Compounds > endolysin
Page last updated: 2024-09-19

endolysin

Description

lysine-4,4,5,5-d4 : A deuterated compound that is lysne in which the methylene hydrogens at positions 4, 4, 5 and 5 have been replaced by deuterium. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID866
CHEMBL ID28328
CHEBI ID25094
CHEBI ID132486
MeSH IDM0041233

Synonyms (71)

Synonym
lysine, dl-
EN300-34227
AKOS005441647
nsc-620353
dl-lysine
70-54-2
CHEBI:25094 ,
alpha,epsilon-diaminocaproic acid
nsc620353
2,6-diaminohexanoic acid
NCGC00166296-01
NCGC00164527-01
STK387123
(4,4,5,5-(2)h4)lysine
lysine-4,4,5,5-d4
CHEBI:132486
4D4E4503-F6A2-417D-A303-BDCAF08D1EBE
CHEMBL28328
L001250
FT-0693447
FT-0695058
2,6-bis(azanyl)hexanoic acid
A836916
NCGC00164527-02
BBL002414
2,6-diamino-hexanoic acid
h-dl-lys-oh
(+-)-lysine
ai4rt59273 ,
ec 200-740-6
einecs 200-740-6
ccris 8600
(rs)-lysine
unii-ai4rt59273
dl-alpha,epsilon-diaminocaproic acid
(+-)-2,6-diaminohexanoic acid
FT-0625483
FT-0625535
FT-0627942
AM20100662
dl-.alpha.,.epsilon.-diaminocaproic acid
(+/-)-lysine
(+/-)-2,6-diaminohexanoic acid
l-lysine base
Q-201026
CS-7806
mfcd00064433
F8880-9052
mfcd00064432
sr-01000944856
SR-01000944856-1
dl-lysine base
dl-lysine, 98%
dl-lysine, purum, >=95.0% (nt)
endolysin
SY006101
Z57127389
HY-B2236
FT-0772133
Q178430
tetrodotoxincitrate
DTXSID90859004 ,
SB23228
( inverted exclamation marka)-2,6-diaminocaproic acid
lys106
AS-56068
SY006447
SY279831
(+/-)-2,6-diaminocaproic acid
dtxcid00196790
l-lysine-2-15n dihydrochloride

Research Excerpts

Overview

ExcerptReference
"Endolysin is a phage-encoded cell-wall hydrolase which degrades the peptidoglycan layer of the bacterial cell wall. "( Chanarat, S; Chankhamhaengdecha, S; Fagan, RP; Janvilisri, T; Nuadthaisong, J; Phetruen, T; Phothichaisri, W, 2022)
"Endolysins are a novel class of antibacterials with proven efficacy in combating various bacterial infections, in vitro and in vivo. "( Chhibber, S; Harjai, K; Kaur, J; Kour, A; Panda, JJ, 2020)
"Endolysins prove to be a promising class of antibacterials due to their specificity and less chances of resistance development in bacterial pathogens."( Basit, A; Qadir, S; Qureshi, S; Rehman, SU, 2021)
"Endolysin is a promising antibiotic agent against gram-positive bacteria pathogen, such as Streptococcus pneumoniae, Streptococcus pyogenes and Staphylococcus aureus."( Lu, C; Wang, Y, 2009)

