxyflavone
0
ether;
flavonoids		00low000000
cellulose sulfate
0
ether;
flavonoids		00low000000
2'-o-methyladenosine
0
adenosines;
ether		fungal metabolite00low000000
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole
0
ether;
imidazoles;
monomethoxybenzene		TRP channel blocker00low000000
5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone
0
ether;
flavonoids		00low000000
2'-methoxyflavone
0
ether;
flavonoids		00low000000
6-methoxyflavone
0
ether;
flavonoids		00low000000
3,3',4',5,6,7,8-heptamethoxyflavone
0
ether;
flavonoids		00low000000
sideritoflavone
0
ether;
flavonoids		00low000000
3'-demethylnobiletin
0
ether;
flavonoids		00low000000
3',4',5'-trimethoxyflavone
0
ether;
flavonoids		00low000000
5-demethylnobiletin
0
ether;
flavonoids		00low000000
5-Hydroxy-7-methoxy-6-methylflavone
0
ether;
flavonoids		00low000000
5,7-dimethoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one
0
ether;
flavonoids		00low000000
7-methoxyflavone
0
ether;
flavonoids		00low000000
negletein
0
ether;
flavonoids		00low000000
5-hydroxy-6,7-dimethoxyflavone
0
ether;
flavonoids		00low000000
zapotin
0
ether;
flavonoids		00low000000
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one
0
ether;
flavonoids		00low000000
6-methoxy-2-(3-methoxyphenyl)-1-benzopyran-4-one
0
ether;
flavonoids		00low000000
3,7-dimethoxyflavone
0
ether;
flavonoids		00low000000
6-methoxy-2-(4-methoxyphenyl)-1-benzopyran-4-one
0
ether;
flavonoids		00low000000
N-(2-ethylphenyl)-2-[[2-(4-methoxyphenyl)-4-oxo-1-benzopyran-6-yl]oxy]acetamide
0
ether;
flavonoids		00low000000
o-methyl threonine
0
ether;
L-threonine derivative;
non-proteinogenic L-alpha-amino acid		antibacterial agent;
bleaching agent		00low000000
6,3',4'-Trimethoxyflavanone
0
ether;
flavonoids		00low000000
demethoxysudachitin
0
ether;
flavonoids		00low000000
2-[[2-(4-methoxyphenyl)-6-methyl-1-benzopyran-4-ylidene]amino]-4-methylpentanoic acid
0
ether;
flavonoids		00low000000
2-[[2-(3,4-dimethoxyphenyl)-6-methyl-1-benzopyran-4-ylidene]amino]butanoic acid
0
ether;
flavonoids		00low000000
alpinetin
0
ether;
flavonoids		00low000000
7-methoxy-2-(4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
0
ether;
flavonoids		00low000000
mycophenolate mofetil
0
carboxylic ester;
ether;
gamma-lactone;
phenols;
tertiary amino compound		anticoronaviral agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
immunosuppressive agent;
prodrug		00low000000
soraphen a
0
cyclic hemiketal;
ether;
macrolide;
olefinic compound		bacterial metabolite;
EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
teratogenic agent		00low000000
l 683590
0
ether;
lactol;
macrolide;
secondary alcohol		antifungal agent;
bacterial metabolite;
immunosuppressive agent		00low000000
acetylspiramycin
0
acetate ester;
aldehyde;
disaccharide derivative;
ether;
macrolide;
tertiary amino compound		antibacterial drug;
antimicrobial agent;
bacterial metabolite		00low000000
sirolimus
0
antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor		00low000000
hydroxygenkwanin
0
ether;
flavonoids		00low000000
Kumatakenin
0
ether;
flavonoids		00low000000
artemetin
0
ether;
flavonoids		00low000000
ternatin (flavonoid)
0
ether;
flavonoids		00low000000
oripavine
0
ether;
morphinane alkaloid;
organic heteropentacyclic compound;
organic hydroxy compound;
tertiary amino compound		bacterial xenobiotic metabolite;
opioid analgesic		00low000000
bongkrekic acid
0
ether;
olefinic compound;
tricarboxylic acid		apoptosis inhibitor;
ATP/ADP translocase inhibitor;
bacterial metabolite;
EC 2.5.1.18 (glutathione transferase) inhibitor;
toxin		00low000000
demycarosylturimycin h
0
aldehyde;
disaccharide derivative;
ether;
macrolide;
tertiary amino compound		antibacterial drug;
antimicrobial agent;
bacterial metabolite		00low000000
everolimus
0
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
primary alcohol;
secondary alcohol		anticoronaviral agent;
antineoplastic agent;
geroprotector;
immunosuppressive agent;
mTOR inhibitor		00low000000
l 744832
0
benzenes;
ether;
isopropyl ester;
secondary carboxamide;
sulfone;
thiol		antineoplastic agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
geroprotector		00low000000
pinostrobin
0
ether;
flavonoids		00low000000
gs-7340
0
6-aminopurines;
ether;
isopropyl ester;
L-alanine derivative;
phosphoramidate ester		antiviral drug;
HIV-1 reverse transcriptase inhibitor;
prodrug		00low000000
estin
0
1-benzofurans;
ether;
methyl ester;
organochlorine compound;
oxaspiro compound;
phenols		Aspergillus metabolite;
Penicillium metabolite		00low000000
selexipag
0
aromatic amine;
ether;
monocarboxylic acid amide;
N-sulfonylcarboxamide;
pyrazines;
tertiary amino compound		orphan drug;
platelet aggregation inhibitor;
prodrug;
prostacyclin receptor agonist;
vasodilator agent		00low000000
mre 269
0
aromatic amine;
ether;
monocarboxylic acid;
pyrazines;
sulfonamide;
tertiary amino compound		drug metabolite;
orphan drug;
platelet aggregation inhibitor;
prostacyclin receptor agonist;
vasodilator agent		00low000000
vilanterol
0
benzyl alcohols;
dichlorobenzene;
ether;
phenols;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent		00low000000
rolapitant
0
azaspiro compound;
ether;
organofluorine compound;
piperidines;
pyrrolidin-2-ones		antiemetic;
neurokinin-1 receptor antagonist		00low000000
calycopterin
0
ether;
flavonoids		00low000000
iejimalide b
0
ether;
formamides;
macrolide		antineoplastic agent;
marine metabolite		00low000000
migrastatin
0
ether;
macrolide antibiotic;
piperidones;
secondary alcohol		antineoplastic agent;
metabolite		00low000000
5-Hydroxyauranetin
0
ether;
flavonoids		00low000000
episilvestrol
0
dioxanes;
ether;
methyl ester;
organic heterotricyclic compound		antineoplastic agent;
metabolite		00low000000
tembotrione
0
aromatic ketone;
beta-triketone;
cyclic ketone;
ether;
monochlorobenzenes;
organofluorine compound;
sulfone		agrochemical;
carotenoid biosynthesis inhibitor;
EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor;
herbicide		00low000000
silvestrol
0
dioxanes;
ether;
methyl ester;
organic heterotricyclic compound		antineoplastic agent;
metabolite		00low000000
cytotrienin a
0
cyclopropanecarboxylate ester;
ether;
hydroquinones;
lactam;
macrocycle;
secondary alcohol		antibacterial agent;
antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
metabolite		00low000000
sudachitin
0
ether;
flavonoids		00low000000
nodularin
0
ether00low000000
debromoaplysiatoxin
0
aplysiatoxins;
cyclic hemiketal;
ether;
organic heterotricyclic compound;
phenols;
secondary alcohol;
spiroketal		algal metabolite;
carcinogenic agent;
cyanotoxin;
marine metabolite;
protein kinase C agonist		00low000000
aplysiatoxin
0
aplysiatoxins;
bromophenol;
cyclic hemiketal;
ether;
organic heterotricyclic compound;
secondary alcohol;
spiroketal		algal metabolite;
carcinogenic agent;
cyanotoxin;
marine metabolite;
protein kinase C agonist		00low000000
novobiocin
0
carbamate ester;
ether;
hexoside;
hydroxycoumarin;
monocarboxylic acid amide;
monosaccharide derivative;
