Page last updated: 2024-08-24

mk 0591 and leukotriene e4

mk 0591 has been researched along with leukotriene e4 in 7 studies

Research

Studies (7)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (85.71)	18.2507
2000's	1 (14.29)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Arruda, JM; Baccei, C; Bain, G; Chapman, C; Correa, L; Darlington, J; Evans, JF; Hutchinson, JH; King, CD; Lee, C; Li, Y; Lorrain, D; Prasit, P; Prodanovich, P; Rong, H; Santini, A; Stock, N	1
Bajwa, K; Becker, AB; Black, C; Ford-Hutchinson, AW; Lilley, MK; Simons, FE; Tagari, P	1
Black, C; Ellis, R; Ford-Hutchinson, A; Lane, CG; O'Byrne, PM; Stevens, WH; Tagari, P; Woolley, MJ	1
Black, C; Brideau, C; Chan, C; Ford-Hutchinson, A; Frenette, R; Tagari, P	1
Becker, A; Brideau, C; Ford-Hutchinson, A; Frenette, R; Sadl, V; Tagari, P; Thomas, E; Vickers, P	1
Friedman, BS; Hara, K; Kanamaru, M; Kosuge, K; Nakashima, M; Takenaga, N; Tanaka, W; Uchiyama, N; Uematsu, T	1
De Lepeleire, I; De Schepper, PJ; Depré, M; Larson, P; Lin, C; Porras, A; Schwartz, J; Van Hecken, A; Verbesselt, R	1

Trials

2 trial(s) available for mk 0591 and leukotriene e4

Article	Year
Pharmacokinetic and pharmacodynamic analysis of a novel leukotriene biosynthesis inhibitor, MK-0591, in healthy volunteers. British journal of clinical pharmacology, 1995, Volume: 40, Issue:1 Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Eating; Fasting; Humans; Indoles; Japan; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Middle Aged; Quinolines	1995
Pharmacokinetic and pharmacodynamic interaction between the lipoxygenase inhibitor MK-0591 and the cyclooxygenase inhibitor ibuprofen in man. International journal of clinical pharmacology research, 1998, Volume: 18, Issue:2 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Digestive System; Double-Blind Method; Drug Interactions; Drug Tolerance; Humans; Ibuprofen; Indoles; Kidney; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Quinolines; Thromboxane B2	1998

Article

Year

Pharmacokinetic and pharmacodynamic analysis of a novel leukotriene biosynthesis inhibitor, MK-0591, in healthy volunteers.

British journal of clinical pharmacology, 1995, Volume: 40, Issue:1

Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Eating; Fasting; Humans; Indoles; Japan; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Middle Aged; Quinolines

1995

Pharmacokinetic and pharmacodynamic interaction between the lipoxygenase inhibitor MK-0591 and the cyclooxygenase inhibitor ibuprofen in man.

International journal of clinical pharmacology research, 1998, Volume: 18, Issue:2

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Digestive System; Double-Blind Method; Drug Interactions; Drug Tolerance; Humans; Ibuprofen; Indoles; Kidney; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Quinolines; Thromboxane B2

1998

Other Studies

5 other study(ies) available for mk 0591 and leukotriene e4

Article	Year
5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19 Topics: 5-Lipoxygenase-Activating Proteins; Animals; Asthma; Carrier Proteins; Dogs; Drug-Related Side Effects and Adverse Reactions; Heterocyclic Compounds; Humans; Indoles; Inhibitory Concentration 50; Leukotriene B4; Membrane Proteins; Mice; Propionates; Protein Binding; Rats; Structure-Activity Relationship	2009
Antiasthmatic effects of a leukotriene biosynthesis inhibitor (MK-0591) in allergic dogs. Journal of applied physiology (Bethesda, Md. : 1985), 1995, Volume: 78, Issue:2 Topics: 5-Lipoxygenase-Activating Proteins; Airway Resistance; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Carrier Proteins; Dogs; Histamine; Indoles; Leukotriene Antagonists; Leukotriene B4; Leukotriene E4; Leukotrienes; Membrane Proteins; Quinolines; Respiratory Hypersensitivity	1995
Effect of FLAP antagonist MK-0591 on leukotriene production and ozone-induced airway responses in dogs. Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 76, Issue:4 Topics: 5-Lipoxygenase-Activating Proteins; Acetylcholine; Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Carrier Proteins; Dogs; Indoles; Inflammation; Leukotriene Antagonists; Leukotriene B4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Ozone; Quinolines; Respiratory System	1994
Assessment of the in vivo biochemical efficacy of orally active leukotriene biosynthesis inhibitors. Agents and actions, 1993, Volume: 40, Issue:1-2 Topics: Animals; Calcimycin; Chromatography, High Pressure Liquid; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Quinolines	1993
Leukotriene generation and metabolism in dogs: inhibition of biosynthesis by MK-0591. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:1 Topics: 5-Lipoxygenase-Activating Proteins; Animals; Asthma; Carrier Proteins; Disease Models, Animal; Dogs; Indoles; Leukotriene Antagonists; Leukotriene E4; Leukotrienes; Membrane Proteins; Quinolines; SRS-A	1993