clemizole has been researched along with Hepatitis C in 4 studies
clemizole: was heading 1966-94 (see under BENZIMIDAZOLES 1966-90); use BENZIMIDAZOLES to search CLEMIZOLE 1966-94; a histamine H1- blocker used to treat allergies
clemizole : A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively.
Hepatitis C: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to identify the inhibitors of hepatitis C virus (HCV) replication with a novel scaffold via a mechanistically unbiased approach, we screened our in-house library composed of ∼6000 compounds with various chemical structures by using the renilla luciferase-linked genotype 2a reporter virus, and we identified a series of compounds containing an indole moiety that were active against HCV replication." | 3.80 | Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors. ( Choi, M; Jin, G; Kim, GW; Lee, C; Lee, K; Lee, S; Oh, JW; Son, S, 2014) |
| " Therefore, we investigated whether they could provide a more predictive assessment for clemizole, a drug in clinical development for the treatment of hepatitis C virus (HCV) infection." | 3.79 | Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. ( Angus, P; Chen, Y; Elazar, M; Fitch, WL; Glenn, J; Hu, Y; Idilman, R; Liu, M; Murphy, B; Nakamura, M; Nishimura, T; Nomura, T; Peltz, G; Pham, E; Stedman, C; Suemizu, H; Wu, M; Yurdaydin, C; Zheng, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, G | 1 |
| Lee, S | 1 |
| Choi, M | 1 |
| Son, S | 1 |
| Kim, GW | 1 |
| Oh, JW | 1 |
| Lee, C | 1 |
| Lee, K | 1 |
| Cannalire, R | 1 |
| Barreca, ML | 1 |
| Manfroni, G | 1 |
| Cecchetti, V | 1 |
| Einav, S | 1 |
| Gerber, D | 1 |
| Bryson, PD | 1 |
| Sklan, EH | 1 |
| Elazar, M | 2 |
| Maerkl, SJ | 1 |
| Glenn, JS | 1 |
| Quake, SR | 1 |
| Nishimura, T | 2 |
| Hu, Y | 1 |
| Wu, M | 1 |
| Pham, E | 1 |
| Suemizu, H | 1 |
| Liu, M | 1 |
| Idilman, R | 1 |
| Yurdaydin, C | 1 |
| Angus, P | 1 |
| Stedman, C | 1 |
| Murphy, B | 1 |
| Glenn, J | 1 |
| Nakamura, M | 1 |
| Nomura, T | 1 |
| Chen, Y | 1 |
| Zheng, M | 1 |
| Fitch, WL | 1 |
| Peltz, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1b, Open Label Study of the Safety, Tolerability Pharmacokinetics and Pharmacodynamics of 100 mg Clemizole Hydrochloride Administered Orally Twice a Day for 28 Days Immediately Prior to Initiation of Treatment With HCV Standard of Care Therapy in [NCT00945880] | Phase 1 | 12 participants (Actual) | Interventional | 2009-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for clemizole and Hepatitis C
| Article | Year |
|---|---|
A Journey around the Medicinal Chemistry of Hepatitis C Virus Inhibitors Targeting NS4B: From Target to Preclinical Drug Candidates.
Topics: Antiviral Agents; Drug Evaluation, Preclinical; Enzyme Inhibitors; Hepacivirus; Hepatitis C; High-Th | 2016 |
3 other studies available for clemizole and Hepatitis C
| Article | Year |
|---|---|
Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors.
Topics: Antiviral Agents; Cell Line; Drug Discovery; Genome, Viral; Hepacivirus; Hepatitis C; Humans; Indole | 2014 |
Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.
Topics: Amino Acid Sequence; Benzimidazoles; Genome, Viral; Hepacivirus; Hepatitis C; Hepatitis C Antibodies | 2008 |
Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction.
Topics: Animals; Antiviral Agents; Benzimidazoles; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors | 2013 |