phenols		antibacterial agent;
antimicrobial agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Escherichia coli metabolite;
hepatoprotective agent		00low000000
gs-5816
0
carbamate ester;
ether;
imidazoles;
L-valine derivative;
N-acylpyrrolidine;
organic heteropentacyclic compound;
ring assembly		antiviral drug;
hepatitis C virus nonstructural protein 5A inhibitor		00low000000
althiomycin
0
1,3-thiazoles;
aldoxime;
ether;
gamma-lactam;
pentapeptide;
peptide antibiotic;
primary alcohol;
pyrroline;
secondary carboxamide;
tertiary carboxamide		antibacterial agent;
bacterial metabolite;
protein synthesis inhibitor		00low000000
marineosin a
0
azaspiro compound;
ether;
macrocycle;
oxaspiro compound;
pyrroles		antineoplastic agent;
metabolite		00low000000
marineosin b
0
azaspiro compound;
ether;
macrocycle;
oxaspiro compound;
pyrroles		antineoplastic agent;
metabolite		00low000000
nepitrin
0
flavonoids;
glycoside		00low000000
cirsimarin
0
flavonoids;
glycoside		00low000000
hidrosmin
0
flavonoids;
glycoside		00low000000
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-8-(3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)-4H-chromen-4-one
0
C-glycosyl compound;
flavonoids		00low000000
6-(5,6-Dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
0
flavonoids;
glucosiduronic acid		00low000000
isovitexin
0
C-glycosyl compound;
flavonoids		00low000000
rutin
0
flavonoids;
glycoside		00low000000
juglanin
0
flavonoids;
glycoside		00low000000
kaempferol 3-o-neohesperidoside
0
flavonoids;
glycoside		00low000000
apigenin-7-o-beta-d-glucuronide
0
flavonoids;
glucosiduronic acid		00low000000
neoisoliquiritin
0
flavonoids;
glycoside		00low000000
Diosmetin rutinoside
0
flavonoids;
glycoside		00low000000
apigenin-7-o-glucuronide
0
flavonoids;
glucosiduronic acid		00low000000
icarrin
0
flavonoids;
glycoside		00low000000
vitexin rhamnoside
0
flavonoids;
glycoside		00low000000
epimedin b
0
flavonoids;
glycoside		00low000000
epimedin c
0
flavonoids;
glycoside		00low000000
hesperidin
0
flavonoids;
glycoside		00low000000
1,5-anhydro-1-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-6-yl]hexitol
0
C-glycosyl compound;
flavonoids		00low000000
marein
0
flavonoids;
glycoside		00low000000
isoliquiritin apioside
0
flavonoids;
glycoside		00low000000
2''-galloylhyperin
0
flavonoids;
glycoside		00low000000
5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]-1-benzopyran-4-one
0
C-glycosyl compound;
flavonoids		00low000000
7-monohydroxyethylrutoside
0
flavonoids;
glycoside		00low000000
sagittatoside b
0
flavonoids;
glycoside		00low000000
Diosmetin 7-O-beta-D-glucopyranoside
0
flavonoids;
glycoside		00low000000
Asebotin
0
flavonoids;
glycoside		00low000000
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-3-yl 6-O-(6-deoxyhexopyranosyl)hexopyranoside
0
flavonoids;
glycoside		00low000000
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-3-yl 2-O-hexopyranosylhexopyranoside
0
flavonoids;
glycoside		00low000000
3'',4''-Diacetylafzelin
0
flavonoids;
glycoside		00low000000
didymin
0
flavonoids;
glycoside		00low000000
multiflorin a
0
flavonoids;
glycoside		00low000000
typhaneoside
0
flavonoids;
glycoside		00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
pedalitin
1
monomethoxyflavone;
tetrahydroxyflavone		EC 1.17.3.2 (xanthine oxidase) inhibitor;
metabolite		2008200816.0low000100
tangeretin
3
pentamethoxyflavoneantineoplastic agent;
plant metabolite		2007201313.7low000120
nobiletin
6
methoxyflavoneantineoplastic agent;
