Compounds > dictyoceratin-c
Page last updated: 2024-11-13

dictyoceratin-c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

dictyoceratin-C: from the marine species Spongia sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID21589795
CHEMBL ID484222
SCHEMBL ID20969115
MeSH IDM0477097

Synonyms (5)

Synonym
CHEMBL484222
dictyoceratin-c
dictyoceratin c
SCHEMBL20969115
methyl 3-[[(1r,2s,4as,8as)-1,2,4a-trimethyl-5-methylidene-3,4,6,7,8,8a-hexahydro-2h-naphthalen-1-yl]methyl]-4-hydroxybenzoate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1178614Inhibition of hypoxia-induced accumulation of HIF-1alpha in human DU145 cells at 10 to 30 uM after 24 hrs by Western blotting analysis2014Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14
Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells.
AID1178610Antiproliferative activity against human DU145 cells assessed as maximal growth inhibition under hypoxic condition at 10 uM after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14
Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells.
AID333394Cytotoxicity against human A2780 cells2004Journal of natural products, Oct, Volume: 67, Issue:10
Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.
AID1439822Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess assay2017Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7
Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity.
AID333392Inhibition of DNA polymerase beta lyase activity2004Journal of natural products, Oct, Volume: 67, Issue:10
Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.
AID1178611Antiproliferative activity against human DU145 cells assessed as growth inhibition under hypoxic condition at 30 uM after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14
Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells.
AID1191808Antiproliferative activity against human DU145 cells assessed as growth inhibition treated after 12 hrs hypoxic condition and incubated additional 24 hrs under hypoxic condition by MTT assay2015Bioorganic & medicinal chemistry, Mar-01, Volume: 23, Issue:5
Enantioselective synthesis of dictyoceratin-A (smenospondiol) and -C, hypoxia-selective growth inhibitors from marine sponge.
AID1439823Cytotoxicity against mouse BV2 cells assessed as cell viability at 40 uM relative to control2017Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7
Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity.
AID1178609Antiproliferative activity against human DU145 cells assessed as growth inhibition under hypoxic condition after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14
Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells.
AID1178612Antiproliferative activity against human DU145 cells assessed as growth inhibition under normoxic condition at 30 uM after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14
Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells.
AID1178615Inhibition of hypoxia-induced of VEGF production in human DU145 cells at 10 to 30 uM after 24 hrs by Western blotting analysis2014Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14
Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells.
AID333393Inhibition of GST-fused human recombinant Cdc25B2 (275-539) catalytic domain2004Journal of natural products, Oct, Volume: 67, Issue:10
Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's6 (85.71)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.25 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index5.33 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
deoxyuridine
[no description available]		2.0210pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
illimaquinone
illimaquinone: structure given in first source; isolated from the Red Sea sponge Smenospongia; inhibits the RNase H. activity of HIV-1 reverse transcriptase		2.7630monohydroxy-1,4-benzoquinones;
prenylquinone		metabolite
omega-n-methylarginine
omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.		2.1510amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
sesquiterpenes
[no description available]		4.4460
smenospongine
smenospongine: a spongean (Dactylospongia elegans) sesquiterpene aminoquinone, induces erythroid differentiation in K562 cells; structure in first source		2.110
laulimalide
laulimalide: isolated from Cacospongia mycofijiensis; structure in first source. laulimalide : A macrolide with formula C30H42O7 that is isolated from the marine sponges, Cacospongia mycofijiensis and Hyattella sp.		3.2310carboxylic ester;
epoxide;
macrolide;
secondary alcohol;
secondary allylic alcohol		animal metabolite;
antimitotic;
antineoplastic agent;
marine metabolite;
microtubule-stabilising agent
bolinaquinone
bolinaquinone: a marine sesquiterpenoid from sponge Dysidea sp. with anti-inflammatory activity; structure in first source		2.110
ConditionIndicatedRelationship StrengthStudiesTrials
Anoxemia
[description not available]		02.110
Benign Neoplasms
[description not available]		02.5420
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms.		07.110
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.5420
Cancer of Prostate
[description not available]		02.1110
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.1110
Sarcoma 180
An experimental sarcoma of mice.		02.1110