Compounds > dibromophakellstatin
Page last updated: 2024-11-12

dibromophakellstatin

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Description

dibromophakellstatin: from the Indian Ocean sponge, Phakellia mauritiana; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10500579
CHEMBL ID390234
SCHEMBL ID14442127
MeSH IDM0273625

Synonyms (6)

Synonym
dibromophakellstatin
(+/-)-dibromophakellstatin
CHEMBL390234
(-)-dibromophakellstatin
SCHEMBL14442127
(1r,5s)-7,8-dibromo-2,4,6,12-tetrazatetracyclo[10.3.0.01,5.06,10]pentadeca-7,9-diene-3,11-dione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (32)

Assay IDTitleYearJournalArticle
AID402523Cytotoxicity against human OVCAR5 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID671270Inhibition of chymotryptic-like of purified human 20S proteasome using Suc-LLVY-AMC as substrate after 30 mins by fluorescence assay2012Journal of natural products, May-25, Volume: 75, Issue:5
Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasome.
AID292869Antiproliferative activity against human MEXF 394NL cells2007Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
Antitumor activity of the marine natural product dibromophakellstatin in vitro.
AID671273Inhibition of chymotryptic-like of purified human 20S immunoproteasome2012Journal of natural products, May-25, Volume: 75, Issue:5
Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasome.
AID292858Antiproliferative activity against human CNXF 498NL cells2007Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
Antitumor activity of the marine natural product dibromophakellstatin in vitro.
AID402512Cytotoxicity against human K562 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402526Cytotoxicity against human PC3 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402521Cytotoxicity against human SNB75 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402508Cytotoxicity against human A498 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402518Cytotoxicity against human HCT116 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402506Cytotoxicity against human OVCAR-3 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402511Cytotoxicity against human SK-MEL-5 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402515Cytotoxicity against human NCI-H226 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID292854Antiproliferative activity against human SF268 cells2007Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
Antitumor activity of the marine natural product dibromophakellstatin in vitro.
AID402525Cytotoxicity against human 786-0 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402513Cytotoxicity against human A549 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402524Cytotoxicity against human OVCAR8 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402507Cytotoxicity against human SF295 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402529Cytotoxicity against human Hs 578T cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402520Cytotoxicity against human SF539 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID292874Antiproliferative activity against human OVXF 899L cells2007Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
Antitumor activity of the marine natural product dibromophakellstatin in vitro.
AID402509Cytotoxicity against human H460 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402516Cytotoxicity against human NCI-H522 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID292863Antiproliferative activity against human LXF 529L cells2007Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
Antitumor activity of the marine natural product dibromophakellstatin in vitro.
AID402510Cytotoxicity against human KM20L2 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID671271Inhibition of caspase-like of purified human 20S proteasome using Z-LLE-AMC as substrate after 30 mins by fluorescence assay2012Journal of natural products, May-25, Volume: 75, Issue:5
Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasome.
AID402522Cytotoxicity against human U251 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402517Cytotoxicity against human COLO205 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID671272Inhibition of tryptic-like of purified human 20S proteasome using Boc-LRR-AMC as substrate after 30 mins by fluorescence assay2012Journal of natural products, May-25, Volume: 75, Issue:5
Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasome.
AID402514Cytotoxicity against human HOP92 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402528Cytotoxicity against human MDA-MB-231 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
AID402519Cytotoxicity against human HT-29 cells by SRB assay1997Journal of natural products, Feb, Volume: 60, Issue:2
Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's8 (66.67)29.6817
2010's3 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.71 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.28 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.71)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		2.0310amino-acid anion
hydroxyproline
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.		2.05104-hydroxyproline;
L-alpha-amino acid zwitterion		human metabolite;
mouse metabolite;
plant metabolite
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.4620pyrrole;
secondary amine
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		7.0310metal allergen;
nickel group element atom;
platinum group metal atom
bromine
Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.		2.0310diatomic bromine
imidazolidines
[no description available]		2.0310azacycloalkane;
imidazolidines;
saturated organic heteromonocyclic parent
benzyloxycarbonylleucyl-leucyl-leucine aldehyde
benzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor. N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.		2.0710amino aldehyde;
carbamate ester;
tripeptide		proteasome inhibitor
oroidin
oroidin: from marine sponges of the genus Agelas; structure in first source		7.0710pyrroles;
secondary carboxamide		metabolite
epoxomicin
[no description available]		2.0710morpholines;
tripeptide		proteasome inhibitor
dibromophakellin
dibromophakellin: an alpha2B receptor agonist; isolated from Acanthella costata and Pseudoaxinyssa cantharella; structure in first source. (-)-dibromophakellin : An alkaloid isolated from the marine sponge Phakellia flabellata and Acanthella costata. It acts as an alpha2B adrenoceptor agonist.		2.9640alkaloid;
guanidines;
organobromine compound		alpha-adrenergic agonist;
animal metabolite;
marine metabolite
palau'amine
palau'amine: structure in first source		7.0710
debromohymenialdisine
[no description available]		1.9910
ConditionIndicatedRelationship StrengthStudiesTrials