Compounds > clathrodin
Page last updated: 2024-12-11

clathrodin

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Description

clathrodin: structure given in first source; isolated from marine sponges of the genus Agelas [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5388709
CHEMBL ID465679
SCHEMBL ID13036741
MeSH IDM0207440

Synonyms (16)

Synonym
nsc-638206
nsc638206
n-[(e)-3-(2-imino-1,3-dihydroimidazol-4-yl)allyl]-1h-pyrrole-2-carboxamide
n-(3-(2-imino-2,3-dihydro-1h-imidazol-4-yl)-2-propenyl)-1h-pyrrole-2-carboxamide
clathrodin
CHEMBL465679
n-[(e)-3-(2-amino-1h-imidazol-5-yl)prop-2-enyl]-1h-pyrrole-2-carboxamide
135383-64-1
1h-pyrrole-2-carboxamide, n-(3-(2-amino-1h-imidazol-4-yl)-2-propenyl)-, (e)-
SCHEMBL13036741
bdbm50456973
CS-0065478
n-[(2e)-3-(2-amino-1h-imidazol-5-yl)prop-2-en-1-yl]-1h-pyrrole-2-carboxamide
EN300-7456509
HY-116436
AKOS040748152

Research Excerpts

Overview

Clathrodin is a marine alkaloid. It is believed to be a modulator of voltage-gated sodium channels.

ExcerptReferenceRelevance
"Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (Na(V)) channels. "( Action of clathrodin and analogues on voltage-gated sodium channels.
Chan-Porter, F; Ilaš, J; Kikelj, D; Kirby, R; Madge, D; Peigneur, S; Tytgat, J; Zidar, N; Zula, A, 2014)		2.25
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (6)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Potassium voltage-gated channel subfamily A member 6Homo sapiens (human)IC50 (µMol)30.00003.70004.30004.9000AID1379140
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)IC50 (µMol)30.00000.00203.19698.0000AID1379137
Potassium voltage-gated channel subfamily A member 4Homo sapiens (human)IC50 (µMol)30.00002.10003.70005.3000AID1379138
Potassium voltage-gated channel subfamily A member 5Homo sapiens (human)IC50 (µMol)30.00000.03003.73009.0000AID1379139
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (50)

Processvia Protein(s)Taxonomy
potassium ion transportPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
regulation of dopamine secretionPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
neuronal action potentialPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
sensory perception of painPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
optic nerve structural organizationPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
cerebral cortex developmentPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
corpus callosum developmentPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
regulation of circadian sleep/wake cycle, non-REM sleepPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
protein homooligomerizationPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
regulation of postsynaptic membrane potentialPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
potassium ion export across plasma membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
regulation of presynaptic membrane potentialPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
action potentialPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
potassium ion transportPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
protein homooligomerizationPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
action potentialPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
potassium ion transportPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
optic nerve developmentPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
corpus callosum developmentPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
protein homooligomerizationPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
action potentialPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
potassium ion transportPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
protein homooligomerizationPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
regulation of presynaptic membrane potentialPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
action potentialPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
potassium ion transportPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
response to hypoxiaPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
Notch signaling pathwayPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
response to mechanical stimulusPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
response to organic substancePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
regulation of vasoconstrictionPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
regulation of membrane potentialPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
response to hydrogen peroxidePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
regulation of potassium ion transportPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
regulation of insulin secretionPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
protein homooligomerizationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
negative regulation of cytosolic calcium ion concentrationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
potassium ion homeostasisPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
response to hyperoxiaPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
membrane hyperpolarizationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
regulation of atrial cardiac muscle cell membrane repolarizationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
atrial cardiac muscle cell action potentialPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
membrane repolarization during bundle of His cell action potentialPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
membrane repolarization during SA node cell action potentialPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
regulation of heart rate by cardiac conductionPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
potassium ion export across plasma membranePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
membrane repolarization during atrial cardiac muscle cell action potentialPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cyclePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
positive regulation of myoblast proliferationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
action potentialPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
startle responsePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
regulation of muscle contractionPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
neuroblast proliferationPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
protein localizationPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cell communication by electrical couplingPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
magnesium ion homeostasisPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
neuronal action potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
optic nerve developmentPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
hippocampus developmentPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cerebral cortex developmentPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
corpus callosum developmentPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
neuronal signal transductionPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
regulation of membrane potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
neuromuscular processPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of painPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of touchPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
protein homooligomerizationPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
regulation of postsynaptic membrane potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
axon developmentPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cellular response to magnesium ionPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
membrane repolarization during action potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
regulation of presynaptic membrane potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
action potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (18)

