Compounds > norrisolide
Page last updated: 2024-11-12

norrisolide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

norrisolide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11349389
CHEMBL ID514367
SCHEMBL ID5513805
MeSH IDM0465998

Synonyms (4)

Synonym
CHEMBL514367
norrisolide
SCHEMBL5513805
[(2r,3r,3ar,6ar)-3-[1-[(1r,3as,7as)-4,4,7a-trimethyl-2,3,3a,5,6,7-hexahydro-1h-inden-1-yl]ethenyl]-5-oxo-3,3a,4,6a-tetrahydro-2h-furo[2,3-b]furan-2-yl] acetate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID462416Golgi-disturbing activity in golgi apparatus of rat NRK cells assessed as golgi fragmentation after 60 mins by Hoechst 3342 staining-based immunofluorescence microscopy in presence of PKD inhibitor H892010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Chemical biology studies on norrisolide.
AID462423Golgi-disturbing activity in golgi apparatus of rat NRK cells assessed as golgi fragmentation measured after 60 mins following drug washout by Hoechst 3342 staining-based immunofluorescence microscopy2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Chemical biology studies on norrisolide.
AID359620Inhibition of bee venom PLA2 assessed as inactivation of enzyme at 2 ug/ml1992Journal of natural products, Dec, Volume: 55, Issue:12
Phospholipase A2 inhibitors from marine organisms.
AID462415Golgi-disturbing activity in golgi apparatus of rat NRK cells assessed as enhancement of nocodazole-induced golgi fragmentation after 60 mins by Hoechst 3342 staining-based immunofluorescence microscopy2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Chemical biology studies on norrisolide.
AID462419Golgi-disturbing activity in golgi apparatus of rat NRK cells assessed as transport of GFP-fused VSV G protein from endoplasmic reticulum to golgi after 60 mins by protein transport assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Chemical biology studies on norrisolide.
AID462420Golgi-disturbing activity in golgi apparatus of rat NRK cells assessed as transport of GFP-fused VSV G protein from fragmented golgi to plasma membrane after 60 mins by protein transport assay2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Chemical biology studies on norrisolide.
AID462414Golgi-disturbing activity in golgi apparatus of rat NRK cells assessed as microtubule depolymerization-associated golgi fragmentation after 60 mins by Hoechst 3342 staining-based immunofluorescence microscopy in presence of Taxol2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Chemical biology studies on norrisolide.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's6 (75.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.94 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index5.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.94)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
iodine
Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..		2.0310diatomic iodinenutrient
nocodazole
[no description available]		2.0510aromatic ketone;
benzimidazoles;
carbamate ester;
thiophenes		antimitotic;
antineoplastic agent;
microtubule-destabilising agent;
tubulin modulator
illimaquinone
illimaquinone: structure given in first source; isolated from the Red Sea sponge Smenospongia; inhibits the RNase H. activity of HIV-1 reverse transcriptase		3.5120monohydroxy-1,4-benzoquinones;
prenylquinone		metabolite
biotin
vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.		2.0310biotins;
vitamin B7		coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
brefeldin a
[no description available]		2.0510macrolide antibioticPenicillium metabolite
luffariellolide
luffariellolide: structure given in first source; a partially reversible phospholipase A2 inhibitor; a major metabolite of the sponge Luffariella; do not confuse with luffolide, a minor metabolite of the same species		3.0810diterpene lactone
manoalide
manoalide: phospholipase A2 inhibitor; sesterterpene from marine sponge L. variabilis; structure given in first source. manoalide : A sesterterpenoid isolated from the marine sponge Luffariella variabilis and which has been shown to exhibit inhibitory activity towards phospholipase A2.		3.0810butenolide;
lactol;
sesterterpenoid		EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
metabolite
scalaradial
scalaradial: RN refers to the (5alpha,12alpha,17abeta)-isomer; a marine natural product isolated from the sponge Cacospongia sp.; structure given in first source. scalaradial : A scalarane sesterterpenoid with formula C27H40O4. It is a natural product found in the marine sponges Spongia officinalis and Cacospongia mollior, and exhibits anti-inflammatory activity.		3.0810acetate ester;
carbotetracyclic compound;
dialdehyde;
enal;
scalarane sesterterpenoid		animal metabolite;
anti-inflammatory agent;
apoptosis inducer;
EC 3.1.1.4 (phospholipase A2) inhibitor;
marine metabolite;
TRP channel blocker
ConditionIndicatedRelationship StrengthStudiesTrials