Page last updated: 2024-09-27

Mansonelliasis

Infection with nematodes of the genus MANSONELLA. Symptoms include pruritus, headache, and articular swelling.

Synonyms(1)

Synonym
Mansonelliasis

Research Excerpts

Overview

ExcerptReference
"Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment."( Aranha Camargo, JS; Aranha Camargo, LM; Barreto Crispim, Pd; Basano, Sde A; Fontes, G; Mattos Ferreira, Rde G; Medeiros, JF; Parente Araújo, MP; Pires Parente, MS; Souza Vera, LJ, 2014)
"The treatment of mansonelliasis is still a challenge because there are few clinical trials for the treatment of the disease."( Camargo, LMA; de Almeida Basano, S; de Godoi Mattos Ferreira, R; de Oliveira Laudisse, MC; de Souza Almeida Aranha Camargo, J; Fontes, G; Medeiros, JF; Pereira, AR, 2018)

Research

Studies (74)

TimeframeStudies, This Condition (%)All Conditions %
pre-199018 (24.32)23.3326
1990's10 (13.51)12.5806
2000's23 (31.08)18.1394
2010's17 (22.97)28.8240
2020's6 (8.11)9.53
DrugIndicatedRelationship StrengthStudiesTrials
albendazole0medium63
chloroquine0low10
diethylcarbamazine0low80
mebendazole0low60
praziquantel0low20
thiabendazole0low30
prednisolone0low20
dehydroepiandrosterone0low10
phencyclidine0low10
lucanthone hydrochloride0low10
dehydroepiandrosterone sulfate0low10
levamisole0low10
quinine0low10
beta-escin0low10
loa0low270
dextrothyroxine0medium257
pyrethrins0low10
apyrase0low10
exudates0low10

Protein Targets (324)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Telomerase reverse transcriptase0101
Amyloid-beta precursor protein0202
Reverse transcriptase/RNaseH 0202
Chain A, Beta-lactamase1001
Luciferase3003
glp-1 receptor, partial2002
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma5005
ATAD5 protein, partial2002
Fumarate hydratase3003
TDP1 protein8008
GLI family zinc finger 36006
AR protein7007
caspase 7, apoptosis-related cysteine protease2002
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor3003
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha8008
farnesoid X nuclear receptor5005
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha8008
polyprotein3003
67.9K protein2002
peroxisome proliferator activated receptor gamma4004
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
caspase-32002
IDH12002
euchromatic histone-lysine N-methyltransferase 23003
aryl hydrocarbon receptor7007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)3003
nuclear receptor subfamily 1, group I, member 24004
Histone H2A.x3003
cellular tumor antigen p53 isoform a4004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
chromobox protein homolog 12002
nuclear factor erythroid 2-related factor 2 isoform 23003
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 27007
histone deacetylase 9 isoform 33003
heat shock protein beta-12002
mitogen-activated protein kinase 13003
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
geminin5005
Vif0001
peripheral myelin protein 223003
survival motor neuron protein isoform d4004
muscleblind-like protein 1 isoform 13003
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
lamin isoform A-delta105005
neuropeptide S receptor isoform A3003
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40809
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump010010
Interferon beta6006
Cellular tumor antigen p534004
Integrin beta-33003
Integrin alpha-IIb3003
Methionine aminopeptidase0303
Glutamate receptor 23003
Fatty-acid amide hydrolase 10303
Inositol monophosphatase 12002
Canalicular multispecific organic anion transporter 10707
ATPase family AAA domain-containing protein 55005
Ataxin-26006
thioredoxin reductase4004
PPM1D protein3003
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
Spike glycoprotein0112
Replicase polyprotein 1ab0112
glucose-6-phosphate 1-dehydrogenase isoform b0101
flap endonuclease 12002
Transmembrane protease serine 20112
Dihydrofolate reductase 0101
DNA ligase0101
Riboflavin-binding protein0011
Major prion protein0011
Histidine-rich protein PFHRP-II0203
Procathepsin L0112
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
Cytochrome P450 3A40101
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0101
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Spike glycoprotein0101
Replicase polyprotein 1ab0112
Muscarinic acetylcholine receptor M10101
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
DNA ligase 10101
Muscarinic acetylcholine receptor M30101
Serine/threonine-protein kinase mTOR0101
Nuclear receptor subfamily 4 group A member 20011
Beta-secretase 10101
Spike glycoprotein2114
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 20202
Sigma intracellular receptor 20101
Phosphoethanolamine N-methyltransferase0101
Sigma non-opioid intracellular receptor 10202
Angiotensin-converting enzyme 2 0112
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
Chain A, BCL-2-RELATED PROTEIN A10011
Smad31001
EWS/FLI fusion protein3003
G2002
peroxisome proliferator-activated receptor delta3003
huntingtin isoform 22002
tyrosine-protein kinase Yes1001
nuclear factor erythroid 2-related factor 2 isoform 15005
nuclear receptor ROR-gamma isoform 11001
relaxin receptor 1 isoform 11001
bcl-2-like protein 11 isoform 10011
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
HLA class I histocompatibility antigen, B alpha chain 2002
Deoxycytidine kinase0001
Adenosine receptor A30101
Rap guanine nucleotide exchange factor 41001
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
SMAD family member 23003
SMAD family member 33003
estrogen receptor 2 (ER beta)4004
cytochrome P450 family 3 subfamily A polypeptide 46006
cytochrome P450 2D65005
thyroid stimulating hormone receptor2002
Sex hormone-binding globulin0011
Beta-glucuronidase0101
Corticosteroid-binding globulin0202
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase0202
Alpha-synuclein1001
TAR DNA-binding protein 431001
G-protein coupled bile acid receptor 10033
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
Solute carrier organic anion transporter family member 1A40102
Solute carrier organic anion transporter family member 1A50001
Steryl-sulfatase0001
Multidrug resistance-associated protein 1 0001
Solute carrier organic anion transporter family member 1A10102
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
ATP-binding cassette sub-family C member 110001
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1B20001
Solute carrier organic anion transporter family member 1B10001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Ferritin light chain1001
Chain A, Cruzipain1001
endonuclease IV1001
Microtubule-associated protein tau1001
nonstructural protein 11001
glucocerebrosidase1001
Bloom syndrome protein isoform 12002
peripheral myelin protein 22 isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d1001
DNA polymerase beta1001
DNA polymerase iota isoform a (long)2002
M-phase phosphoprotein 82002
Ultraspiracle0202
20-hydroxy-ecdysone receptor 0202
eyes absent homolog 2 isoform a1001
Ecdysone receptor0101
Protein ultraspiracle0101
Ecdysone receptor0101
Ultraspiracle 0101
20-hydroxy-ecdysone receptor 0101
Ultraspiracle protein 0101
20-hydroxy-ecdysone receptor 0101
dopamine D1 receptor1001
atrial natriuretic peptide receptor 1 precursor1001
Alkaline phosphatase, tissue-nonspecific isozyme0202
Alkaline phosphatase, placental type0101
Alkaline phosphatase, tissue-nonspecific isozyme 0202
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Phospholipase A-2-activating protein0101
ATP-dependent phosphofructokinase2002
Vitamin D3 receptor0112
GALC protein1001
aldehyde dehydrogenase 1 family, member A12002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
cytochrome P450 2C9 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lethal factor (plasmid)1001
Tyrosine-protein kinase ABL10202
Proto-oncogene tyrosine-protein kinase Src0202
Vascular endothelial growth factor receptor 20101
Histamine H2 receptor1001
Disintegrin and metalloproteinase domain-containing protein 171001
Calmodulin-domain protein kinase 10101
Adenosine deaminase0101
Adenosine deaminase 0101
Adenosine deaminase 0101
Chain A, Immunoglobulin0011
Chain B, Immunoglobulin0011
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor M30011
Muscarinic acetylcholine receptor M40011
Muscarinic acetylcholine receptor M50011
Muscarinic acetylcholine receptor M20011
Muscarinic acetylcholine receptor M10012
Cytochrome P450 2B60101
Sodium-dependent serotonin transporter0101
Muscarinic acetylcholine receptor M40012
Delta-type opioid receptor0001
Kappa-type opioid receptor0001
Glutamate receptor ionotropic, NMDA 1 0202
Lysosomal Pro-X carboxypeptidase0101
Mu-type opioid receptor0001
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0203
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
Muscarinic acetylcholine receptor M50012
Muscarinic acetylcholine receptor M30012
Muscarinic acetylcholine receptor M20012
Sigma non-opioid intracellular receptor 10202
Glutamate receptor ionotropic, NMDA 3A0202
regulator of G-protein signaling 41001
arylsulfatase A1001
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b0011
cytochrome P450 3A4 isoform 12002
muscarinic acetylcholine receptor M11001
Gamma-aminobutyric acid receptor subunit pi2002
Bile salt export pump0101
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Mineralocorticoid receptor 0213
Androgen receptor0202
Cytochrome P450 2C9 0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
Solute carrier family 22 member 10101
Solute carrier family 22 member 20102
Solute carrier family 22 member 1 0202
Solute carrier family 22 member 20101
Potassium channel subfamily K member 20101
Albumin0011
ATP-dependent translocase ABCB10203
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D60202
Cytochrome P450 2D30101
5-hydroxytryptamine receptor 70101
Solute carrier family 22 member 10203
Cytochrome P450 2D40101
Solute carrier family 22 member 20202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Methionine aminopeptidase0101
Chain A, 2-oxoglutarate Oxygenase1001
BRCA11001
pregnane X receptor1001
thyroid stimulating hormone receptor1001
P531001
pyruvate kinase1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
cytochrome P450 2D6 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
cytochrome P450 2C19 precursor1001
thyroid hormone receptor beta isoform a1001
ras-related protein Rab-9A1001
Cytochrome P450 1A20101
Endothelin receptor type B1001
Endothelin-1 receptor1001
Methionine aminopeptidase 20101
Nuclear receptor ROR-gamma1001
Methionine aminopeptidase 10112
Peptidyl-prolyl cis-trans isomerase FKBP1A0011
Multidrug and toxin extrusion protein 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]