Page last updated: 2024-08-07 20:18:59

Short transient receptor potential channel 1

A short transient receptor potential channel 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48995]

Synonyms

TrpC1;
Transient receptor protein 1;
TRP-1

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (1)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1h-pyrazole-4-carboxylateHomo sapiens (human)IC500.500011

Enables

This protein enables 7 target(s):

TargetCategoryDefinition
signaling receptor bindingmolecular functionBinding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]
monoatomic cation channel activitymolecular functionEnables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient. [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
calcium channel activitymolecular functionEnables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATPase bindingmolecular functionBinding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai]
inositol 1,4,5 trisphosphate bindingmolecular functionBinding to inositol 1,4,5 trisphosphate. [GOC:BHF, GOC:mah]
store-operated calcium channel activitymolecular functionA ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. [GOC:dph, GOC:tb, PMID:15788710]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 2 target(s):

TargetCategoryDefinition
receptor complexcellular componentAny protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]
cation channel complexcellular componentAn ion channel complex through which cations pass. [GOC:mah]

Involved In

This protein is involved in 7 target(s):

TargetCategoryDefinition
calcium ion transportbiological processThe directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
melanin biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. [GOC:curators]
positive regulation of release of sequestered calcium ion into cytosolbiological processAny process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. [GOC:ai]
regulation of cytosolic calcium ion concentrationbiological processAny process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. [GOC:ai, GOC:mah, GOC:rph]
response to calcium ionbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:ai]
calcium ion transmembrane transportbiological processA process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
regulation of cardiac conductionbiological processAny process that modulates the frequency, rate or extent of cardiac conduction. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]