plant metabolite		2004201315.2medium000330
xanthomicrol
3
dihydroxyflavone;
trimethoxyflavone		antineoplastic agent;
plant metabolite		2008201313.3medium000120
gardenin b
1
monohydroxyflavone;
tetramethoxyflavone		plant metabolite2007200717.0low000100
5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone
1
ether;
flavonoids		2007200717.0low000100
sinensetin
1
pentamethoxyflavoneplant metabolite2007200717.0low000100
3,3',4',5,6,7,8-heptamethoxyflavone
1
ether;
flavonoids		2007200717.0low000100
5-hydroxy-3',4',6,7-tetramethoxyflavone
1
2007200717.0low000100
sideritoflavone
1
ether;
flavonoids		2008200816.0high000100
cirsiliol
1
dimethoxyflavone;
trihydroxyflavone		plant metabolite2008200816.0low000100
nevadensin
1
dihydroxyflavone;
trimethoxyflavone		plant metabolite2008200816.0low000100
cirsilineol
1
dihydroxyflavone;
trimethoxyflavone		antineoplastic agent;
plant metabolite		2008200816.0low000100
4',5-dihydroxy-3',6,7,8-tetramethoxyflavone
3
2008201313.3high000120
4',6-dihydroxyflavone
1
dihydroxyflavone2008200816.0medium000100
3'-demethylnobiletin
4
ether;
flavonoids		2007201115.0high000220
cirsimaritin
1
dihydroxyflavone;
dimethoxyflavone		2008200816.0low000100
gardenin a
1
2007200717.0low000100
5-demethylnobiletin
3
ether;
flavonoids		2007201313.7medium000120
demethoxysudachitin
1
ether;
flavonoids		2008200816.0medium000100
natsudaidain
1
hydroxyflavan2007200717.0medium000100
dexmedetomidine
1
trihydroxyflavone;
trimethoxyflavone		antineoplastic agent;
metabolite		2008200816.0low000100
axillarin
1
dimethoxyflavone;
tetrahydroxyflavone		plant metabolite2008200816.0medium000100
6-hydroxyluteolin
1
pentahydroxyflavone2008200816.0medium000100
3',4'-didemethylnobiletin
6
2007201314.5high000330
artemetin
1
ether;
flavonoids		2007200717.0low000100
sudachitin
1
ether;
flavonoids		2008200816.0low000100
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
tetradecanoylphorbol acetate
2
acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator		2007201513.0low000110
atorvastatin
1
aromatic amide;
dihydroxy monocarboxylic acid;
monofluorobenzenes;
pyrroles;
statin (synthetic)		environmental contaminant;
xenobiotic		201820186.0low000010
tangeretin
1
pentamethoxyflavoneantineoplastic agent;
plant metabolite		2007200717.0low000100
nobiletin
8
methoxyflavoneantineoplastic agent;
plant metabolite		2004201812.6medium000440
3'-demethylnobiletin
3
ether;
flavonoids		2006201514.7high000210
furylfuramide
1
acrylamides;
C-nitro compound;
nitrofuran antibiotic;
primary carboxamide		2004200420.0low000100
3',4'-didemethylnobiletin
1
201520159.0low000010
dizocilpine maleate
2
maleate salt;
tetracyclic antidepressant		anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist		2009201711.0low000110
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Age-Related Memory Disorders0
2
2009201711.0low000110
Age-Related Osteoporosis0
1
202320231.0low000001
Amentia0
1
201720177.0low000010
Anasarca0
1
201520159.0low000010
Bone Loss, Osteoclastic0
1
202320231.0low000001
Cancer of Colon0
2
201520187.5low000020
Cataract0
1
2013201311.0low000010
Cataract, Membranous0
1
2013201311.0low000010
Colitis0
1
201520159.0low000010
Colonic Neoplasms0
2
201520187.5low000020
Contact Dermatitis0
1
201520159.0low000010
Dementia0
1
201720177.0low000010
Dermatitis0
1
201520159.0low000010
Dermatitis, Contact0
1
201520159.0low000010
Edema0
1
201520159.0low000010
Experimental Neoplasms0
1
201520159.0low000010
Memory Disorders0
2
2009201711.0low000110
Osteoporosis0
1
202320231.0low000001