Compounds > 4,5-dibromo-2-pyrrolic acid
Page last updated: 2024-11-08

4,5-dibromo-2-pyrrolic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4,5-dibromo-2-pyrrolic acid: isol from marine sponge Agelas flabelliformis; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID161830
CHEMBL ID397590
SCHEMBL ID1518075
MeSH IDM0170847

Synonyms (27)

Synonym
EN300-26697
nsc-320005
nsc320005
34649-21-3
carboxylic acid,5-dibromopyrrole-2- (b713395k067)
dbpa
CHEMBL397590
AKOS000118089
4,5-dibromo-1h-pyrrole-2-carboxylic acid
1h-pyrrole-2-carboxylic acid, 4,5-dibromo-
nsc 320005
4,5-dibromo-2-pyrrolic acid
FT-0679969
10X-0701
ZUROCNHARMFRKA-UHFFFAOYSA-N
mfcd01348229
SCHEMBL1518075
4,5-dibromo-1h-pyrrole-2-carboxylicacid
AKOS025394642
J-514072
DTXSID40188210
4,5-dibromopyrrole-2-carboxylic acid
SB62319
A874912
CS-0451417
E84393
Z227972132
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (41)

Assay IDTitleYearJournalArticle
AID355648Immunosuppressive activity against mouse splenocytes assessed as [3H]thymidine incorporation at 15.6 ug/ml after 88 hrs by liquid scintillation counting
AID355645Immunosuppressive activity against mouse splenocytes assessed as [3H]thymidine incorporation at 125 ug/ml after 88 hrs by liquid scintillation counting
AID355646Immunosuppressive activity against mouse splenocytes assessed as [3H]thymidine incorporation at 62.5 ug/ml after 88 hrs by liquid scintillation counting
AID355652Immunosuppressive activity against mouse splenocytes assessed as [3H]thymidine incorporation at 1.0 ug/ml after 88 hrs by liquid scintillation counting
AID309303Cytotoxicity against rat L6 cells after 72 hrs2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID355668Immunosuppressive activity against concanavalin A-activated mouse splenocytes assessed as [3H]thymidine incorporation at 125 ug/ml after 72 hrs by liquid scintillation counting
AID355659Cytotoxicity against mouse splenocytes assessed as cell viability at 15.6 ug/ml after 88 hrs by MTT assay
AID355654Cytotoxicity against mouse splenocytes assessed as cell viability at 500 ug/ml after 88 hrs by MTT assay
AID355676Immunosuppressive activity against concanavalin A-activated mouse splenocytes assessed as [3H]thymidine incorporation at 0.5 ug/ml after 72 hrs by liquid scintillation counting
AID355655Cytotoxicity against mouse splenocytes assessed as cell viability at 250 ug/ml after 88 hrs by MTT assay
AID309300Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by Alamar blue assay2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID355662Cytotoxicity against mouse splenocytes assessed as cell viability at 2.0 ug/ml after 88 hrs by MTT assay
AID355663Cytotoxicity against mouse splenocytes assessed as cell viability at 1.0 ug/ml after 88 hrs by MTT assay
AID355647Immunosuppressive activity against mouse splenocytes assessed as [3H]thymidine incorporation at 31.3 ug/ml after 88 hrs by liquid scintillation counting
AID355644Immunosuppressive activity against mouse splenocytes assessed as [3H]thymidine incorporation at 250 ug/ml after 88 hrs by liquid scintillation counting
AID355669Immunosuppressive activity against concanavalin A-activated mouse splenocytes assessed as [3H]thymidine incorporation at 62.5 ug/ml after 72 hrs by liquid scintillation counting
AID355661Cytotoxicity against mouse splenocytes assessed as cell viability at 3.9 ug/ml after 88 hrs by MTT assay
AID355666Immunosuppressive activity against concanavalin A-activated mouse splenocytes assessed as [3H]thymidine incorporation at 500 ug/ml after 72 hrs by liquid scintillation counting
AID309298Inhibition of Plasmodium falciparum FabI2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID355672Immunosuppressive activity against concanavalin A-activated mouse splenocytes assessed as [3H]thymidine incorporation at 7.8 ug/ml after 72 hrs by liquid scintillation counting
AID355675Immunosuppressive activity against concanavalin A-activated mouse splenocytes assessed as [3H]thymidine incorporation at 1.0 ug/ml after 72 hrs by liquid scintillation counting
AID355656Cytotoxicity against mouse splenocytes assessed as cell viability at 125 ug/ml after 88 hrs by MTT assay
AID355674Immunosuppressive activity against concanavalin A-activated mouse splenocytes assessed as [3H]thymidine incorporation at 2.0 ug/ml after 72 hrs by liquid scintillation counting
