1-bromo-2-chloroethane profile

## 1-Bromo-2-chloroethane: Structure, Properties, and Research Significance

1-Bromo-2-chloroethane is a colorless, volatile liquid with the chemical formula CH₂BrCH₂Cl. Its structure features a two-carbon chain with a bromine atom attached to one carbon and a chlorine atom attached to the other.

**Here are some key features and properties of 1-bromo-2-chloroethane:**

* **Molecular Weight:** 157.44 g/mol
* **Density:** 1.66 g/cm³
* **Boiling Point:** 107 °C
* **Solubility:** Insoluble in water but soluble in organic solvents like ethanol and diethyl ether
* **Reactivity:** 1-Bromo-2-chloroethane is a reactive compound that can undergo various reactions, including nucleophilic substitutions, elimination reactions, and free radical reactions.

**Why is 1-Bromo-2-chloroethane important for research?**

1-Bromo-2-chloroethane has several applications in research, primarily due to its ability to act as a **synthetic building block** for a variety of other molecules. Here are some key areas where this compound plays a role:

* **Organic Chemistry:** 1-Bromo-2-chloroethane is used in the synthesis of complex organic molecules, serving as a source of a bromoethyl group. Its reactivity allows for reactions like Grignard and Wittig reactions, which are crucial in organic synthesis.
* **Pharmaceutical Research:** The compound is used in the development of new drugs and pharmaceuticals. Its specific structure can be modified to create compounds with unique biological activities.
* **Materials Science:** Researchers utilize 1-Bromo-2-chloroethane in the synthesis of polymers and other materials with specific properties. For example, it can be used to introduce bromine functionalities into polymers, influencing their physical and chemical characteristics.
* **Environmental Research:** Due to its reactivity, 1-Bromo-2-chloroethane is also used in studies related to environmental pollution and degradation of organic compounds.

**Important Note:** 1-Bromo-2-chloroethane is a **hazardous** compound. It is flammable, corrosive, and potentially carcinogenic. Researchers handling this chemical should wear appropriate personal protective equipment (PPE) and work in a well-ventilated area.

**Conclusion:**

1-Bromo-2-chloroethane is a versatile compound with significant applications in various fields of research, particularly in organic chemistry, pharmaceutical science, and materials science. Its reactivity and ability to act as a synthetic building block make it a valuable tool for researchers striving to synthesize new and innovative molecules. However, its hazardous nature requires careful handling and appropriate safety precautions.

1-bromo-2-chloroethane : A haloalkane that is bromoethane substituted by chlorine at position 2. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	7849
CHEMBL ID	160255
CHEBI ID	19032
SCHEMBL ID	117238
MeSH ID	M0118482

Synonym
CHEBI:19032 ,
beta-chloroethyl bromide
2-bromoethyl chloride
2-bromo-1-chloroethane
1-chloro-2-bromoethane
s-chlorobromoethane
.beta.-chloroethyl bromide
nsc60186
nsc-60186
1,2-chlorobromoethane
2-chloroethyl bromide
ethylene chlorobromide
1,2-bromochloroethane
wln: g2e
inchi=1/c2h4brcl/c3-1-2-4/h1-2h
1-bromo-2-chloroethane
ethane, 1-bromo-2-chloro-
107-04-0
NCGC00091170-01
brn 0605265
ai3-52297
nsc 60186
caswell no. 436b
einecs 203-456-0
ccris 816
sym-chlorobromoethane
hsdb 6121
epa pesticide chemical code 042001
1-bromo-2-chloroethane, 98%
B0572
CHEMBL160255
NCGC00091170-02
AKOS005720772
unii-b2pdn2xo5u
b2pdn2xo5u ,
4-01-00-00155 (beilstein handbook reference)
cas-107-04-0
NCGC00257128-01
dtxsid4024775 ,
dtxcid904775
tox21_303193
tox21_201726
NCGC00259275-01
BBL011345
c2h4brcl
STL146435
ethylene bromochloride
FT-0607453
syn-chlorobromoethane
1-bromo-2-chloroethane [hsdb]
BR1051
SCHEMBL117238
ch2brch2cl
2-bromo-1-chloro-ethane
brch2ch2cl
bromo-2-chloroethane
2-chloroethylbromide
2-chloro-1-bromoethane
1-bromo 2-chloroethane
1-bromo 2-chloro ethane
2-chlorobromoethane
1-bromo-2-chloro-ethane
bromo 2 chloroethane
2-bromochloroethane
1-bromo-2-chloro ethane
2-bromo-l-chloroethane
1-chloro-2-bromo-ethane
Q-200110
F0001-0135
mfcd00000962
Q27109104
AMY25520
FS-4503
D95298
EN300-31848
1-bromo-2-chloroethane 1000 microg/ml in methanol

