mk 0591 has been researched along with Disease Models, Animal in 6 studies
*Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Charleson, S; Evans, JF; Falgueyret, JP; Hoogsteen, K; Hutchinson, JH; Jones, TR; Kargman, S; Macdonald, D; McFarlane, CS; Nicholson, DW | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Chu, J; Giannopoulos, PF; Joshi, YB; Kirby, LG; Li, JG; Praticò, D; Sperow, M | 1 |
| Kim, KE; Lee, C; Namgung, R; Park, MS; Sohn, MH | 1 |
| Chu, J; Praticò, D | 1 |
| Becker, A; Brideau, C; Ford-Hutchinson, A; Frenette, R; Sadl, V; Tagari, P; Thomas, E; Vickers, P | 1 |
6 other study(ies) available for mk 0591 and Disease Models, Animal
| Article | Year |
|---|---|
Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Arachidonic Acid; Bronchoconstriction; Calcimycin; Carrier Proteins; Crystallography, X-Ray; Disease Models, Animal; Glutathione Transferase; Haplorhini; Humans; Indoles; Lipoxygenase Inhibitors; Male; Membrane Proteins; Models, Molecular; Rats; Seminal Vesicles; Sheep | 1995 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
5-lipoxygenase activating protein reduction ameliorates cognitive deficit, synaptic dysfunction, and neuropathology in a mouse model of Alzheimer's disease.
Topics: 5-Lipoxygenase-Activating Protein Inhibitors; 5-Lipoxygenase-Activating Proteins; Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Female; Indoles; Male; Maze Learning; Mice; Mice, Knockout; Mice, Transgenic; Quinolines; Synapses; tau Proteins | 2013 |
5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner.
Topics: 5-Lipoxygenase-Activating Protein Inhibitors; 5-Lipoxygenase-Activating Proteins; Animals; Animals, Newborn; Body Weight; Bronchopulmonary Dysplasia; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hyperoxia; Indoles; Infant, Newborn; Injections, Subcutaneous; Mice; Oxygen; Pulmonary Alveoli; Quinolines; Time Factors | 2011 |
Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model.
Topics: 5-Lipoxygenase-Activating Protein Inhibitors; 5-Lipoxygenase-Activating Proteins; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Arachidonate 5-Lipoxygenase; Cells, Cultured; Disease Models, Animal; Female; Humans; Indoles; Mice; Mice, Transgenic; Phenotype; Quinolines; Random Allocation; RNA, Messenger | 2012 |
Leukotriene generation and metabolism in dogs: inhibition of biosynthesis by MK-0591.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Asthma; Carrier Proteins; Disease Models, Animal; Dogs; Indoles; Leukotriene Antagonists; Leukotriene E4; Leukotrienes; Membrane Proteins; Quinolines; SRS-A | 1993 |