Effects

ExcerptReference
"This endolysin has a modular structure with an enzymatically active domain and a cell wall binding domain."( Briers, Y; Gerstmans, H; Lavigne, R; Mesnage, S; Rodríguez-Rubio, L; Thorpe, S, 2016)
"The endolysin has a lysozyme-like superfamily domain, and its activity was much stronger than that of lysozyme from chicken egg white."( Kang, DH; Lim, JA; Ryu, S; Shin, H, 2012)
"Endolysins have been proposed as a potential antibacterial alternative for aquaculture, especially against Vibrio; the bacterial-agents that most frequently cause disease. "( Barraza, A; Cardona-Félix, CS; Loera-Muro, A; Melo-López, FN; Zermeño-Cervantes, LA, 2021)
"Endolysins have been studied against a number of drug-resistant pathogens to assess their therapeutic ability."( Chhibber, S; Gondil, VS; Harjai, K, 2020)
"Endolysins have been proven to have efficient bactericidal activity against pathogens with low incidence of resistance."( Jiang, Y; Li, F; Qu, M; Tan, Z; Wang, L; Xu, D; Yao, L, 2021)
"This endolysin has a modular structure with an enzymatically active domain and a cell wall binding domain."( Briers, Y; Gerstmans, H; Lavigne, R; Mesnage, S; Rodríguez-Rubio, L; Thorpe, S, 2016)
"The endolysin has a lysozyme-like superfamily domain, and its activity was much stronger than that of lysozyme from chicken egg white."( Kang, DH; Lim, JA; Ryu, S; Shin, H, 2012)
"Endolysin engineering has opened a range of new applications for these proteins from food safety to environmental decontamination to more effective antimicrobials that are believed refractory to resistance development."( Dong, S; Donovan, DM; Klumpp, J; Nelson, DC; Pritchard, DG; Rodriguez-Rubio, L; Schmelcher, M, 2012)

Treatment

ExcerptReference
"So endolysin treatment may be a new approach for preventing and controlling of bacteria pathogen."( Lu, C; Wang, Y, 2009)

Roles (1)

RoleDescription
Daphnia magna metaboliteA Daphnia metabolite produced by the species Daphnia magna.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
alpha-amino acidAn amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group.
diamino acidAny amino acid carrying two amino groups.
polar amino acidAny amino acid whose side chain is capable of forming one or more hydrogen bonds.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (4)

endolysin is involved in 4 pathway(s), involving a total of 25 unique proteins and 92 unique compounds

PathwayProteinsCompounds
22q11.2 copy number variation syndrome228
Biotin metabolism, including IMDs912
Amino acid transport defects (IEMs)925
Cerebral organic acidurias, including diseases527

