clemizole has been researched along with Epilepsies, Myoclonic in 4 studies
clemizole: was heading 1966-94 (see under BENZIMIDAZOLES 1966-90); use BENZIMIDAZOLES to search CLEMIZOLE 1966-94; a histamine H1- blocker used to treat allergies
clemizole : A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively.
Epilepsies, Myoclonic: A clinically diverse group of epilepsy syndromes characterized either by myoclonic seizures or by myoclonus in association with other seizure types. Myoclonic epilepsy syndromes are divided into three subtypes based on etiology: familial, cryptogenic, and symptomatic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dravet syndrome is a catastrophic childhood epilepsy with early-onset seizures, delayed language and motor development, sleep disturbances, anxiety-like behaviour, severe cognitive deficit and an increased risk of fatality." | 5.46 | Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome. ( Baraban, SC; Griffin, A; Hamling, KR; Hong, S; Knupp, K; Lee, LP, 2017) |
| "Dravet syndrome is a catastrophic childhood epilepsy with early-onset seizures, delayed language and motor development, sleep disturbances, anxiety-like behaviour, severe cognitive deficit and an increased risk of fatality." | 1.46 | Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome. ( Baraban, SC; Griffin, A; Hamling, KR; Hong, S; Knupp, K; Lee, LP, 2017) |
| "Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development and persistent drug-resistant seizures." | 1.39 | Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. ( Baraban, SC; Dinday, MT; Hortopan, GA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Witte, P | 1 |
| Lagae, L | 1 |
| Neff, EP | 1 |
| Baraban, SC | 2 |
| Dinday, MT | 1 |
| Hortopan, GA | 1 |
| Griffin, A | 1 |
| Hamling, KR | 1 |
| Knupp, K | 1 |
| Hong, S | 1 |
| Lee, LP | 1 |
4 other studies available for clemizole and Epilepsies, Myoclonic
| Article | Year |
|---|---|
Serotonergic modulation as a pharmacological modality in the treatment of Dravet syndrome.
Topics: Benzimidazoles; Epilepsies, Myoclonic; Humans; Seizures; Serotonin | 2017 |
A new school of drug discovery.
Topics: Animals; Anti-Obesity Agents; Anticonvulsants; Benzazepines; Benzimidazoles; Disease Models, Animal; | 2017 |
Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Topics: Animals; Anticonvulsants; Benzimidazoles; Bromides; Diazepam; Dioxolanes; Drug Evaluation, Preclinic | 2013 |
Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome.
Topics: Adolescent; Animals; Animals, Genetically Modified; Anticonvulsants; Benzazepines; Benzimidazoles; C | 2017 |