Page last updated: 2024-11-13
dictyoceratin-c
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
dictyoceratin-C: from the marine species Spongia sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 21589795 |
| CHEMBL ID | 484222 |
| SCHEMBL ID | 20969115 |
| MeSH ID | M0477097 |
Synonyms (5)
| Synonym |
|---|
| CHEMBL484222 |
| dictyoceratin-c |
| dictyoceratin c |
| SCHEMBL20969115 |
| methyl 3-[[(1r,2s,4as,8as)-1,2,4a-trimethyl-5-methylidene-3,4,6,7,8,8a-hexahydro-2h-naphthalen-1-yl]methyl]-4-hydroxybenzoate |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (12)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1178614 | Inhibition of hypoxia-induced accumulation of HIF-1alpha in human DU145 cells at 10 to 30 uM after 24 hrs by Western blotting analysis | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells. |
| AID1178610 | Antiproliferative activity against human DU145 cells assessed as maximal growth inhibition under hypoxic condition at 10 uM after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells. |
| AID333394 | Cytotoxicity against human A2780 cells | 2004 | Journal of natural products, Oct, Volume: 67, Issue:10 | Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta. |
| AID1439822 | Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess assay | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity. |
| AID333392 | Inhibition of DNA polymerase beta lyase activity | 2004 | Journal of natural products, Oct, Volume: 67, Issue:10 | Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta. |
| AID1178611 | Antiproliferative activity against human DU145 cells assessed as growth inhibition under hypoxic condition at 30 uM after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells. |
| AID1191808 | Antiproliferative activity against human DU145 cells assessed as growth inhibition treated after 12 hrs hypoxic condition and incubated additional 24 hrs under hypoxic condition by MTT assay | 2015 | Bioorganic & medicinal chemistry, Mar-01, Volume: 23, Issue:5 | Enantioselective synthesis of dictyoceratin-A (smenospondiol) and -C, hypoxia-selective growth inhibitors from marine sponge. |
| AID1439823 | Cytotoxicity against mouse BV2 cells assessed as cell viability at 40 uM relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity. |
| AID1178609 | Antiproliferative activity against human DU145 cells assessed as growth inhibition under hypoxic condition after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells. |
| AID1178612 | Antiproliferative activity against human DU145 cells assessed as growth inhibition under normoxic condition at 30 uM after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells. |
| AID1178615 | Inhibition of hypoxia-induced of VEGF production in human DU145 cells at 10 to 30 uM after 24 hrs by Western blotting analysis | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells. |
| AID333393 | Inhibition of GST-fused human recombinant Cdc25B2 (275-539) catalytic domain | 2004 | Journal of natural products, Oct, Volume: 67, Issue:10 | Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 13.25
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.25) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (14.29%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (85.71%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||