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.14130.003245.467312,589.2998AID2517
lamin isoform A-delta10Homo sapiens (human)Potency28.18380.891312.067628.1838AID1487
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (468)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (2.14)18.7374
1990's14 (2.99)18.2507
2000's59 (12.61)29.6817
2010's250 (53.42)24.3611
2020's135 (28.85)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (0.63%)5.53%
Reviews46 (9.73%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other424 (89.64%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
lipoteichoic acid[no description available]medium10
glycidyl nitrate[no description available]medium690
chitosan[no description available]medium40
n-acetylmuramic acid[no description available]medium20N-acetylmuramic acid
glutamic acid[no description available]medium10glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
silicon phthalocyanine pc4[no description available]medium10
muramidase[no description available]medium150
ro13-9904[no description available]medium10
vancomycin[no description available]medium60glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
ceca1 protein, drosophila[no description available]medium10
edetic acid[no description available]medium70ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
leucine[no description available]medium10amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
lactose[no description available]medium30lactose
trehalose[no description available]medium10trehaloseEscherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
mupirocin[no description available]medium20alpha,beta-unsaturated carboxylic ester;
epoxide;
monocarboxylic acid;
oxanes;
secondary alcohol;
triol		antibacterial drug;
bacterial metabolite;
protein synthesis inhibitor
fusidic acid[no description available]medium1011alpha-hydroxy steroid;
3alpha-hydroxy steroid;
alpha,beta-unsaturated monocarboxylic acid;
steroid acid;
steroid antibiotic;
sterol ester		EC 2.7.1.33 (pantothenate kinase) inhibitor;
Escherichia coli metabolite;
protein synthesis inhibitor
choline[no description available]medium20cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
colistin[no description available]medium20
rhamnose[no description available]medium10L-rhamnose
chlorine[no description available]medium10diatomic chlorine;
gas molecular entity		bleaching agent
hypochlorous acid[no description available]medium10chlorine oxoacid;
reactive oxygen species		EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
human metabolite
gold[no description available]medium20copper group element atom;
elemental gold
rifampin[no description available]medium20cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
daptomycin[no description available]medium20
triamcinolone acetonide[no description available]medium1111beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
cyclic ketal;
fluorinated steroid;
glucocorticoid;
primary alpha-hydroxy ketone		anti-allergic agent;
anti-inflammatory drug
adenosine monophosphate[no description available]medium10adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
arabinogalactan[no description available]medium20
propane[no description available]medium10alkane;
gas molecular entity		food propellant
glyceraldehyde[no description available]medium10aldotriosefundamental metabolite
butyric acid[no description available]medium10fatty acid 4:0;
straight-chain saturated fatty acid		human urinary metabolite;
Mycoplasma genitalium metabolite
reuterin[no description available]medium10alpha-CH2-containing aldehyde;
propanals
5-amino-2,4,6-triiodoisophthalic acid[no description available]medium10
acebutolol[no description available]medium10alpha-D-glucosyl-(1->4)-D-mannopyranose
pyrethrins[no description available]medium10
bifenthrin[no description available]medium10carboxylic ester;
cyclopropanecarboxylate ester;
cyclopropanes;
organochlorine compound;
organofluorine compound		pyrethroid ester acaricide;
pyrethroid ester insecticide
aspartic acid[no description available]medium10aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
asparagine[no description available]medium10amino acid zwitterion;
asparagine;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
oligonucleotides[no description available]medium10
alanine[no description available]medium10alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
acetylglucosamine[no description available]medium20N-acetyl-D-glucosamineepitope
cysteine[no description available]medium20cysteiniumfundamental metabolite
histidine[no description available]medium40amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
ciprofloxacin[no description available]medium10aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
malic acid[no description available]medium102-hydroxydicarboxylic acid;
C4-dicarboxylic acid		food acidity regulator;
fundamental metabolite
citric acid, anhydrous[no description available]medium10tricarboxylic acidantimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite
minocycline[no description available]medium20