Role	Description
mutagen	An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
haloalkane	A halohydrocarbon that is an alkane in which at least one hydrogen atom has been replaced by with a halogen atom.
organobromine compound	A compound containing at least one carbon-bromine bond.
organochlorine compound	An organochlorine compound is a compound containing at least one carbon-chlorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	61.6448	0.3758	27.4851	61.6524	AID743217
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	44.6684	0.0010	24.5048	61.6448	AID588534
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	38.4531	0.0017	23.8393	78.1014	AID743083
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID37562	Induction of aneuploidy in Aspergillus nidulans.	1995	Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4	Molecular similarity matrices and quantitative structure-activity relationships: a case study with methodological implications.
AID19825	Partition coefficient (logP)	1995	Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4	Molecular similarity matrices and quantitative structure-activity relationships: a case study with methodological implications.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (12.50)	18.7374
1990's	4 (50.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	1 (12.50)	24.3611
2020's	1 (12.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ethylene dichloride ethylene dichloride: RN given refers to 1,2-isomer; structure given in first source. 1,2-dichloroethane : A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.	3.08	5	chloroethanes	hepatotoxic agent; mutagen; non-polar solvent
methylene bromide methylene bromide: RN given refers to parent cpd. dibromomethane : A member of the class of bromomethanes that is methane substituted by two bromo groups. It is produced by marine algae.	1.98	1	bromohydrocarbon; bromomethanes	algal metabolite; marine metabolite
bromoform bromoform: structure	1.98	1	bromohydrocarbon; bromomethanes
carbon tetrachloride Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	1.98	1	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant
4-nitroquinoline-1-oxide 4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.	1.99	1	C-nitro compound; quinoline N-oxide	carcinogenic agent
chloroform Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.	1.98	1	chloromethanes; one-carbon compound	carcinogenic agent; central nervous system drug; inhalation anaesthetic; non-polar solvent; refrigerant
hexachloroethane [no description available]	1.98	1	chlorocarbon; chloroethanes	carcinogenic agent; refrigerant
1,1,1-trichloroethane Trichloroethanes: Chlorinated ethanes which are used extensively as industrial solvents. They have been utilized in numerous home-use products including spot remover preparations and inhalant decongestant sprays. These compounds cause central nervous system and cardiovascular depression and are hepatotoxic. Include 1,1,1- and 1,1,2-isomers.. 1,1,1-trichloroethane : A member of the class of chloroethanes carrying three chloro substituents at position 1.	1.98	1	chloroethanes	polar solvent
ethane Ethane: A two carbon alkane with the formula H3C-CH3.. ethane : An alkane comprising of two carbon atoms.	3.39	7	alkane; gas molecular entity	plant metabolite; refrigerant
bromoethane bromoethane : A bromoalkane that is ethane carrying a bromo substituent. It is an alkylating agent used as a chemical intermediate in various organic syntheses.	1.98	1	bromoalkane; bromohydrocarbon; volatile organic compound	alkylating agent; carcinogenic agent; local anaesthetic; refrigerant; solvent
bromochloromethane bromochloromethane: inhibitor of ruminal methane production. bromochloromethane : A halomethane that is chloromethane in which one of the hydrogens has been replaced by a bromine atom.	1.98	1	halomethane
propane Propane: A three carbon alkane with the formula H3CCH2CH3.	2.06	1	alkane; gas molecular entity	food propellant
methylene chloride Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.. dichloromethane : A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.	2.39	2	chloromethanes; volatile organic compound	carcinogenic agent; polar aprotic solvent; refrigerant
bromodichloromethane bromodichloromethane: RN given refers to parent cpd. bromodichloromethane : A halomethane that is dichloromethane in which oneof the hydrogens has been replaced by a bromine atom. It occurs as a contaminant in drinking water.	1.98	1	halomethane	environmental contaminant; reagent
1,1-dichloroethane [no description available]	1.98	1	organochlorine compound
vinylidene chloride vinylidene chloride: potent hepatotoxin. 1,1-dichloroethene : A member of the class of chloroethenes that is ethene in which both of the hydrogens attached to one of the carbons are replaced by chlorines.	1.98	1	chloroethenes	carcinogenic agent; mouse metabolite; mutagen
