mk 0591 has been researched along with leukotriene b4 in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (91.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brideau, C; Chan, C; Charleson, S; Denis, D; Evans, JF; Ford-Hutchinson, AW; Fortin, R; Gillard, JW; Guay, J; Guévremont, D | 1 |
| Bukhave, K; Depré, M; Friedman, BS; Hillingsø, J; Kjeldsen, J; Lauritsen, K; Laursen, LS; Malmström, K; Shingo, S; von Spreckelsen, S | 1 |
| Bajwa, K; Becker, AB; Black, C; Ford-Hutchinson, AW; Lilley, MK; Simons, FE; Tagari, P | 1 |
| Dallob, A; de Lepeleire, I; de Schepper, PJ; Depré, M; Friedman, B; Lin, C; Porras, A; Shingo, S; Tanaka, W; Van Hecken, A | 1 |
| Black, C; Ellis, R; Ford-Hutchinson, A; Lane, CG; O'Byrne, PM; Stevens, WH; Tagari, P; Woolley, MJ | 1 |
| Borgeat, P; Marleau, S; Odeimat, A; Palmantier, R; Poubelle, PE; Surette, ME | 1 |
| Friedman, BS; Hara, K; Kanamaru, M; Kosuge, K; Nakashima, M; Takenaga, N; Tanaka, W; Uchiyama, N; Uematsu, T | 1 |
| Berger, ML; Berlin, RG; Cagliola, A; Haggitt, RC; Hanauer, SB; Reagan, JE; Roberts, WG; Simon, S; Simon, TJ; Snyder, ES; Stenson, WF; Tanaka, WK | 1 |
| De Lepeleire, I; De Schepper, PJ; Depré, M; Larson, P; Lin, C; Porras, A; Schwartz, J; Van Hecken, A; Verbesselt, R | 1 |
| Borgeat, P; Fruteau de Laclos, B; Marleau, S; Poubelle, PE; Sanchez, AB | 1 |
| Borgeat, P; Krump, E; Picard, S; Surette, ME | 1 |
| Borgeat, P; Bourgoin, SG; Flamand, N; Grenier, S; Naccache, PH; Pelletier, J | 1 |
5 trial(s) available for mk 0591 and leukotriene b4
| Article | Year |
|---|---|
Blockade of leukotriene production by a single oral dose of MK-0591 in active ulcerative colitis.
Topics: Acute Disease; Administration, Oral; Adult; Colitis, Ulcerative; Dinoprostone; Double-Blind Method; Female; Humans; Indoles; Leukotriene B4; Male; Middle Aged; Quinolines | 1995 |
Pharmacokinetics and pharmacodynamics of multiple oral doses of MK-0591, a 5-lipoxygenase-activating protein inhibitor.
Topics: 5-Lipoxygenase-Activating Proteins; Administration, Oral; Adult; Analysis of Variance; Carrier Proteins; Double-Blind Method; Humans; Indoles; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Quinolines; Reference Values; Respiratory Function Tests; Testosterone | 1994 |
Pharmacokinetic and pharmacodynamic analysis of a novel leukotriene biosynthesis inhibitor, MK-0591, in healthy volunteers.
Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Eating; Fasting; Humans; Indoles; Japan; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Middle Aged; Quinolines | 1995 |
Leukotrienes in ulcerative colitis: results of a multicenter trial of a leukotriene biosynthesis inhibitor, MK-591.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Colitis, Ulcerative; Double-Blind Method; Female; Humans; Indoles; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Quinolines | 1997 |
Pharmacokinetic and pharmacodynamic interaction between the lipoxygenase inhibitor MK-0591 and the cyclooxygenase inhibitor ibuprofen in man.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Digestive System; Double-Blind Method; Drug Interactions; Drug Tolerance; Humans; Ibuprofen; Indoles; Kidney; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Quinolines; Thromboxane B2 | 1998 |
7 other study(ies) available for mk 0591 and leukotriene b4
| Article | Year |
|---|---|
Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor.
Topics: 5-Lipoxygenase-Activating Proteins; Administration, Oral; Animals; Antigens; Arachidonate 5-Lipoxygenase; Ascaris; Bronchoconstriction; Carrier Proteins; Drug Interactions; Humans; Indoles; Leukotriene B4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Quinolines; Rats; Rats, Sprague-Dawley; Saimiri | 1992 |
Antiasthmatic effects of a leukotriene biosynthesis inhibitor (MK-0591) in allergic dogs.
Topics: 5-Lipoxygenase-Activating Proteins; Airway Resistance; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Carrier Proteins; Dogs; Histamine; Indoles; Leukotriene Antagonists; Leukotriene B4; Leukotriene E4; Leukotrienes; Membrane Proteins; Quinolines; Respiratory Hypersensitivity | 1995 |
Effect of FLAP antagonist MK-0591 on leukotriene production and ozone-induced airway responses in dogs.
Topics: 5-Lipoxygenase-Activating Proteins; Acetylcholine; Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Carrier Proteins; Dogs; Indoles; Inflammation; Leukotriene Antagonists; Leukotriene B4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Ozone; Quinolines; Respiratory System | 1994 |
Reverse-phase high-performance liquid chromatography analysis of arachidonic acid metabolites in plasma after stimulation of whole blood ex vivo.
Topics: Aged; Animals; Anticoagulants; Arachidonic Acid; Calcimycin; Chromatography, High Pressure Liquid; Eosinophils; Female; Humans; Indoles; Kinetics; Leukotriene Antagonists; Leukotriene B4; Middle Aged; Quinolines; Rabbits; Spectrophotometry, Ultraviolet; Stimulation, Chemical; Synovial Fluid; Time Factors; Zymosan | 1994 |
Role of 5-lipoxygenase products in the local accumulation of neutrophils in dermal inflammation in the rabbit.
Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Movement; Chemotactic Factors; Chromium Radioisotopes; Complement C5a; Dermatitis; Indoles; Inflammation Mediators; Infusions, Intravenous; Injections, Intravenous; Leukotriene B4; Lipoxygenase Inhibitors; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Quinolines; Rabbits; Skin | 1999 |
Activation of leukotriene synthesis in human neutrophils by exogenous arachidonic acid: inhibition by adenosine A(2a) receptor agonists and crucial role of autocrine activation by leukotriene B(4).
Topics: Adenosine; Adrenergic Agonists; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Autocrine Communication; Benzopyrans; Biological Transport; Biotransformation; Calcium; Carboxylic Acids; Cell Nucleus; Eicosapentaenoic Acid; Epoxide Hydrolases; Humans; In Vitro Techniques; Indoles; Kinetics; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Neutrophil Activation; Neutrophils; Phenethylamines; Purinergic P1 Receptor Agonists; Quinolines; Receptor, Adenosine A2A; Receptors, Leukotriene B4 | 1999 |
Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4 and inhibition by adenosine A2A receptor engagement.
Topics: ADP-Ribosylation Factor 1; Arachidonic Acid; Autocrine Communication; Benzopyrans; beta-Alanine; Biological Transport; Carboxylic Acids; Cell Membrane; Eicosapentaenoic Acid; Enzyme Activation; Epoxide Hydrolases; Humans; Indoles; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Phospholipase D; Protein Transport; Purinergic P1 Receptor Antagonists; Quinolines; Receptor, Adenosine A2A; Receptors, Leukotriene B4; Receptors, Purinergic P1; rhoA GTP-Binding Protein | 2003 |