oroidin has been researched along with imidazole* in 2 studies
2 other study(ies) available for oroidin and imidazole
| Article | Year |
|---|---|
Metabolomics approach to chemical diversity of the Mediterranean marine sponge Agelas oroides.
The Mediterranean marine sponge Agelas oroides is known to contain a large quantity of oroidin, a deterrent, antifouling and antibiofilm pyrrole-2-aminoimidazole. In contrast with other tropical specimens, the chemical composition of Mediterranean Agelas oroides is surprisingly relatively poor in other related metabolites. In the course of finding novel marine natural products, LC-MS based metabolomics study of the Mediterranean Agelas oroides, however, revealed that next to the major compound oroidin, the sponge contains in fact a great diversity of known pyrrole-imidazole alkaloids in minute amounts. Here, we describe identification of 13 known oroidin class alkaloids along with one new monobromoagelaspongin (24). Five betaines and one amine were also identified from the aqueous fraction. One of those compounds (-)-equinobetaine B (30) was found to be an enantiomer of the known natural product (+)-equinobetaine B. Topics: Agelas; Alkaloids; Animals; Biological Products; Imidazoles; Metabolomics; Porifera; Pyrroles | 2017 |
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
Novel approaches that do not rely upon developing microbicidal compounds are sorely needed to combat multidrug resistant (MDR) bacteria. The potential of marine secondary metabolites to serve as a source of non-traditional anti-bacterial agents is demonstrated by showing that pyrrole-imidazole alkaloids inhibit biofilm formation and suppress antibiotic resistance. Topics: Acinetobacter baumannii; Alkaloids; Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Imidazoles; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Porifera; Pyrroles; Structure-Activity Relationship | 2016 |