Page last updated: 2024-12-08
manzacidin a
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
manzacidin A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 179267 |
| CHEMBL ID | 1095258 |
| SCHEMBL ID | 13700792 |
| MeSH ID | M0444763 |
Synonyms (10)
| Synonym |
|---|
| inchi=1/c12h14brn3o4/c1-12(3-9(10(17)18)15-6-16-12)5-20-11(19)8-2-7(13)4-14-8/h2,4,6,9,14h,3,5h2,1h3,(h,15,16)(h,17,18)/t9-,12+/m0/s |
| CHEMBL1095258 |
| manzacidin a |
| (-)-manzacidin a |
| manzacidine a |
| 134029-41-7 |
| (-)-manzacidine a |
| SCHEMBL13700792 |
| 6-{[(4-bromo-1h-pyrrole-2-carbonyl)oxy]methyl}-6-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid |
| DTXSID20928393 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (5)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1680922 | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability at 0.001 to 10 uM after 24 hrs by MTT assay | 2020 | Journal of natural products, 07-24, Volume: 83, Issue:7 | Futunamine, a Pyrrole-Imidazole Alkaloid from the Sponge |
| AID1680920 | Neuroprotective activity against TBHP-induced cytotoxicity in human SH-SY5Y cells assessed as increase in cell viability at 0.001 uM after 6 hrs by MTT assay | 2020 | Journal of natural products, 07-24, Volume: 83, Issue:7 | Futunamine, a Pyrrole-Imidazole Alkaloid from the Sponge |
| AID1680921 | Cytotoxicity against mouse BV-2 cells assessed as reduction in cell viability at 0.001 to 10 uM after 24 hrs by MTT assay | 2020 | Journal of natural products, 07-24, Volume: 83, Issue:7 | Futunamine, a Pyrrole-Imidazole Alkaloid from the Sponge |
| AID1680917 | Neuroprotective activity against TBHP-induced human SH-SY5Y cells assessed as decrease in ROS production at 1 uM after 6 hrs by DCFH-DA dye based spectrophotometric assay relative to control | 2020 | Journal of natural products, 07-24, Volume: 83, Issue:7 | Futunamine, a Pyrrole-Imidazole Alkaloid from the Sponge |
| AID477229 | Cytotoxicity against human KB cells at 30 uM | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Agelastatin E, agelastatin F, and benzosceptrin C from the marine sponge Agelas dendromorpha. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (9)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.15
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.15) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (11.11%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (88.89%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||