positive regulation of cardiac muscle hypertrophy in response to stress

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of cardiac muscle hypertrophy in response to stress. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093]

Positive regulation of cardiac muscle hypertrophy in response to stress is a complex process that involves a variety of signaling pathways and transcription factors. The process is initiated by mechanical or biochemical stressors such as increased blood pressure, increased blood volume, or elevated levels of hormones like angiotensin II. These stressors activate signaling pathways such as the MAPK, PI3K/Akt, and calcineurin pathways. These pathways converge on transcription factors like NFAT, MEF2, and GATA4 which regulate the expression of genes involved in hypertrophy, including genes encoding contractile proteins, sarcomeric proteins, and structural proteins. The upregulation of these genes leads to an increase in the size and strength of cardiac myocytes, resulting in hypertrophy. However, chronic or excessive hypertrophy can lead to maladaptive remodeling of the heart, ultimately contributing to heart failure. The precise mechanisms by which stress-induced signaling pathways activate transcription factors and regulate gene expression in cardiac myocytes are still being elucidated, but involve complex interactions between these signaling pathways and various epigenetic regulators, including histone modifications and microRNAs. Therefore, the process of positive regulation of cardiac muscle hypertrophy in response to stress involves a multifaceted interplay of signaling pathways, transcription factors, and epigenetic mechanisms.'
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Proteins (2)

Compounds (8)