Page last updated: 2024-12-11

6-chloropurine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5359277
CHEMBL ID140037
CHEBI ID177625
SCHEMBL ID9081
SCHEMBL ID21121896
MeSH IDM0212312

Synonyms (70)

Synonym
EN300-30395
CHEBI:177625
nsc744
1h-purine, 6-chloro-
purine, 6-chloro-
x 47
6-cp
sk 6048
wln: t56 bm dn fn hnj ig
nsc-744
nsc 744
6-chloro-1h-purine
einecs 201-745-6
6-chlorpurine
ai3-26401
87-42-3
6-chloropurine ,
6-chloro-9h-purine
CLP ,
6-chloropurine, 99%
6-chloropurine, >=99%
STK501251
6-chloropurine, >=95.0% (hplc)
AC-3252
zkbqdfawxltyks-uhfffaoysa-
6-chloro-7h-purine
inchi=1/c5h3cln4/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2h,(h,7,8,9,10)
CHEMBL140037
ES4 ,
AG-670/31548001
AKOS000267571
AKOS005259271
133762-83-1
ccris 3908
6-chloropurin-9-yl
6-chlor-7h-purin
unii-oh8700156w
oh8700156w ,
BP-10522
FT-0601457
PS-3424
AM20110246
AB02899
111055-92-6
6-chloropurine [mi]
S4801
SCHEMBL9081
3KQO
SY004779
mfcd00075825
6-chloro-purine
6-chloropurin
W-104024
STR05267
HY-Y0247
us9138393, 6-chloropurine
us9144538, 6-chloropurine
bdbm181123
J-514884
CS-W008651
F0001-2162
6-chloropurine, crystalline
SCHEMBL21121896
Z295458158
BCP27820
6-chloro-9h-purine;6-chloro-7h-purine
DTXSID00861673
CCG-266258
Q27285654
PD088415
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
purinesA class of imidazopyrimidines that consists of purine and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (13)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
Chain A, Phenylethanolamine N-methyltransferaseHomo sapiens (human)Kd140.00004.6000234.7667690.0000AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID55471Binding affinity to DNA intercalator Acridine orange.2001Journal of medicinal chemistry, Dec-20, Volume: 44, Issue:26
Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2010The Biochemical journal, Oct-01, Volume: 431, Issue:1
Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (49)

TimeframeStudies, This Drug (%)All Drugs %
pre-199017 (34.69)18.7374
1990's4 (8.16)18.2507
2000's12 (24.49)29.6817
2010's16 (32.65)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 34.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index34.23 (24.57)
Research Supply Index3.95 (2.92)
Research Growth Index4.82 (4.65)
Search Engine Demand Index42.45 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (34.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (1.96%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other50 (98.04%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]