Compounds > sceptrin

Page last updated: 2024-12-08

sceptrin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

sceptrin: structure given in first source; isolated from marine sponges of the genus Agelas; RN from CHEMLINE [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	157394
CHEMBL ID	307456
CHEBI ID	80954
MeSH ID	M0207439

Synonyms (7)

Synonym
CHEMBL307456
chebi:80954 ,
sceptrin
C17166
79638-16-7
DTXSID00276460
Q15424768

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

Class	Description
pyrroles	An azole that includes only one N atom and no other heteroatom as a part of the aromatic skeleton.
secondary carboxamide	A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (9)

Assay ID	Title	Year	Journal	Article
AID379936	Antiviral activity against HIV1 in human PBM cells	2006	Journal of natural products, Dec, Volume: 69, Issue:12	Cyclic heptapeptides from the Jamaican sponge Stylissa caribica.
AID379938	Antileishmanial activity against Leishmania donovani	2006	Journal of natural products, Dec, Volume: 69, Issue:12	Cyclic heptapeptides from the Jamaican sponge Stylissa caribica.
AID477229	Cytotoxicity against human KB cells at 30 uM	2010	Journal of natural products, Apr-23, Volume: 73, Issue:4	Agelastatin E, agelastatin F, and benzosceptrin C from the marine sponge Agelas dendromorpha.
AID468185	Displacement of [3H]BQ-123 from human ETA receptor in human SK-N-MC cells at 100 ug/ml after 60 mins by scintillation counting	2009	Journal of natural products, Dec, Volume: 72, Issue:12	5-OHKF and NorKA, depsipeptides from a Hawaiian collection of Bryopsis pennata: binding properties for NorKA to the human neuropeptide Y Y1 receptor.
AID379927	Antifungal activity against Cryptococcus neoformans	2006	Journal of natural products, Dec, Volume: 69, Issue:12	Cyclic heptapeptides from the Jamaican sponge Stylissa caribica.
AID468188	Displacement of [3H]NPY from neuropeptide Y1 receptor in human SK-N-MC cells at 10 ug/ml after 60 mins by scintillation counting	2009	Journal of natural products, Dec, Volume: 72, Issue:12	5-OHKF and NorKA, depsipeptides from a Hawaiian collection of Bryopsis pennata: binding properties for NorKA to the human neuropeptide Y Y1 receptor.
AID468187	Displacement of [3H]NPY from neuropeptide Y1 receptor in human SK-N-MC cells at 100 ug/ml after 60 mins by scintillation counting	2009	Journal of natural products, Dec, Volume: 72, Issue:12	5-OHKF and NorKA, depsipeptides from a Hawaiian collection of Bryopsis pennata: binding properties for NorKA to the human neuropeptide Y Y1 receptor.
AID379937	Antimycobacterial activity against Mycobacterium tuberculosis at 128 ug/mL	2006	Journal of natural products, Dec, Volume: 69, Issue:12	Cyclic heptapeptides from the Jamaican sponge Stylissa caribica.
AID468186	Displacement of [3H]BQ-123 from human ETA receptor in human SK-N-MC cells at 10 ug/ml after 60 mins by scintillation counting	2009	Journal of natural products, Dec, Volume: 72, Issue:12	5-OHKF and NorKA, depsipeptides from a Hawaiian collection of Bryopsis pennata: binding properties for NorKA to the human neuropeptide Y Y1 receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (10.00)	18.2507
2000's	11 (55.00)	29.6817
2010's	6 (30.00)	24.3611
2020's	1 (5.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	19 (95.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
thymine [no description available]	2.05	1	0	pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	1.98	1	0	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	5.33	17	0	pyrrole; secondary amine
quadricyclane quadricyclane: structure in first source	7.02	1	0
4,5-dibromo-2-pyrrolic acid 4,5-dibromo-2-pyrrolic acid: isol from marine sponge Agelas flabelliformis; structure given in first source	2.02	1	0
agelastatin a agelastatin A: structure in first source	2.05	1	0
manzacidin a manzacidin A: structure in first source	2.05	1	0
bibp 3226 BIBP 3226: a selective non-peptide neuropeptide Y Y1 receptor antagonist; structure given in first source; BIBP-3435 is the S-enantiomer	2.05	1	0
clathrodin clathrodin: structure given in first source; isolated from marine sponges of the genus Agelas	1.98	1	0
succinyl-trialanine-4-nitroanilide succinyl-trialanine-4-nitroanilide: synthetic substrate of porcine pancreatic elastase	2.41	1	0
oroidin oroidin: from marine sponges of the genus Agelas; structure in first source	2.92	4	0	pyrroles; secondary carboxamide	metabolite
chlorhexidine Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.. chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.	2.05	1	0	biguanides; monochlorobenzenes	antibacterial agent; antiinfective agent
plakortide f plakortide F: from Plakortis halichondrioides; structure given in first source	2.05	1	0
massadine massadine: a geranylgeranyltransferase type I inhibitor from the marine sponge Stylissa aff. massa.; structure in first source. massadine : An alkaloid isolated from Stylissa massa.	7.1	1	0	alkaloid; guanidines; organobromine compound; pyrrolecarboxamide	animal metabolite; EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor; marine metabolite
phakellistatin 13 phakellistatin 13: isolated from the marine sponge Phakellia; structure in first source	2.03	1	0	oligopeptide
ageliferin ageliferin: structure in first source	2.94	4	0
endothelins [no description available]	2.05	1	0
palau'amine palau'amine: structure in first source	2.02	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Extravascular Hemolysis [description not available]	0	1.98	1	0
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	0	1.98	1	0