Processvia Protein(s)Taxonomy
voltage-gated potassium channel activityPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
potassium channel activityPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
outward rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
kinesin bindingPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
voltage-gated potassium channel activityPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
voltage-gated monoatomic ion channel activityPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
outward rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
voltage-gated potassium channel activityPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
potassium ion bindingPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
signaling receptor bindingPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
outward rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
protein kinase bindingPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
alpha-actinin bindingPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
voltage-gated potassium channel activity involved in bundle of His cell action potential repolarizationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarizationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
voltage-gated potassium channel activity involved in SA node cell action potential repolarizationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
scaffold protein bindingPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
voltage-gated potassium channel activityPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
disordered domain specific bindingPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (38)

Processvia Protein(s)Taxonomy
endoplasmic reticulum membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
lamellipodiumPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
axonPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
dendritePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
lamellipodium membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
neuronal cell body membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
paranodal junctionPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
presynaptic membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
axon initial segmentPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
perikaryonPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
axon terminusPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
juxtaparanode region of axonPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
calyx of HeldPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
postsynaptic membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
glutamatergic synapsePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
axon terminusPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
dendritePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
juxtaparanode region of axonPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
cytosolPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
intracellular membrane-bounded organellePotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
axon terminusPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
potassium channel complexPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
presynaptic membranePotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
calyx of HeldPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
membrane raftPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
postsynaptic membranePotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
glutamatergic synapsePotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
axonPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
axonPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
axon initial segmentPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
dendritic spinePotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
axonPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
caveolaPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
Golgi apparatusPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
cell surfacePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
intercalated discPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
Z discPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
membrane raftPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
intracellular canaliculusPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
perinuclear region of cytoplasmPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
potassium channel complexPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
intercalated discPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
endoplasmic reticulumPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cytosolPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cell surfacePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
apical plasma membranePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cell junctionPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
dendritePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cytoplasmic vesiclePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
paranode region of axonPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
presynaptic membranePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
neuronal cell bodyPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
axon initial segmentPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
perikaryonPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
axon terminusPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
juxtaparanode region of axonPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
calyx of HeldPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
synapsePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
postsynaptic membranePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
anchoring junctionPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
glutamatergic synapsePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
dendritePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
paranode region of axonPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
synapsePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
juxtaparanode region of axonPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
neuronal cell bodyPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID1379150Inhibition of rat Kv10.1 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379149Inhibition of rat Kv1.6 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379146Inhibition of rat Kv1.3 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379139Inhibition of human Kv1.5 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379144Inhibition of rat Kv1.1 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379140Inhibition of human Kv1.6 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379145Inhibition of rat Kv1.2 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379148Inhibition of rat Kv1.5 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379136Inhibition of human Kv1.2 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379138Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379147Inhibition of rat Kv1.4 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379135Inhibition of human Kv1.1 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379137Inhibition of human Kv1.3 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's0 (0.00)29.6817
2010's8 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.92 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.92)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		2.1310amino-acid anion
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		3.76100pyrrole;
secondary amine
hempa
Hempa: A chemosterilant agent that is anticipated to be a carcinogen.		2.0810phosphoramideinsect sterilant;
mutagen
sceptrin
sceptrin: structure given in first source; isolated from marine sponges of the genus Agelas; RN from CHEMLINE		1.9810pyrroles;
secondary carboxamide
oroidin
oroidin: from marine sponges of the genus Agelas; structure in first source		3.1550pyrroles;
secondary carboxamide		metabolite
hymenidin
hymenidin: serotonergic receptor antagonist from Okinawan marine sponge Hymeniacidon; structure given in first source		2.5220
ConditionIndicatedRelationship StrengthStudiesTrials