Page last updated: 2024-09-28

Diastema

An abnormal opening or fissure between two adjacent teeth.

Synonyms(2)

Synonym
Diastema
Diastemata

Research Excerpts

Research

Studies (89)

TimeframeStudies, This Condition (%)All Conditions %
pre-199018 (20.22)23.3326
1990's15 (16.85)12.5806
2000's20 (22.47)18.1394
2010's34 (38.20)28.8240
2020's2 (2.25)9.53
DrugIndicatedRelationship StrengthStudiesTrials
nickel0low50
phosphoric acid0low20
urea0low10
thalidomide0low10
urethane0low10
thyroxine0low10
isoprene0low120
methylmethacrylate0low10
methylprednisolone0low10
triethylene glycol dimethacrylate0low10
bisphenol a-glycidyl methacrylate0medium31
nile blue0low10
neodymium0low10
samarium0low10
technetium0low10
titanium0low80
argon0low10
yttrium0low10
zirconium0low30
tricalcium phosphate0low10
phenyl acetate0low10
carbamide peroxide0low10
cobalt0low10
c & b metabond0low10
proline0low10
cortisone0low10
inositol 3-phosphate0low140
bromochloroacetic acid0low20
capsaicin0low10
lithium0low10
phenylephrine hydrochloride0low30
aluminum0medium11
cerotate0low10
boron0low10
emerin0low10
aluminum oxide0medium11
jaw0low40
vendex0low10
heliosit0low10
tetracycline0low10
feldspar0low60
cyclosporine0low10
exudates0low10

Protein Targets (353)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase1001
glp-1 receptor, partial3003
hypoxia-inducible factor 1 alpha subunit5005
RAR-related orphan receptor gamma110011
SMAD family member 23003
ATAD5 protein, partial2002
SMAD family member 33003
TDP1 protein7007
GLI family zinc finger 3110011
TSHR protein1001
AR protein110011
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 38008
progesterone receptor7007
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 1110011
retinoid X nuclear receptor alpha9009
estrogen-related nuclear receptor alpha100010
farnesoid X nuclear receptor4004
pregnane X nuclear receptor8008
estrogen nuclear receptor alpha130013
67.9K protein3003
peroxisome proliferator-activated receptor delta7007
peroxisome proliferator activated receptor gamma8008
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
IDH14004
aryl hydrocarbon receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
thyroid stimulating hormone receptor4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)6006
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
thyroid hormone receptor beta isoform 27007
heat shock protein beta-14004
DNA polymerase eta isoform 12002
geminin6006
Voltage-dependent calcium channel gamma-2 subunit3003
Cellular tumor antigen p536006
Glutamate receptor 23003
Alpha-synuclein2103
ATPase family AAA domain-containing protein 53003
Ataxin-23003
aldehyde dehydrogenase 1 family, member A17007
nuclear factor erythroid 2-related factor 2 isoform 19009
Nuclear receptor ROR-gamma3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
15-lipoxygenase, partial3003
phosphopantetheinyl transferase3003
GLS protein2002
Microtubule-associated protein tau1001
glucocerebrosidase2002
chromobox protein homolog 14004
mitogen-activated protein kinase 12002
DNA polymerase iota isoform a (long)2002
nuclear receptor ROR-gamma isoform 12002
peripheral myelin protein 223003
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 13003
transient receptor potential cation channel subfamily V member 11001
lamin isoform A-delta106006
Gamma-aminobutyric acid receptor subunit pi3003
Transient receptor potential cation channel subfamily V member 10213
Lysine-specific histone demethylase 1A0101
Bile salt export pump0606
NADH-ubiquinone oxidoreductase chain 10101
Cytochrome P450 1A20101
Polyunsaturated fatty acid 5-lipoxygenase0101
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Cannabinoid receptor 10101
Acetylcholinesterase0101
Prostaglandin G/H synthase 10101
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Cannabinoid receptor 2 0101
Spike glycoprotein3003
D(2) dopamine receptor0011
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Inositol monophosphatase 11001
Potassium voltage-gated channel subfamily A member 10112
Corticotropin-releasing factor receptor 20101
Transient receptor potential cation channel subfamily V member 10214
GABA theta subunit3003
Transient receptor potential cation channel subfamily V member 40011
Gamma-aminobutyric acid receptor subunit epsilon3003
Transient receptor potential cation channel subfamily V member 20011
ATP-dependent phosphofructokinase3003
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, BCL-2-RELATED PROTEIN A10011
Chain A, Cruzipain1001
Luciferase3003
acid sphingomyelinase1001
interleukin 82002
acetylcholinesterase3003
PAX80001
pregnane X receptor2002
USP1 protein, partial2002
caspase 7, apoptosis-related cysteine protease2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
PINK11001
thyroid stimulating hormone receptor2002
cytochrome P450 family 3 subfamily A polypeptide 43003
G3003
cytochrome P450 2D62002
Parkin1001
heat shock protein 900011
caspase-32002
euchromatic histone-lysine N-methyltransferase 25005
calcineurin A1, putative0011
activating transcription factor 61001
Histone H2A.x4004
cytochrome P450 2D6 isoform 11001
hepatocyte nuclear factor 4-alpha isoform 20101
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
perilipin-50101
thyroid hormone receptor beta isoform a4004
perilipin-10101
nuclear factor erythroid 2-related factor 2 isoform 22002
potassium voltage-gated channel subfamily H member 2 isoform d1001
transcriptional regulator ERG isoform 31001
huntingtin isoform 21001
importin subunit beta-1 isoform 11001
ubiquitin-conjugating enzyme E2 N0101
nuclear factor NF-kappa-B p105 subunit isoform 11001
flap endonuclease 12002
protein AF-9 isoform a0001
snurportin-11001
melanocortin receptor 40101
CAAX prenyl protease0001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
bcl-2-related protein A10101
urokinase plasminogen activator surface receptor precursor1001
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
DNA polymerase kappa isoform 13003
glycogen synthase kinase-3 alpha0001
hexokinase HKDC10101
DNA repair protein RAD52 homolog isoform a0001
bcl-2-like protein 11 isoform 10011
lethal factor (plasmid)3003
Synaptojanin-20101
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Synaptojanin-10101
Solute carrier family 22 member 30101
Glutathione reductase, mitochondrial0102
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Integrin beta-32002
72 kDa type IV collagenase0202
Integrin alpha-IIb2002
Matrix metalloproteinase-90101
Trypanothione reductase0101
Histamine H2 receptor1001
TAR DNA-binding protein 432002
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase0101
Multidrug and toxin extrusion protein 20101
Rap guanine nucleotide exchange factor 41001
Inositol hexakisphosphate kinase 13003
Multidrug and toxin extrusion protein 10202
Spermine oxidase0101
cytochrome P450 2C9, partial3003
endonuclease IV1001
dopamine D1 receptor1001
thioredoxin reductase3003
regulator of G-protein signaling 41001
peripheral myelin protein 22 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
M-phase phosphoprotein 81001
muscarinic acetylcholine receptor M11001
Glucocorticoid receptor0404
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Chymotrypsinogen A0101
PPM1D protein1001
nonstructural protein 11001
bromodomain adjacent to zinc finger domain 2B1001
nuclear receptor subfamily 1, group I, member 21001
muscleblind-like protein 1 isoform 11001
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Nuclear receptor subfamily 1 group I member 20022
Androgen receptor0202
Canalicular multispecific organic anion transporter 10202
Nuclear receptor subfamily 1 group I member 20011
Chain A, 2-oxoglutarate Oxygenase1001
GALC protein1001
beta-2 adrenergic receptor1001
Bloom syndrome protein isoform 12002
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Ornithine transcarbamylase, mitochondrial0101
2-dehydropantoate 2-reductase0101
Proto-oncogene tyrosine-protein kinase Src0101
Nociceptin receptor0101
Fe(3+)-Zn(2+) purple acid phosphatase0101
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Glutamate receptor ionotropic, NMDA 1 0101
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Proton-coupled amino acid transporter 10101
Amino acid transporter0101
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
Caspase-71001
caspase-31001
90-kda heat shock protein beta HSP90 beta, partial0101
EWS/FLI fusion protein3003
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
Stromelysin-10101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
Solute carrier family 22 member 80001
P2Y purinoceptor 120101
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Solute carrier family 22 member 70001
Cereblon isoform 40202
arylsulfatase A1001
Prostaglandin G/H synthase 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Prostaglandin G/H synthase 20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
apical membrane antigen 1, AMA11001
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 32002
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Urease subunit alpha0101
Urease subunit beta0101
Olfactory receptor 51E20011
vitamin D3 receptor isoform VDRA1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]