Compounds > sclerotiamide
Page last updated: 2024-11-12

sclerotiamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

sclerotiamide: related to the paraherquamides; isolated from the sclerotia of Aspergillus sclerotiorum; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10647785
CHEMBL ID511731
MeSH IDM0270494

Synonyms (5)

Synonym
(-)-sclerotiamide
sclerotiamide
CHEMBL511731
(1'r,3r,7's,9's,12's)-12'-hydroxy-7,7,10',10'-tetramethylspiro[1h-pyrano[2,3-g]indole-3,11'-3,13-diazatetracyclo[5.5.2.01,9.03,7]tetradecane]-2,2',14'-trione
bdbm50535809
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (7)

Processvia Protein(s)Taxonomy
protein quality control for misfolded or incompletely synthesized proteinsATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
response to temperature stimulusATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
response to radiationATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
response to heatATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
proteolysisATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
protein quality control for misfolded or incompletely synthesized proteinsATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
proteasomal protein catabolic processATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
positive regulation of programmed cell deathATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (6)

Processvia Protein(s)Taxonomy
ATP-dependent peptidase activityATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
serine-type endopeptidase activityATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
protein bindingATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
serine-type peptidase activityATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
identical protein bindingATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
ATPase bindingATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
cytoplasmATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
cytosolATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
membraneATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
endopeptidase Clp complexATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
HslUV protease complexATP-dependent Clp protease proteolytic subunitEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID355211Insecticidal activity against corn ear worm first instar larvae assessed as laterally shriveled in dead larvae at 200 ppm administered with standard test diet1996Journal of natural products, Nov, Volume: 59, Issue:11
Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID1634824Activation of Escherichia coli BLR (DE3) ClpP using beta casein as substrate at 50 uM preincubated for 15 mins followed by substrate addition measured every 30 mins by SDS-PAGE2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID1634825Activation of Bacillus subtilis ClpP expressed in Escherichia coli BL21 (DE3) using beta casein as substrate at 50 uM preincubated for 15 mins followed by substrate addition measured every 30 mins by SDS-PAGE2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID745815Cytotoxicity against human K562 cells by MTT assay2013Journal of natural products, May-24, Volume: 76, Issue:5
Alkaloids from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013.
AID355208Insecticidal activity against corn ear worm first instar larvae assessed as reduction in growth at 200 ppm administered with standard test diet relative to control1996Journal of natural products, Nov, Volume: 59, Issue:11
Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID355215Cytotoxicity against human NCI60 cells1996Journal of natural products, Nov, Volume: 59, Issue:11
Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID355213Insecticidal activity against corn ear worm first instar larvae assessed as bloating of area just prior to rear body in surviving larvae at 200 ppm administered with standard test diet1996Journal of natural products, Nov, Volume: 59, Issue:11
Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID1634823Activation of Escherichia coli BLR (DE3) ClpP using Abz-DFAPKMALVPYNO2 as substrate assessed as degradation of substrate peptide preincubated for 15 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID745814Cytotoxicity against human MCF7 cells by MTT assay2013Journal of natural products, May-24, Volume: 76, Issue:5
Alkaloids from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013.
AID667073Antifungal activity against Candida albicans DAY185 assessed as inhibition of biofilm formation after 48 hrs by XTT assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.
AID1634826Activation of Bacillus subtilis ClpP expressed in Escherichia coli BL21 (DE3) using FITC-beta casein as substrate assessed as degradation of substrate peptide at 50 uM preincubated for 15 mins followed by substrate addition measured every 30 mins for 2 hr2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID1634821Activation of Escherichia coli BLR (DE3) ClpP using bovine milk FITC-beta casein as substrate assessed as change in relative fluorescent units at 50 uM preincubated for 15 mins followed by substrate addition measured every 30 mins for 6 hrs by fluorescenc2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID355214Antifeedant activity against Carpophilus hemipterus adult assessed as reduction in feeding rate at 100 ppm1996Journal of natural products, Nov, Volume: 59, Issue:11
Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID745817Cytotoxicity against human HL60 cells by MTT assay2013Journal of natural products, May-24, Volume: 76, Issue:5
Alkaloids from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013.
AID1634831Ratio of EC50 for Escherichia coli BLR (DE3) ClpP using FITC-beta casein as substrate to ratio of EC50 for Escherichia coli ClpP using Abz-DFAPKMALVPYNO2 as substrate2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID355212Insecticidal activity against corn ear worm first instar larvae assessed as blackened in dead larvae at 200 ppm administered with standard test diet1996Journal of natural products, Nov, Volume: 59, Issue:11
Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID1634828Antibacterial activity against Escherichia coli M5418 harboring deltaacrB/deltaacrD/deltaacrEF::spc deltaemrBdeltaemrYdeltaentS::cam deltamacB deltamdtC deltamdtF mutant assessed as bacterial growth inhibition at 100 uM after 18 hrs by 2-fold dilution met2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID355209Insecticidal activity against corn ear worm first instar larvae assessed as mortality at 200 ppm administered with standard test diet1996Journal of natural products, Nov, Volume: 59, Issue:11
Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID1634822Activation of Escherichia coli BLR (DE3) ClpP using FITC-beta casein as substrate assessed as degradation of substrate peptide preincubated for 15 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID1634832Intrinsic proteolytic activity against fluorescein isothiocyanate-conjugated bovine milk beta casein at 50 uM preincubated for 15 mins followed by substrate addition measured every 30 mins for 6 hrs by fluorescence assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID745816Cytotoxicity against human A549 cells by MTT assay2013Journal of natural products, May-24, Volume: 76, Issue:5
Alkaloids from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013.
AID355210Insecticidal activity against corn ear worm first instar larvae assessed as cuticle/exoskeleton rupture in dead larvae at 200 ppm administered with standard test diet1996Journal of natural products, Nov, Volume: 59, Issue:11
Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID667072Antifungal activity against Candida albicans DAY185 assessed as lowest compound concentration causing =>80% reduction in cell viability after 48 hrs by XTT assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.
AID1634829Antibacterial activity against Pseudomonas aeruginosa PAO1116 harboring deltamexAB-oprM/deltamexCD-oprj/deltamexEF-oprN/deltaJK/deltamexXY/deltatriABC mutant assessed as bacterial growth inhibition at 100 uM after 18 hrs by 2-fold dilution method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's0 (0.00)29.6817
2010's4 (57.14)24.3611
2020's2 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.43 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
paraherquamide
paraherquamide: structure very similar to marcfortine A; RN given refers to the (1'alpha,5'abeta,7'beta,8'abeta,9'abeta)-isomer; RN for cpd without isomeric designation not avail 6/90		2.1310
farnesol
Farnesol: A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). (2-trans,6-trans)-farnesol : The (2-trans,6-trans)-stereoisomer of farnesol.. farnesol : A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.		2.0710farnesolplant metabolite
stephacidin a
stephacidin A: from Aspergillus ochraceus; structure in first source		7.0610
avrainvillamide
avrainvillamide: from Aspergillus sp.; structure in first source		2.07101-benzopyran
notoamide b
notoamide B: structure in first source		7.7830
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Lung
[description not available]		02.610
Lung Neoplasms
Tumors or cancer of the LUNG.		02.610