penicillin g[no description available]medium10penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope
ceftobiprole[no description available]medium10cephalosporin;
thiadiazoles		antimicrobial agent
cephalosporin c[no description available]medium10cephalosporinfungal metabolite
2-heptyl-3-hydroxy-4-quinolone[no description available]medium10quinolonesignalling molecule
carbostyril[no description available]medium10monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
urea[no description available]medium30isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
dodecylphosphocholine[no description available]medium10phosphocholinesdetergent
phosphorylcholine[no description available]medium10phosphocholinesallergen;
epitope;
hapten;
human metabolite;
mouse metabolite
chlorhexidine[no description available]medium10biguanides;
monochlorobenzenes		antibacterial agent;
antiinfective agent
carvacrol[no description available]medium10botanical anti-fungal agent;
p-menthane monoterpenoid;
phenols		agrochemical;
antimicrobial agent;
flavouring agent;
TRPA1 channel agonist;
volatile oil component
1,2-bis(2-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid[no description available]medium10polyamino carboxylic acid;
tetracarboxylic acid		chelator
egtazic acid[no description available]medium10diether;
tertiary amino compound;
tetracarboxylic acid		chelator
chlorine[no description available]medium10halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
3-toluic acid[no description available]medium10methylbenzoic acidhuman xenobiotic metabolite
glycerol[no description available]medium10alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
mitomycin[no description available]medium20mitomycinalkylating agent;
antineoplastic agent
chloramphenicol[no description available]medium10C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
cyanides[no description available]medium10pseudohalide anionEC 1.9.3.1 (cytochrome c oxidase) inhibitor
tetraphenylphosphonium[no description available]medium10heteroorganic entity;
phosphorus molecular entity;
polyatomic cation
4-nitrophenyl butyrate[no description available]medium10butyrate ester;
C-nitro compound
1-anilino-8-naphthalenesulfonate[no description available]medium10aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
acetic acid[no description available]low00monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
adenine[no description available]low006-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cadaverine[no description available]low00alkane-alpha,omega-diamineDaphnia magna metabolite;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite
lactic acid[no description available]low002-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
dimethylglycine[no description available]low00amino acid zwitterion;
N-methyl-amino acid;
N-methylglycines		Daphnia magna metabolite;
human metabolite;
mouse metabolite
glutaric acid[no description available]low00alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid		Daphnia magna metabolite;
human metabolite
racemethionine[no description available]medium00alpha-amino acid;
amino acid zwitterion;
sulfur-containing amino acid		algal metabolite;
Daphnia magna metabolite;
Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
palmitic acid[no description available]low00long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite
phenylalanine[no description available]medium00alpha-amino acid;
aromatic amino acid		Daphnia magna metabolite
tryptophan[no description available]medium00alpha-amino acid;
amino acid zwitterion;
aminoalkylindole;
aromatic amino acid;
polar amino acid		Daphnia magna metabolite
uracil[no description available]low00pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
p-aminohippuric acid[no description available]low00N-acylglycineDaphnia magna metabolite
stearic acid[no description available]low00long-chain fatty acid;
saturated fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
human metabolite;
plant metabolite
androstenedione[no description available]low0017-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
isobutyric acid[no description available]low00branched-chain saturated fatty acid;
fatty acid 4:0;
methyl-branched fatty acid		Daphnia magna metabolite;
plant metabolite;
volatile oil component
pelargonic acid[no description available]low00medium-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
antifeedant;
Daphnia magna metabolite;
plant metabolite
pyrimidine[no description available]low00diazine;
pyrimidines		Daphnia magna metabolite
pyrazines[no description available]low00diazine;
pyrazines		Daphnia magna metabolite
citrulline[no description available]low00amino acid zwitterion;
citrulline		Daphnia magna metabolite;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
protective agent;
Saccharomyces cerevisiae metabolite
margaric acid[no description available]low00long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
mammalian metabolite
dihydrotestosterone[no description available]low0017beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
