sclerotiamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

sclerotiamide: related to the paraherquamides; isolated from the sclerotia of Aspergillus sclerotiorum; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10647785
CHEMBL ID	511731
MeSH ID	M0270494

Synonyms (5)

Synonym
(-)-sclerotiamide
sclerotiamide
CHEMBL511731
(1'r,3r,7's,9's,12's)-12'-hydroxy-7,7,10',10'-tetramethylspiro[1h-pyrano[2,3-g]indole-3,11'-3,13-diazatetracyclo[5.5.2.01,9.03,7]tetradecane]-2,2',14'-trione
bdbm50535809

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (7)

Process	via Protein(s)	Taxonomy
protein quality control for misfolded or incompletely synthesized proteins	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
response to temperature stimulus	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
response to radiation	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
response to heat	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
proteolysis	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
protein quality control for misfolded or incompletely synthesized proteins	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
proteasomal protein catabolic process	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
positive regulation of programmed cell death	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (6)

Process	via Protein(s)	Taxonomy
ATP-dependent peptidase activity	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
serine-type endopeptidase activity	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
protein binding	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
serine-type peptidase activity	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
identical protein binding	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
ATPase binding	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Process	via Protein(s)	Taxonomy
cytoplasm	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
cytosol	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
membrane	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
endopeptidase Clp complex	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
HslUV protease complex	ATP-dependent Clp protease proteolytic subunit	Escherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (24)

Assay ID	Title	Year	Journal	Article
AID355211	Insecticidal activity against corn ear worm first instar larvae assessed as laterally shriveled in dead larvae at 200 ppm administered with standard test diet	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID1634824	Activation of Escherichia coli BLR (DE3) ClpP using beta casein as substrate at 50 uM preincubated for 15 mins followed by substrate addition measured every 30 mins by SDS-PAGE	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID1634825	Activation of Bacillus subtilis ClpP expressed in Escherichia coli BL21 (DE3) using beta casein as substrate at 50 uM preincubated for 15 mins followed by substrate addition measured every 30 mins by SDS-PAGE	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID745815	Cytotoxicity against human K562 cells by MTT assay	2013	Journal of natural products, May-24, Volume: 76, Issue:5	Alkaloids from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013.
AID355208	Insecticidal activity against corn ear worm first instar larvae assessed as reduction in growth at 200 ppm administered with standard test diet relative to control	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID355215	Cytotoxicity against human NCI60 cells	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID355213	Insecticidal activity against corn ear worm first instar larvae assessed as bloating of area just prior to rear body in surviving larvae at 200 ppm administered with standard test diet	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID1634823	Activation of Escherichia coli BLR (DE3) ClpP using Abz-DFAPKMALVPYNO2 as substrate assessed as degradation of substrate peptide preincubated for 15 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assay	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID745814	Cytotoxicity against human MCF7 cells by MTT assay	2013	Journal of natural products, May-24, Volume: 76, Issue:5	Alkaloids from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013.
AID667073	Antifungal activity against Candida albicans DAY185 assessed as inhibition of biofilm formation after 48 hrs by XTT assay	2012	Journal of natural products, Apr-27, Volume: 75, Issue:4	Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.
AID1634826	Activation of Bacillus subtilis ClpP expressed in Escherichia coli BL21 (DE3) using FITC-beta casein as substrate assessed as degradation of substrate peptide at 50 uM preincubated for 15 mins followed by substrate addition measured every 30 mins for 2 hr	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID1634821	Activation of Escherichia coli BLR (DE3) ClpP using bovine milk FITC-beta casein as substrate assessed as change in relative fluorescent units at 50 uM preincubated for 15 mins followed by substrate addition measured every 30 mins for 6 hrs by fluorescenc	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID355214	Antifeedant activity against Carpophilus hemipterus adult assessed as reduction in feeding rate at 100 ppm	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID745817	Cytotoxicity against human HL60 cells by MTT assay	2013	Journal of natural products, May-24, Volume: 76, Issue:5	Alkaloids from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013.
AID1634831	Ratio of EC50 for Escherichia coli BLR (DE3) ClpP using FITC-beta casein as substrate to ratio of EC50 for Escherichia coli ClpP using Abz-DFAPKMALVPYNO2 as substrate	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID355212	Insecticidal activity against corn ear worm first instar larvae assessed as blackened in dead larvae at 200 ppm administered with standard test diet	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID1634828	Antibacterial activity against Escherichia coli M5418 harboring deltaacrB/deltaacrD/deltaacrEF::spc deltaemrBdeltaemrYdeltaentS::cam deltamacB deltamdtC deltamdtF mutant assessed as bacterial growth inhibition at 100 uM after 18 hrs by 2-fold dilution met	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID355209	Insecticidal activity against corn ear worm first instar larvae assessed as mortality at 200 ppm administered with standard test diet	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID1634822	Activation of Escherichia coli BLR (DE3) ClpP using FITC-beta casein as substrate assessed as degradation of substrate peptide preincubated for 15 mins followed by substrate addition measured every 30 mins for 2 hrs by fluorescence assay	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID1634832	Intrinsic proteolytic activity against fluorescein isothiocyanate-conjugated bovine milk beta casein at 50 uM preincubated for 15 mins followed by substrate addition measured every 30 mins for 6 hrs by fluorescence assay	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID745816	Cytotoxicity against human A549 cells by MTT assay	2013	Journal of natural products, May-24, Volume: 76, Issue:5	Alkaloids from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013.
AID355210	Insecticidal activity against corn ear worm first instar larvae assessed as cuticle/exoskeleton rupture in dead larvae at 200 ppm administered with standard test diet	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
AID667072	Antifungal activity against Candida albicans DAY185 assessed as lowest compound concentration causing =>80% reduction in cell viability after 48 hrs by XTT assay	2012	Journal of natural products, Apr-27, Volume: 75, Issue:4	Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.
AID1634829	Antibacterial activity against Pseudomonas aeruginosa PAO1116 harboring deltamexAB-oprM/deltamexCD-oprj/deltamexEF-oprN/deltaJK/deltamexXY/deltatriABC mutant assessed as bacterial growth inhibition at 100 uM after 18 hrs by 2-fold dilution method	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (14.29)	18.2507
2000's	0 (0.00)	29.6817
2010's	4 (57.14)	24.3611
2020's	2 (28.57)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.43 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.51 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
paraherquamide paraherquamide: structure very similar to marcfortine A; RN given refers to the (1'alpha,5'abeta,7'beta,8'abeta,9'abeta)-isomer; RN for cpd without isomeric designation not avail 6/90	2.13	1
farnesol Farnesol: A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). (2-trans,6-trans)-farnesol : The (2-trans,6-trans)-stereoisomer of farnesol.. farnesol : A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.	2.07	1	farnesol	plant metabolite
stephacidin a stephacidin A: from Aspergillus ochraceus; structure in first source	7.06	1
avrainvillamide avrainvillamide: from Aspergillus sp.; structure in first source	2.07	1	1-benzopyran
notoamide b notoamide B: structure in first source	7.78	3

Condition	Indicated	Relationship Strength	Studies	Trials
Cancer of Lung [description not available]	0	2.6	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	0	2.6	1	0

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