5-11-methenyltetrahydrohomofolate and Syndrome

5-11-methenyltetrahydrohomofolate has been researched along with Syndrome* in 1 studies

Other Studies

1 other study(ies) available for 5-11-methenyltetrahydrohomofolate and Syndrome

Article	Year
Modification by two genes of associations between general somatic health and incident depressive syndrome in older people. Psychosomatic medicine, 2009, Volume: 71, Issue:3 To investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-HTTLPR) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms) on the associations between general somatic morbidity and incidence of depression in an East Asian population with high frequencies of potential risk alleles.. With a 2-year prospective study of a community sample (N = 521) of older people (aged 65+), information on baseline number of health complaints, diagnosis of moderate/severe depressive syndrome (Geriatric Mental State), and genotypes for 5-HTTLPR and MTHFR C677T polymorphisms were ascertained. Interactions between somatic morbidity and the two genotypes were investigated for incident depression.. Incident depression was present in 63 (12%) and was associated with worse somatic health. Significant interactions between number of somatic complaints and both genotypes were observed. For the 5-HTTLPR genotypes, the association between the number of somatic disorders and depression was significant in s/s homozygotes (chi2 = 8.80 (1 df), p = .003) but not in heterozygotes (chi2 = 0.23, p = .634) or l/l homozygotes (chi2 = 0.04, p = .840). For the MTHFR genotypes, the association between the number of somatic disorders and depression was significant in T/T homozygotes (chi2 = 4.97, p = .026) but not in C/T heterozygotes (chi2 = 1.24, p = .265) or C/C homozygotes (chi2 = 1.04, p = .307).. These findings suggest that associations between general somatic morbidity and late-life depression are modified by at least two genes, and that elders with particular genotypes are at greater risk for onset of depression in the presence of somatic ill health. Topics: Aged; Chronic Disease; Depressive Disorder; DNA Primers; Female; Folic Acid; Genotype; Health Status; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Prospective Studies; Serotonin Plasma Membrane Transport Proteins; Severity of Illness Index; Somatoform Disorders; Syndrome	2009

Article

Year

Modification by two genes of associations between general somatic health and incident depressive syndrome in older people.

Psychosomatic medicine, 2009, Volume: 71, Issue:3

To investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-HTTLPR) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms) on the associations between general somatic morbidity and incidence of depression in an East Asian population with high frequencies of potential risk alleles.. With a 2-year prospective study of a community sample (N = 521) of older people (aged 65+), information on baseline number of health complaints, diagnosis of moderate/severe depressive syndrome (Geriatric Mental State), and genotypes for 5-HTTLPR and MTHFR C677T polymorphisms were ascertained. Interactions between somatic morbidity and the two genotypes were investigated for incident depression.. Incident depression was present in 63 (12%) and was associated with worse somatic health. Significant interactions between number of somatic complaints and both genotypes were observed. For the 5-HTTLPR genotypes, the association between the number of somatic disorders and depression was significant in s/s homozygotes (chi2 = 8.80 (1 df), p = .003) but not in heterozygotes (chi2 = 0.23, p = .634) or l/l homozygotes (chi2 = 0.04, p = .840). For the MTHFR genotypes, the association between the number of somatic disorders and depression was significant in T/T homozygotes (chi2 = 4.97, p = .026) but not in C/T heterozygotes (chi2 = 1.24, p = .265) or C/C homozygotes (chi2 = 1.04, p = .307).. These findings suggest that associations between general somatic morbidity and late-life depression are modified by at least two genes, and that elders with particular genotypes are at greater risk for onset of depression in the presence of somatic ill health.

Topics: Aged; Chronic Disease; Depressive Disorder; DNA Primers; Female; Folic Acid; Genotype; Health Status; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Prospective Studies; Serotonin Plasma Membrane Transport Proteins; Severity of Illness Index; Somatoform Disorders; Syndrome

2009