myristic acid[no description available]low00long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite
pentadecanoic acid[no description available]low00long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
food component;
human blood serum metabolite;
plant metabolite
5 alpha-androstane-3 alpha,17 beta-diol[no description available]low00androstane-3alpha,17beta-diolDaphnia magna metabolite;
human metabolite
tricosanoic acid[no description available]low00straight-chain saturated fatty acid;
very long-chain fatty acid		Daphnia magna metabolite;
human metabolite;
plant metabolite
aminomalonic acid[no description available]low00amino dicarboxylic acidDaphnia magna metabolite;
human metabolite
5 alpha-androstane-3 beta,17 beta-diol[no description available]low0017beta-hydroxy steroid;
3beta-hydroxy steroid;
androstane-3,17-diol		Daphnia magna metabolite;
human metabolite
15-hydroxytestosterone[no description available]low0015alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
Daphnia magna metabolite
carnosine[no description available]low00amino acid zwitterion;
dipeptide		anticonvulsant;
antineoplastic agent;
antioxidant;
Daphnia magna metabolite;
geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent
turanose[no description available]low00glycosylfructoseDaphnia magna metabolite
DL-Canavanine[no description available]low00alpha-amino acid
n(g),n(g')-dimethyl-l-arginine[no description available]low00alpha-amino acid
cysteine[no description available]low00alpha-amino acid;
amino acid zwitterion;
polar amino acid;
sulfur-containing amino acid		fundamental metabolite
alanine[no description available]low00alpha-amino acid;
amino acid zwitterion		fundamental metabolite
glycine[no description available]low00alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
(alpha-carboxycyclopropyl)glycine[no description available]low00alpha-amino acid
1-aminocyclohexanecarboxylic acid[no description available]low00alpha-amino acid
2-amino-3-(5-tert-butyl-3-oxo-4-isoxazolyl)propanoic acid[no description available]low00alpha-amino acid
alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate[no description available]low00alpha-amino acid
eflornithine[no description available]low00alpha-amino acid;
fluoroamino acid		trypanocidal drug
mimosine[no description available]low00alpha-amino acid
4-carboxyphenylglycine[no description available]low00alpha-amino acid
acediasulfone[no description available]low00alpha-amino acid
methiin[no description available]low00alpha-amino acid
2-amino-5-hydroxyvaleric acid[no description available]low00alpha-amino acid
1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid[no description available]low00alpha-amino acid;
aromatic amino acid;
beta-carboline alkaloid		human urinary metabolite;
human xenobiotic metabolite;
plant metabolite;
rat metabolite
3,5-dihydroxyphenylglycine[no description available]low00alpha-amino acid
alliin[no description available]low00alpha-amino acid
laminine[no description available]low00alpha-amino acid
homocysteinesulfinic acid[no description available]low00alpha-amino acid
spinacine[no description available]low00alpha-amino acid
edba[no description available]low00alpha-amino acid
tissue plasminogen activator[no description available]low00alpha-amino acid
ubp296[no description available]low00alpha-amino acid
cycloalliin[no description available]low00alpha-amino acid
furosine[no description available]low00alpha-amino acid
4-hydroxy-4-(indol-3-ylmethyl)glutamic acid[no description available]low00alpha-amino acid
2,3-diaminopropionic acid[no description available]low00alanine derivative;
amino acid zwitterion;
beta-amino acid;
diamino acid;
non-proteinogenic alpha-amino acid		Escherichia coli metabolite
2,4-diaminobutyric acid[no description available]low00diamino acid;
gamma-amino acid;
non-proteinogenic alpha-amino acid
beta-n-methylamino-l-alanine[no description available]low00diamino acid;
L-alanine derivative;
non-proteinogenic L-alpha-amino acid;
secondary amino compound		bacterial metabolite;
neurotoxin
ConditionIndicatedRelationship StrengthStudiesTrials
Acinetobacter Infections0low20
Acne0low10
Acne Vulgaris0low10
Adverse Drug Event0low10
Adverse Drug Reaction0low10
Angiitis0low10
Anthrax0low10
Antibiotic-Associated Colitis0low10
Bacillus anthracis Infection0low10
Bacteremia0low30
Bacterial Disease0low140
Bacterial Infection0low140
Bacterial Infections0low140
Bacterial Infections, Gram-Negative0low20
Bacterial Infections, Gram-Positive0low80
Bacterial Vaginitides0low10
Bacterial Vaginitis0low10
Bacterial Vaginoses0low10
Bacterial Vaginosis0low10
Blood Poisoning0low10
Bloodstream Infection0low10
Bovine Diseases0low20
Burns0low20
Buruli Ulcer0low10
Buruli Ulcer Disease0low10
Cancer of Skin0low10
Cancer of the Skin0low10
Cattle Diseases0low20
Cellulitis0low10
Chromosome Deletion0low10
Clostridioides difficile Infection0low10
Clostridioides Infections0low10
Clostridioides perfringens Food Poisoning0low10
Clostridioides perfringens Infections0low10
