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potassium channel complex

Definition

Target type: cellularcomponent

An ion channel complex through which potassium ions pass. [GOC:mah]

The potassium channel complex is a multi-protein structure embedded in the cell membrane that facilitates the selective passage of potassium ions (K+) across the membrane. It plays a crucial role in a wide range of cellular processes, including nerve impulse transmission, muscle contraction, and maintaining cell volume. The complex typically consists of four subunits, each containing a transmembrane domain responsible for ion permeation and a cytoplasmic domain involved in regulation and interaction with other proteins. These subunits assemble into a tetrameric structure, forming a central pore through which K+ ions can flow. The pore is highly selective for K+ ions, excluding other ions due to specific interactions between the amino acid residues lining the pore and the hydrated K+ ion. This selectivity is essential for maintaining the electrochemical gradients across cell membranes, which are crucial for cellular function. The potassium channel complex can exist in different conformations, transitioning between open, closed, and inactivated states, regulating the flow of K+ ions across the membrane in response to various stimuli. These conformational changes are often triggered by changes in membrane voltage, binding of ligands, or phosphorylation events. The potassium channel complex interacts with a variety of other proteins, including scaffolding proteins, regulatory proteins, and signaling molecules. These interactions contribute to the complex regulation of potassium channel function and its involvement in diverse cellular pathways. The potassium channel complex is a highly dynamic and multifaceted structure that plays a critical role in maintaining cellular homeostasis and facilitating various cellular processes. Understanding the structure and function of the potassium channel complex is essential for comprehending normal cellular function and for developing strategies to treat diseases related to potassium channel dysfunction.'
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Proteins (2)

ProteinDefinitionTaxonomy
Potassium voltage-gated channel subfamily A member 5A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human. []Homo sapiens (human)
Potassium voltage-gated channel subfamily A member 6A voltage-gated potassium channel subunit KCNA6 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P17658]Homo sapiens (human)

Compounds (16)

CompoundDefinitionClassesRoles
N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamidenaphthalenes;
sulfonic acid derivative
5-methoxypsoralen5-methoxypsoralen : A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.

5-Methoxypsoralen: A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.
5-methoxyfurocoumarin;
organic heterotricyclic compound;
psoralens
hepatoprotective agent;
plant metabolite
flecainideflecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).

Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
aromatic ether;
monocarboxylic acid amide;
organofluorine compound;
piperidines
anti-arrhythmia drug
lidocainelidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
benzenes;
monocarboxylic acid amide;
tertiary amino compound
anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic
nifedipineNifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.C-nitro compound;
dihydropyridine;
methyl ester
calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
sertindolesertindole : A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-oxoimidazolidin-1-yl)ethyl group.heteroarylpiperidine;
imidazolidinone;
organochlorine compound;
organofluorine compound;
phenylindole
alpha-adrenergic antagonist;
H1-receptor antagonist;
second generation antipsychotic;
serotonergic antagonist
4'-methoxyflavone4'-methoxyflavone: from seeds of Psoralea corylifolia (Fabaceae); structure in first sourceether;
flavonoids
senicapocsenicapoc: a Gardos channel blocker; structure in first source
quinidinequinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.

Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
cinchona alkaloidalpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker
(2'-(benzyloxycarbonylaminomethyl)biphenyl-2-carboxylic acid 2-(2-pyridyl)ethylamide)biphenyls
acacetin5,7-dihydroxy-4'-methoxyflavone : A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.dihydroxyflavone;
monomethoxyflavone
anticonvulsant;
plant metabolite
clathrodinclathrodin: structure given in first source; isolated from marine sponges of the genus Agelas
oroidinoroidin: from marine sponges of the genus Agelas; structure in first sourcepyrroles;
secondary carboxamide
metabolite
hymenidinhymenidin: serotonergic receptor antagonist from Okinawan marine sponge Hymeniacidon; structure given in first source
a 1899A 1899: a TASK-1 potassium channel blocker; structure in first source
[[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzenemonoterpenoid