Cattle Plague

A viral disease of cloven-hoofed animals caused by MORBILLIVIRUS. It may be acute, subacute, or chronic with the major lesions characterized by inflammation and ulceration of the entire digestive tract. The disease was declared successfully eradicated worldwide in 2010.

Synonyms(2)

Synonym
Cattle Plague
Rinderpest

Research Excerpts

Overview

Excerpt	Reference
"Rinderpest, or cattle plague, is caused by Rinderpest virus (RPV), which is related most closely to human Measles virus (MV), both being members of the genus Morbillivirus, a group of viruses known to have strong immunosuppressive effects in vitro and in vivo."	( Barrett, T; Cosby, SL; Heaney, J, 2005)

Research

Studies (47)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	30 (63.83)	23.3326
1990's	7 (14.89)	12.5806
2000's	7 (14.89)	18.1394
2010's	3 (6.38)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
methane	low	1	0
chlorine	low	1	0
formaldehyde	low	1	0
iodine	low	1	0
phenol	low	1	0
aspirin	low	1	0
diminazene	low	1	0
propiolactone	low	1	0
mefenamic acid	low	1	0
sulfamethazine	low	1	0
sulfapyridine	low	1	0
chloramphenicol	low	1	0
sabinene	low	1	0
streptomycin	low	1	0
magnesium sulfate	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
biotin	low	1	0
glycogen	low	1	0
dienestrol	low	1	0
mtt formazan	low	1	0
bilirubin	low	1	0
phenylephrine hydrochloride	low	1	0
diminazene aceturate	low	1	0
formazans	low	1	0
chlortetracycline	low	1	0
oxytetracycline, anhydrous	low	1	0
agar	low	2	0
eye	low	2	0
concanavalin a	medium	1	1

Protein Targets (395)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	3	0	0	3
thioredoxin reductase	3	0	0	3
GLS protein	4	0	0	4
AR protein	12	0	0	12
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
thyroid stimulating hormone receptor	3	0	0	3
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
EWS/FLI fusion protein	2	0	0	2
glucocorticoid receptor [Homo sapiens]	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
estrogen-related nuclear receptor alpha	7	0	0	7
estrogen nuclear receptor alpha	11	0	0	11
cytochrome P450 2D6	6	0	0	6
glucocerebrosidase	1	0	0	1
peroxisome proliferator-activated receptor delta	6	0	0	6
Rac1 protein	0	0	1	1
IDH1	2	0	0	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
Bloom syndrome protein isoform 1	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	3	0	0	3
DNA polymerase kappa isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	2	0	0	2
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	6	0	6
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	7	0	7
Carbonic anhydrase 2	0	7	0	7
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	3	1	0	4
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	3	1	0	4
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Adenosine receptor A1	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	1	0	5
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, Cruzipain	2	0	0	2
phosphopantetheinyl transferase	3	0	0	3
USP1 protein, partial	4	0	0	4
Microtubule-associated protein tau	4	0	0	4
vitamin D3 receptor isoform VDRA	6	0	0	6
caspase-1 isoform alpha precursor	1	0	0	1
lamin isoform A-delta10	5	0	0	5
Caspase-7	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
RAR-related orphan receptor gamma	9	0	0	9
apical membrane antigen 1, AMA1	2	0	0	2
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Chain A, Ferritin light chain	3	0	0	3
acetylcholinesterase	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
TDP1 protein	6	0	0	6
GLI family zinc finger 3	5	0	0	5
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
progesterone receptor	3	0	0	3
retinoid X nuclear receptor alpha	7	0	0	7
farnesoid X nuclear receptor	4	0	0	4
67.9K protein	1	0	0	1
peroxisome proliferator activated receptor gamma	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
caspase-3	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
activating transcription factor 6	4	0	0	4
thyrotropin-releasing hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
thyroid hormone receptor beta isoform 2	7	0	0	7
heat shock protein beta-1	3	0	0	3
mitogen-activated protein kinase 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
nuclear receptor ROR-gamma isoform 1	2	0	0	2
survival motor neuron protein isoform d	4	0	0	4
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Cellular tumor antigen p53	4	0	0	4
Glutamate receptor 2	3	0	0	3
Caspase-2	0	0	1	1
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
pregnane X nuclear receptor	6	0	0	6
G	4	0	0	4
aryl hydrocarbon receptor	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
geminin	6	0	0	6
streptokinase A precursor	0	0	1	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Cytochrome P450 3A4	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Inositol hexakisphosphate kinase 1	4	0	0	4
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	4	0	0	4
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Protein-arginine deiminase type-4	0	5	0	5
Chain A, Beta-lactamase	3	0	0	3
Luciferase	4	0	0	4
glp-1 receptor, partial	2	0	0	2
15-lipoxygenase, partial	1	0	0	1
Estrogen receptor 1	0	0	1	1
Smad3	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
TPA: protein transporter TIM10	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
lysosomal alpha-glucosidase preproprotein	3	0	0	3
cellular tumor antigen p53 isoform a	3	0	0	3
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
cytochrome P450 3A4 isoform 1	4	0	0	4
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	4	0	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	3	0	0	3
Neuronal acetylcholine receptor subunit beta-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit delta	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	0	4
Alpha-synuclein	1	0	0	1
Histamine H2 receptor	2	0	0	2
Spike glycoprotein	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-2	4	0	0	4
Rap guanine nucleotide exchange factor 4	1	0	0	1
GABA theta subunit	4	0	0	4
Gamma-aminobutyric acid receptor subunit epsilon	4	0	0	4
Cathepsin B	0	1	0	1
Furin	0	1	0	1
Amiloride-sensitive amine oxidase [copper-containing]	0	1	0	1
Diamine acetyltransferase 1	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Acid-sensing ion channel 2	0	1	0	1
histone deacetylase 9 isoform 3	2	0	0	2
nonstructural protein 1	2	0	0	2
Histone H2A.x	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
chromobox protein homolog 1	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Aldo-keto reductase family 1 member B10	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Beta-lactamase	0	1	0	1
Myc proto-oncogene protein	0	1	0	1
Cytochrome P450 2C9	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Cytochrome P450 2J2	0	1	0	1
Aldo-keto reductase family 1 member C2	0	2	0	2
Aldo-keto reductase family 1 member C1	0	2	0	2
Peroxisome proliferator-activated receptor alpha	1	0	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
regulator of G-protein signaling 4	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
thyroid hormone receptor beta isoform a	2	0	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
DNA polymerase beta	1	0	0	1
flap endonuclease 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
alpha-galactosidase	1	0	0	1
Polyphenol oxidase 2	0	0	0	1
Carbonic anhydrase 12	0	1	0	1
Endolysin	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Cannabinoid receptor 1	0	1	0	1
Carbonic anhydrase 6	0	4	0	4
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	3	0	3
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
GALC protein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
peripheral myelin protein 22	2	0	0	2
5-hydroxytryptamine receptor 2A	0	0	1	1
Bile salt export pump	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
Cystine/glutamate transporter	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
BRCA1	1	0	0	1
pregnane X receptor	1	0	0	1
ATAD5 protein, partial	1	0	0	1
P53	1	0	0	1
pyruvate kinase	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
Cytochrome P450 1A2	0	1	0	1
Methionine aminopeptidase	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Methionine aminopeptidase 2	0	1	0	1
Methionine aminopeptidase 1	0	1	1	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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