Page last updated: 2024-12-05
1,2,7,8-diepoxyoctane
Description
1,2,7,8-Diepoxyoctane is a **highly reactive, cyclic ether compound** with the chemical formula C8H12O2. It is characterized by the presence of two epoxide rings, which are three-membered cyclic ethers with a high degree of strain.
Here's why 1,2,7,8-diepoxyoctane is important for research:
* **Precursor to complex molecules:** Due to its reactivity, 1,2,7,8-diepoxyoctane serves as a versatile building block for the synthesis of various complex molecules, including polymers, pharmaceuticals, and natural products. The epoxide rings can be opened and modified by various chemical reactions, allowing for the introduction of diverse functionalities.
* **Probing biological systems:** The high reactivity of epoxides makes them useful for studying biological systems. 1,2,7,8-diepoxyoctane can be used to:
* **Investigate enzyme activity:** Epoxides are known to interact with various enzymes, especially those involved in detoxification pathways. Studying their reaction with 1,2,7,8-diepoxyoctane can provide insights into enzyme kinetics and mechanisms.
* **Label biomolecules:** The epoxide rings can be used to attach fluorescent probes or other tags to biomolecules, enabling their visualization and tracking in cellular processes.
* **Study cellular processes:** The reactivity of epoxides with cellular components allows researchers to investigate their effects on cell growth, differentiation, and signaling pathways.
**Safety Considerations:**
It's important to remember that 1,2,7,8-diepoxyoctane is a highly reactive and potentially hazardous compound. It should be handled with extreme care in a well-ventilated area using appropriate safety equipment.
**In summary**, 1,2,7,8-diepoxyoctane is a valuable compound for researchers working in various fields like organic synthesis, biochemistry, and cell biology. Its reactivity and versatility allow for the development of novel molecules, exploration of biological processes, and investigation of enzyme activity.
1,2,7,8-diepoxyoctane: difunctional alkylating agent; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 17048 |
| CHEBI ID | 23705 |
| SCHEMBL ID | 33715 |
| MeSH ID | M0060257 |
Synonyms (52)
| Synonym |
|---|
| 1,2:7,8-diepoxyoctane |
| oxirane, 2,2'-(1,4-butanediyl)bis- |
| 1,8-epoxyoctane |
| 1,8-diepoxyoctane |
| octane,2:7,8-diepoxy- |
| oxirane,2'-(1,4-butanediyl)bis- |
| wln: t3otj b4- bt3otj |
| nsc269058 |
| nsc-269058 |
| 2426-07-5 |
| CHEBI:23705 |
| 2,2'-butane-1,4-diyldioxirane |
| 1,2-epoxy-7,8-epoxyoctane |
| ai3-52822 |
| einecs 219-375-9 |
| 1,2,7,8-diepoxyoctane |
| ccris 963 |
| nsc 269058 |
| brn 0104873 |
| 1,7-octadiene diepoxide |
| octane, 1,2:7,8-diepoxy- |
| 2,2'-(1,4-butanediyl)bisoxirane |
| 1,2,7,8-diepoxyoctane, 97% |
| 2-[4-(oxiran-2-yl)butyl]oxirane |
| D1586 |
| unii-4ij1m5w7ll |
| 5-19-01-00229 (beilstein handbook reference) |
| 4ij1m5w7ll , |
| 2-(4-oxiran-2-ylbutyl)oxirane |
| AKOS015999611 |
| FT-0606268 |
| GC10199 |
| 2426-o7-5 |
| SCHEMBL33715 |
| J-503793 |
| mfcd00005155 |
| SY031422 |
| J-640001 |
| 2-[4-(2-oxiranyl)butyl]oxirane # |
| J2.154G , |
| 2,2'-(1,4-butanediyl)bis(oxirane) |
| 2,2'-tetramethylenebisoxirane |
| J-800001 |
| BCP21857 |
| 1,4-buthylenebis(oxirane);1,7-octadiene diepoxide;oxirane, 2,2'-(1,4-butanediyl)bis- |
| F10176 |
| 1,4-di(oxiran-2-yl)butane |
| Q27109807 |
| DTXSID00862928 |
| CS-11846 |
| CS-0313243 |
| ?1,2,7,8-diepoxyoctane |
Research Excerpts
Dosage Studied
Roles (1)
| Role | Description |
|---|
| mutagen | An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (1)
| Class | Description |
|---|
| epoxide | Any cyclic ether in which the oxygen atom forms part of a 3-membered ring. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 21.55
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 21.55 (24.57) | | Research Supply Index | 2.20 (2.92) | | Research Growth Index | 4.45 (4.65) | | Search Engine Demand Index | 18.60 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |