Double Nuchal Cord

A complication of pregnancy in which the UMBILICAL CORD wraps around the fetal neck once or multiple times. In some cases, cord entanglement around fetal neck may not affect pregnancy outcome significantly. In others, the nuchal cord may lead to restricted fetal blood flow, oxygen transport, fetal development, fetal movement, and complicated delivery at birth.

Synonym
Double Nuchal Cord
Quadruple Nuchal Cord
Fetal Cord Entanglement
Single Nuchal Cord
Triple Nuchal Cord
Nuchal Cord

Excerpt	Reference
"To examine whether nuchal cord affects fetal lipid peroxidation and cord arterial blood gases, and thus to determine whether lipid peroxidation can show intrapartum distress."	( Bukan, N; Kurdoglu, M; Onan, A; Sancak, B; Yildirim, M, 2009)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	1 (9.09)	18.1394
2010's	9 (81.82)	28.8240
2020's	1 (9.09)	9.53

Drug	Relationship Strength	Studies	Trials
lactic acid	low	1	0
acetaminophen	low	1	0
ibuprofen	low	1	0
apnea	low	1	0
malondialdehyde	low	1	0
acetylcysteine	low	1	0
transferrin	low	1	0
trenbolone acetate	medium	1	1
estradiol 3-benzoate	medium	1	1
retinol	medium	1	1
sodium bicarbonate	low	1	0
dinoprostone	low	1	0
morphine	low	3	0

Protein Targets (299)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	4	0	0	4
ATAD5 protein, partial	3	0	0	3
GLS protein	2	0	0	2
Microtubule-associated protein tau	4	0	0	4
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
thyroid stimulating hormone receptor	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
progesterone receptor	1	0	0	1
EWS/FLI fusion protein	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	5	0	0	5
retinoid X nuclear receptor alpha	5	0	0	5
estrogen-related nuclear receptor alpha	6	0	0	6
estrogen nuclear receptor alpha	8	0	0	8
peroxisome proliferator activated receptor gamma	3	0	0	3
aryl hydrocarbon receptor	2	0	0	2
chromobox protein homolog 1	3	0	0	3
thyroid hormone receptor beta isoform 2	5	0	0	5
peripheral myelin protein 22	6	0	0	6
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
ATP-binding cassette sub-family C member 3	0	1	0	1
Multidrug resistance-associated protein 4	0	1	0	2
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Bile salt export pump	0	4	0	4
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	0	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	2	2	4
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	3	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	2
Carbonic anhydrase 7	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Cytochrome P450 2J2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Carbonic anhydrase 9	0	2	0	2
GABA theta subunit	2	0	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
toxin B	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
acetylcholinesterase	3	0	0	3
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	2	0	0	2
phosphopantetheinyl transferase	2	0	0	2
USP1 protein, partial	4	0	0	4
NFKB1 protein, partial	2	0	0	2
Thrombopoietin	1	0	0	1
AR protein	7	0	0	7
regulator of G-protein signaling 4	2	0	0	2
glucocorticoid receptor [Homo sapiens]	5	0	0	5
farnesoid X nuclear receptor	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
arylsulfatase A	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
Bloom syndrome protein isoform 1	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
thyroid hormone receptor beta isoform a	1	0	0	1
heat shock protein beta-1	2	0	0	2
flap endonuclease 1	1	0	0	1
geminin	5	0	0	5
survival motor neuron protein isoform d	2	0	0	2
muscarinic acetylcholine receptor M1	1	0	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase 4	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Histone deacetylase 1	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Ataxin-2	1	0	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
ATP-dependent phosphofructokinase	1	0	0	1
thioredoxin reductase	2	0	0	2
TDP1 protein	5	0	0	5
lamin isoform A-delta10	3	0	0	3
neuropeptide S receptor isoform A	1	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, Cruzipain	3	0	0	3
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
GLI family zinc finger 3	2	0	0	2
thyroid stimulating hormone receptor	3	0	0	3
activating transcription factor 6	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Cellular tumor antigen p53	4	0	0	4
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, Beta-lactamase	1	0	0	1
Luciferase	2	0	0	2
glp-1 receptor, partial	2	0	0	2
G	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
huntingtin isoform 2	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
streptokinase A precursor	0	0	1	1
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	0	2
Sex hormone-binding globulin	0	0	1	1
Estrogen receptor	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	0	1
Glycine receptor subunit alpha-1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Adenosine receptor A3	0	2	0	2
Androgen receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Estrogen receptor beta	0	0	1	1
Inositol hexakisphosphate kinase 1	1	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
nonstructural protein 1	1	0	0	1
67.9K protein	1	0	0	1
IDH1	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Albumin	0	1	1	2
Albumin	0	1	0	1
Albumin	0	0	1	1
Cholinesterase	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Caspase-1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Mu-type opioid receptor	0	3	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
TAR DNA-binding protein 43	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
estrogen receptor 2 (ER beta)	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
cytochrome P450 2D6	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	0	1	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	2
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	3	1	7
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	4
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
interleukin 8	1	0	0	1
pregnane X nuclear receptor	1	0	0	1
peroxisome proliferator-activated receptor delta	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Alpha-synuclein	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Polymerase acidic protein	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(6)

Research Excerpts

Actions

Research

Studies (11)

Protein Targets (299)

Double Nuchal Cord

Synonyms(6)

Research Excerpts

Actions

Research

Studies (11)

Drugs Studied (16)

Protein Targets (299)