clemizole has been researched along with Seizures in 4 studies
clemizole: was heading 1966-94 (see under BENZIMIDAZOLES 1966-90); use BENZIMIDAZOLES to search CLEMIZOLE 1966-94; a histamine H1- blocker used to treat allergies
clemizole : A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dravet syndrome is a catastrophic childhood epilepsy with early-onset seizures, delayed language and motor development, sleep disturbances, anxiety-like behaviour, severe cognitive deficit and an increased risk of fatality." | 5.46 | Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome. ( Baraban, SC; Griffin, A; Hamling, KR; Hong, S; Knupp, K; Lee, LP, 2017) |
| "Clemizole and trazodone were previously identified in a larval zebrafish model for Dravet syndrome." | 1.72 | Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder. ( Baraban, SC; Moog, M, 2022) |
| "Dravet syndrome is a catastrophic childhood epilepsy with early-onset seizures, delayed language and motor development, sleep disturbances, anxiety-like behaviour, severe cognitive deficit and an increased risk of fatality." | 1.46 | Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome. ( Baraban, SC; Griffin, A; Hamling, KR; Hong, S; Knupp, K; Lee, LP, 2017) |
| "Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development and persistent drug-resistant seizures." | 1.39 | Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. ( Baraban, SC; Dinday, MT; Hortopan, GA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moog, M | 1 |
| Baraban, SC | 3 |
| de Witte, P | 1 |
| Lagae, L | 1 |
| Dinday, MT | 1 |
| Hortopan, GA | 1 |
| Griffin, A | 1 |
| Hamling, KR | 1 |
| Knupp, K | 1 |
| Hong, S | 1 |
| Lee, LP | 1 |
4 other studies available for clemizole and Seizures
| Article | Year |
|---|---|
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder.
Topics: Animals; Anticonvulsants; Benzimidazoles; Disease Models, Animal; Humans; Larva; Munc18 Proteins; Ra | 2022 |
Serotonergic modulation as a pharmacological modality in the treatment of Dravet syndrome.
Topics: Benzimidazoles; Epilepsies, Myoclonic; Humans; Seizures; Serotonin | 2017 |
Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Topics: Animals; Anticonvulsants; Benzimidazoles; Bromides; Diazepam; Dioxolanes; Drug Evaluation, Preclinic | 2013 |
Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome.
Topics: Adolescent; Animals; Animals, Genetically Modified; Anticonvulsants; Benzazepines; Benzimidazoles; C | 2017 |