Clostridioides sordellii Infection0low10
Clostridium difficile Infection0low10
Clostridium difficile Infections0low10
Clostridium Enterocolitis0low10
Clostridium Infections0low10
Clostridium perfringens Food Poisoning0low10
Clostridium perfringens Infections0low10
Clostridium sordellii Infection0low10
Clostridium sordellii Infections0low10
Colitis, Pseudomembranous0low10
Communicable Diseases0low10
Complications, Infectious Pregnancy0low10
Cross Infection0low10
Cutaneous T-Cell Lymphoma0low10
Cystic Fibrosis0low10
Cystic Fibrosis of Pancreas0low10
Cytomegalovirus0low10
Dermatitis, Atopic0medium32
Disbacteriosis0low10
Disbiosis0low10
Disease Models, Animal0low110
Drug Side Effects0low10
Drug Toxicity0low10
Drug-Related Side Effects and Adverse Reactions0low10
Dys-symbiosis0low10
Dysbacteriosis0low10
Dysbiosis0low10
E coli Infections0low10
E. coli Infection0low10
Eczema, Atopic0medium32
Eczema, Infantile0medium32
Endophthalmitis0low10
Enteritis, Pseudomembranous0low10
Enterocolitis, Pseudomembranous0low10
Escherichia coli Infections0low10
Experimental Lung Inflammation0low10
Experimental Pneumococcal Meningitis0low10
Extravascular Hemolysis0low10
Fibrocystic Disease of Pancreas0low10
Fish Diseases0low10
Food Poisoning0low20
Food-borne Disease0low20
Food-borne Diseases0low20
Food-borne Illness0low20
Food-borne Illnesses0low20
Foodborne Disease0low20
Foodborne Diseases0low20
Foodborne Illness0low20
Foodborne Illnesses0low20
Gas Gangrene0low10
Gram-Negative Bacterial Infections0low20
Gram-Positive Bacterial Infections0low80
Granulomatous Slack Skin0low10
Group A Strep Infection0low80
Group A Streptococcal Infection0low80
Group A Streptococcal Infections0low80
Group B Strep Infection0low80
Group B Streptococcal Infection0low80
Group B Streptococcal Infections0low80
Haemolysis0low10
Health Care Associated Infection0low10
Health Care Associated Infections0low10
Healthcare Associated Infections0low10
Hemolysis0low10
Hospital Infections0low10
Impetigo0low10
Impetigo Contagiosa0low10
Infection, Bacterial0low140
Infection, Cross0low10
Infection, Wound0low10
Infections, Acinetobacter0low20
Infections, Bacterial0low140
Infections, Clostridium0low10
Infections, E coli0low10
Infections, Escherichia coli0low10
Infections, Gram-Negative Bacterial0low20
Infections, Gram-Positive Bacterial0low80
Infections, Hospital0low10
Infections, Klebsiella0low10
Infections, Mimae0low20
Infections, Mycobacterium ulcerans0low10
Infections, Nosocomial0low10
Infections, Prosthesis-Related0low10
Infections, Salmonella0low10
Infections, Staphylococcal0medium362
Infections, Staphylococcal Skin0medium11
Infections, Streptococcal0low80
Infectious Diseases0low10
Infectious Endophthalmitis0low10
Infectious Pregnancy Complications0low10
Infectious Skin Diseases0low20
Intravascular Hemolysis0low10
Klebsiella Infections0low10
Lobar Pneumonia0low10
Lung Inflammation0low10
Lymphoma, T Cell, Cutaneous0low10
Lymphoma, T-Cell, Cutaneous0low10
Mastitis0low30
Mastitis, Bovine0low70
Maternal Sepsis0low10
Meningitis, Pneumococcal0low10
Meningitis, Pneumococcal, Experimental0low10
Meningitis, Pneumococcal, Penicillin-Resistant0low10
Meningitis, Pneumococcal, Recurrent0low10
Meningitis, Streptococcus pneumoniae0low10
Middle Ear Inflammation0low20
Mimae Infections0low20
Monosomy, Partial0low10
Mucoviscidosis0low10
Mycobacterium ulcerans Infection0low10
Neoplasms, Skin0low10
Neurodermatitis, Atopic0medium32
Neurodermatitis, Disseminated0medium32
Nosocomial Infections0low10
Ophthalmia0low10
Opportunistic Infections0low10
Otitis Media0low20
Pancreatic Cystic Fibrosis0low10
Partial Monosomy0low10
Phlegmon0low10
Pneumonia0low10
Pneumonia, Lobar0low10
Pneumonia, Pneumococcal0low20
Pneumonitis0low10
Poisoning, Blood0low10
Poisoning, Food0low20
Poultry Diseases0low10
Pregnancy0low20
Pregnancy Complications, Infectious0low10
Pregnancy, Infectious Complications0low10
Premature Birth0low10
Preterm Birth0low10
Prosthesis Related Infection0low10
Prosthesis-Related Infection0low10
Prosthesis-Related Infections0low10
Pseudomembranous Colitis0low10
Pseudomembranous Enteritis0low10
Pseudomembranous Enterocolitis0low10
Pulmonary Cystic Fibrosis0low10
Pulmonary Inflammation0low10
Pyaemia0low10
Pyemia0low10
Pyohemia0low10
Salmonella Infections0low10
Salmonellosis0low10
Sepsis0low10
Sepsis during Pregnancy0low10
Sepsis in Pregnancy0low10
Septicemia0low10
Severe Sepsis0low10
Side Effects of Drugs0low10
Skin Cancer0low10
Skin Diseases, Infectious0low20
Skin Diseases, Staphylococcal0medium11
Skin Infections, Staphylococcal0medium11
Skin Neoplasms0low10
Staphylococcal Diseases, Skin0medium11
Staphylococcal Infections0medium362
Staphylococcal Infections, Skin0medium11
Staphylococcal Skin Diseases0medium11
Staphylococcal Skin Infections0medium11
Staphylococcus aureus Infection0medium362
Streptococcal Infections0low80
T-Cell Lymphoma, Cutaneous0low10
Toxicity, Drug0low10
Vaginitides, Bacterial0low10
Vaginitis, Bacterial0low10
Vaginitis, Nonspecific0low10
Vaginoses, Bacterial0low10
Vaginosis, Bacterial0low10
Vasculitis0low10
Wound Infection0low10

