phakellistatin 13: isolated from the marine sponge Phakellia; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 11125657 |
| CHEMBL ID | 510827 |
| CHEBI ID | 181743 |
| MeSH ID | M0450237 |
| Synonym |
|---|
| (6s,9s,15s,18s,21s,24s)-6-benzyl-21-[(1r)-1-hydroxyethyl]-15-(1h-indol-3-ylmethyl)-18-(2-methylpropyl)-1,4,7,13,16,19,22-heptazatricyclo[22.3.0.09,13]heptacosane-2,5,8,14,17,20,23-heptone |
| CHEBI:181743 |
| phakellistatin 13 |
| CHEMBL510827 |
| Q15425278 |
| DTXSID901045610 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The validation results demonstrated that this method was significantly specific, accurate, precise, and was successfully applied in measuring levels of PK13 in rat plasma following intravenous administration of 20, 50, and 100 microg/kg of peptide in rats, respectively, which was suitable for the preclinical pharmacokinetic studies on PK13." | ( Quantitative determination of Phakellistatin 13, a new cyclic heptapeptide, in rat plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study. Fan, G; Lin, H; Wei, H; Wen, J; Wu, Y; Xie, R, 2009) | 0.64 |
| Class | Description |
|---|---|
| oligopeptide | A peptide containing a relatively small number of amino acids. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID334208 | Cytotoxicity against human Bel7404 cells | 2003 | Journal of natural products, Jan, Volume: 66, Issue:1 | Isolation and structure of the cytotoxic cycloheptapeptide phakellistatin 13. |
| AID379925 | Cytotoxicity against human Bel-7402 | 2006 | Journal of natural products, Dec, Volume: 69, Issue:12 | Cyclic heptapeptides from the Jamaican sponge Stylissa caribica. |
| AID334209 | Cytotoxicity against human HL60 cells | 2003 | Journal of natural products, Jan, Volume: 66, Issue:1 | Isolation and structure of the cytotoxic cycloheptapeptide phakellistatin 13. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||