clemizole has been researched along with Glioblastoma in 1 studies
clemizole: was heading 1966-94 (see under BENZIMIDAZOLES 1966-90); use BENZIMIDAZOLES to search CLEMIZOLE 1966-94; a histamine H1- blocker used to treat allergies
clemizole : A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clemizole was not only effective in blocking heterologously expressed TRPC5 homomers but also TRPC1:TRPC5 heteromers as well as native TRPC5-like currents in the U-87 glioblastoma cell line." | 1.40 | Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. ( Hill, K; Richter, JM; Schaefer, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richter, JM | 1 |
| Schaefer, M | 1 |
| Hill, K | 1 |
1 other study available for clemizole and Glioblastoma
| Article | Year |
|---|---|
Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5.
Topics: Benzimidazoles; Calcium; Cell Line, Tumor; Cell Membrane; Glioblastoma; HEK293 Cells; Humans; Patch- | 2014 |