Research Highlights

Safety/Toxicity (4)

ArticleYear
Phage Endolysins: Advances in the World of Food Safety.
Cells, 08-29, Volume: 12, Issue: 17		2023
Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal.
Viruses, 11-15, Volume: 10, Issue: 11		2018
Bacteriophage endolysins: applications for food safety.
Current opinion in biotechnology, Volume: 37		2016
Preclinical safety evaluation of intravenously administered SAL200 containing the recombinant phage endolysin SAL-1 as a pharmaceutical ingredient.
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 4		2014
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (3)

ArticleYear
Pharmacokinetics and Tolerance of the Phage Endolysin-Based Candidate Drug SAL200 after a Single Intravenous Administration among Healthy Volunteers.
Antimicrobial agents and chemotherapy, Volume: 61, Issue: 6		2017
Pharmacokinetics of the phage endolysin-based candidate drug SAL200 in monkeys and its appropriate intravenous dosing period.
Clinical and experimental pharmacology & physiology, Volume: 43, Issue: 10		2016
A stable phage lysin (Cpl-1) dimer with increased antipneumococcal activity and decreased plasma clearance.
International journal of antimicrobial agents, Volume: 38, Issue: 6		2011
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (2)

ArticleYear
Advanced engineering of third-generation lysins and formulation strategies for clinical applications.
Critical reviews in microbiology, Volume: 46, Issue: 5		2020
Comprehensive evaluation of chitosan nanoparticle based phage lysin delivery system; a novel approach to counter S. pneumoniae infections.
International journal of pharmaceutics, Jan-05, Volume: 573		2020
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (4)

ArticleYear
Determination of Bactericidal Activity Spectrum of Recombinant Endolysins of ECD7, Am24, Ap22, Si3, and St11 Bacteriophages.
Bulletin of experimental biology and medicine, Volume: 170, Issue: 5		2021
Recent advances in therapeutic delivery systems of bacteriophage and bacteriophage-encoded endolysins.
Therapeutic delivery, Volume: 8, Issue: 7		2017
Pharmacokinetics and Tolerance of the Phage Endolysin-Based Candidate Drug SAL200 after a Single Intravenous Administration among Healthy Volunteers.
Antimicrobial agents and chemotherapy, Volume: 61, Issue: 6		2017
Pharmacokinetics of the phage endolysin-based candidate drug SAL200 in monkeys and its appropriate intravenous dosing period.
Clinical and experimental pharmacology & physiology, Volume: 43, Issue: 10		2016
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (4)

ArticleYear
Characterization of Salmonella endolysin XFII produced by recombinant Escherichia coli and its application combined with chitosan in lysing Gram-negative bacteria.
Microbial cell factories, Aug-23, Volume: 21, Issue: 1		2022
Endolysin LysSTG2: Characterization and application to control Salmonella Typhimurium biofilm alone and in combination with slightly acidic hypochlorous water.
Food microbiology, Volume: 98		2021
Efficacy of nisin derivatives with improved biochemical characteristics, alone and in combination with endolysin PlyP100 to control Listeria monocytogenes in laboratory-scale Queso Fresco.
Food microbiology, Volume: 94		2021
Evaluation of paramagnetic beads coated with recombinant Listeria phage endolysin-derived cell-wall-binding domain proteins for separation of Listeria monocytogenes from raw milk in combination with culture-based and real-time polymerase chain reaction-ba
Foodborne pathogens and disease, Volume: 7, Issue: 9		2010
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]