AID309301Antitrypanosomal activity against Trypanosoma cruzi after 72 hrs2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID355664Cytotoxicity against mouse splenocytes assessed as cell viability at 0.5 ug/ml after 88 hrs by MTT assay
AID355643Immunosuppressive activity against mouse splenocytes assessed as [3H]thymidine incorporation at 500 ug/ml after 88 hrs by liquid scintillation counting
AID355673Immunosuppressive activity against concanavalin A-activated mouse splenocytes assessed as [3H]thymidine incorporation at 3.9 ug/ml after 72 hrs by liquid scintillation counting
AID355657Cytotoxicity against mouse splenocytes assessed as cell viability at 62.5 ug/ml after 88 hrs by MTT assay
AID355665Cytotoxicity against mouse splenocytes assessed as cell viability at 0.3 ug/ml after 88 hrs by MTT assay
AID355650Immunosuppressive activity against mouse splenocytes assessed as [3H]thymidine incorporation at 3.9 ug/ml after 88 hrs by liquid scintillation counting
AID355651Immunosuppressive activity against mouse splenocytes assessed as [3H]thymidine incorporation at 2.0 ug/ml after 88 hrs by liquid scintillation counting
AID355671Immunosuppressive activity against concanavalin A-activated mouse splenocytes assessed as [3H]thymidine incorporation at 15.6 ug/ml after 72 hrs by liquid scintillation counting
AID309299Antimalarial activity against chloroquine-resistant, pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID309302Antileishmanial activity against Leishmania donovani after 72 hrs by Alamar blue assay2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID355660Cytotoxicity against mouse splenocytes assessed as cell viability at 7.8 ug/ml after 88 hrs by MTT assay
AID355653Immunosuppressive activity against mouse splenocytes assessed as [3H]thymidine incorporation at 0.5 ug/ml after 88 hrs by liquid scintillation counting
AID355658Cytotoxicity against mouse splenocytes assessed as cell viability at 31.3 ug/ml after 88 hrs by MTT assay
AID355677Immunosuppressive activity against concanavalin A-activated mouse splenocytes assessed as [3H]thymidine incorporation at 0.3 ug/ml after 72 hrs by liquid scintillation counting
AID355670Immunosuppressive activity against concanavalin A-activated mouse splenocytes assessed as [3H]thymidine incorporation at 31.3 ug/ml after 72 hrs by liquid scintillation counting
AID355649Immunosuppressive activity against mouse splenocytes assessed as [3H]thymidine incorporation at 7.8 ug/ml after 88 hrs by liquid scintillation counting
AID355667Immunosuppressive activity against concanavalin A-activated mouse splenocytes assessed as [3H]thymidine incorporation at 250 ug/ml after 72 hrs by liquid scintillation counting
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.47 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
propionic acid
propionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.		2.1510saturated fatty acid;
short-chain fatty acid		antifungal drug
taurine
[no description available]		2.0310amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
bisbenzimidazole
Bisbenzimidazole: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.		2.2510bibenzimidazole;
N-methylpiperazine		anthelminthic drug;
fluorochrome
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		2.0310phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
triclosan
[no description available]		2.0310aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols		antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.9740pyrrole;
secondary amine
melarsoprol
Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.		2.0310triazines
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		2.0310furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
benzonidazole
benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.		2.0310C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug
sceptrin
sceptrin: structure given in first source; isolated from marine sponges of the genus Agelas; RN from CHEMLINE		2.0210pyrroles;
secondary carboxamide
oroidin
oroidin: from marine sponges of the genus Agelas; structure in first source		2.7130pyrroles;
secondary carboxamide		metabolite
hymenidin
hymenidin: serotonergic receptor antagonist from Okinawan marine sponge Hymeniacidon; structure given in first source		210
bromopyruvate
[no description available]		2.15102-oxo monocarboxylic acid anion
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.1510
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.1510