oroidin and ageliferin

oroidin has been researched along with ageliferin* in 2 studies

Other Studies

2 other study(ies) available for oroidin and ageliferin

ArticleYear
Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors.
    Molecular oral microbiology, 2014, Volume: 29, Issue:5

    Porphyromonas gingivalis is one of the main etiological organisms in periodontal disease. On oral surfaces P. gingivalis is a component of multispecies biofilm communities and can modify the pathogenic potential of the community as a whole. Accumulation of P. gingivalis in communities is facilitated by interspecies binding and communication with the antecedent colonizer Streptococcus gordonii. In this study we screened a library of small molecules to identify structures that could serve as lead compounds for the development of inhibitors of P. gingivalis community development. Three small molecules were identified that effectively inhibited accumulation of P. gingivalis on a substratum of S. gordonii. The structures of the small molecules are derived from the marine alkaloids oroidin and bromoageliferin and contain a 2-aminoimidazole or 2-aminobenzimidazole moiety. The most active compounds reduced expression of mfa1 and fimA in P. gingivalis, genes encoding the minor and major fimbrial subunits, respectively. These fimbrial adhesins are necessary for P. gingivalis co-adhesion with S. gordonii. These results demonstrate the potential for a small molecular inhibitor-based approach to the prevention of diseases associated with P. gingivalis.

    Topics: Bacterial Adhesion; Bacterial Proteins; Benzimidazoles; Biofilms; Carbon-Sulfur Lyases; Fimbriae Proteins; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Imidazoles; Microbial Interactions; Microscopy, Confocal; Pili, Sex; Porphyromonas gingivalis; Pyrroles; Small Molecule Libraries; Streptococcus gordonii

2014
Studies toward the total synthesis of the oroidin dimers.
    Organic & biomolecular chemistry, 2009, Aug-21, Volume: 7, Issue:16

    A Diels-Alder/rearrangement sequence is described for the construction of the core ring systems of several oroidin dimers, including ageliferin and palau'amine.

    Topics: Alkaloids; Dimerization; Guanidines; Imidazoles; Marine Biology; Polymers; Pyrroles; Spiro Compounds

2009