bromotrichloromethane Bromotrichloromethane: A potent liver poison. In rats, bromotrichloromethane produces about three times the degree of liver microsomal lipid peroxidation as does carbon tetrachloride.	1.98	1
trichlorofluoromethane trichlorofluoromethane: refrigerant, aerosol propellant; RN given refers to parent cpd; structure. trichlorofluoromethane : A one-carbon compound that is methane in which the hydrogens have been replaced by three chlorine and one fluorine atom.	1.98	1	chlorofluorocarbon; halomethane	environmental contaminant; NMR chemical shift reference compound; NMR solvent; refrigerant
pentachloroethane [no description available]	1.98	1	chloroethanes	non-polar solvent
propylene dichloride propylene dichloride: Russian drug; structure. 1,2-dichloropropane : A chloroalkane that is propane in which a hydrogen from each of two adjacent carbons has been replaced by chlorines.	1.98	1	chloroalkane; volatile organic compound
2,3-dichloro-1-propene 2,3-dichloro-1-propene: soil fumigant	1.98	1
1,1,2-trichloroethane 1,1,2-trichloroethane: RN given refers to cpd with locants as specified. 1,1,2-trichloroethane : A member of the class of chloroethanes that is ethane substituted by chloro groups at positions 1, 1 and 2.	1.98	1	chloroethanes
trichloroethylene Trichloroethylene: A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment.. triol : A chemical compound containing three hydroxy groups.	1.98	1	chloroethenes	inhalation anaesthetic; mouse metabolite
1,1,2,2-tetrachloroethane 1,1,2,2-tetrachloroethane: see also record for tetrachloroethane. 1,1,2,2-tetrachloroethane : A member of the class of chloroethanes that is ethane substituted by chloro groups at positions 1, 1, 2 and 2.	1.98	1	chloroethanes
2-furoic acid 2-furoic acid: RN given refers to parent cpd. furoic acid : A monocarboxylic acid that consists of a furan ring having a single carboxylic acid group on any ring position and derivatives thereof.. 2-furoic acid : A furoic acid having the carboxylic acid group located at position 2.	2.02	1	furoic acid	bacterial xenobiotic metabolite; human xenobiotic metabolite; inhibitor; plant metabolite; Saccharomyces cerevisiae metabolite
1,2,3-trichloropropane [no description available]	1.98	1	organochlorine compound
ethylene dibromide Ethylene Dibromide: An effective soil fumigant, insecticide, and nematocide. In humans, it causes severe burning of skin and irritation of the eyes and respiratory tract. Prolonged inhalation may cause liver necrosis. It is also used in gasoline. Members of this group have caused liver and lung cancers in rodents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), 1,2-dibromoethane may reasonably be anticipated to be a carcinogen.. 1,2-dibromoethane : A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae.	2.67	3	bromoalkane; bromohydrocarbon	algal metabolite; carcinogenic agent; fumigant; marine metabolite; mouse metabolite; mutagen
butyl bromide [no description available]	1.98	1
butyl chloride butyl chloride: structure	1.98	1
1,3-dichloropropane 1,3-dichloropropane : A chloroalkane that is propane in which a hydrogen from each of the terminal methyl groups has been replaced by a chlorine.	1.98	1	chloroalkane; chlorohydrocarbon	environmental contaminant; nematicide
1-chloro-2-methylpropene [no description available]	1.98	1	organochlorine compound
1-chlorohexane [no description available]	1.98	1
3-chloro-2-methylprop-1-ene [no description available]	1.98	1	organochlorine compound
2,2-dichloropropane 2,2-dichloropropane: a water pollutant	1.98	1
2-nitrofluorene 2-nitrofluorene: RN given refers to cpd with locant with nitro moiety in 2 position. 2-nitrofluorene : A nitroarene that is fluorene substituted by a nitro group at position 2.	1.99	1	nitroarene	carcinogenic agent; mutagen
1,1,1,2-tetrachloroethane 1,1,1,2-tetrachloroethane: see also record for tetrachloroethane	1.98	1	chloroethanes
1-nitropyrene [no description available]	1.99	1	nitroarene	carcinogenic agent
chlorodibromomethane [no description available]	1.98	1	organochlorine compound
tetrachloroethylene Tetrachloroethylene: A chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.	1.98	1	chlorocarbon; chloroethenes	nephrotoxic agent
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.02	1
methylnitronitrosoguanidine Methylnitronitrosoguanidine: A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.. N-methyl-N'-nitro-N-nitrosoguanidine : An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position	1.99	1	nitroso compound	alkylating agent

1-bromo-2-chloroethane

Description

Cross-References

Synonyms (76)

Roles (1)

Drug Classes (3)

Protein Targets (3)

Potency Measurements

Bioassays (2)

Research

Studies (8)

Market Indicators

Research Demand Index: 41.52

Study Types