Compounds > 4,4'-diaminobenzophenone
Page last updated: 2024-12-06

4,4'-diaminobenzophenone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4,4'-diaminobenzophenone, also known as DABP, is a colorless to pale yellow solid organic compound. It is a versatile intermediate used in the synthesis of various organic compounds, including dyes, pharmaceuticals, and polymers. DABP is commonly synthesized through the reaction of benzophenone with aniline in the presence of a catalyst. It serves as a building block for producing high-performance polymers like polyamides and polyimides, known for their excellent thermal and mechanical properties. DABP is also utilized in the synthesis of photoinitiators, which play a crucial role in curing processes like UV-curing and photopolymerization. The compound's ability to absorb UV light and initiate polymerization reactions has led to its widespread application in printing inks, coatings, and adhesives. Furthermore, DABP has attracted research interest for its potential applications in organic electronics, particularly in the development of organic light-emitting diodes (OLEDs) and organic solar cells.'

4,4'-diaminobenzophenone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID69149
CHEMBL ID79925
SCHEMBL ID62657
MeSH IDM0510022

Synonyms (35)

Synonym
BIDD:GT0665
AC-20506
CHEMBL79925 ,
nsc-6096
611-98-3
methanone, bis(4-aminophenyl)-
nsc6096
bis(4-aminophenyl)methanone
4,4'-diaminobenzophenone
inchi=1/c13h12n2o/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8h,14-15h
4,4'-diaminobenzophenone, 97%
4,4''-diaminobenzophenone
bis-(4-amino-phenyl)-methanone
bdbm50145812
D1561
AKOS003235739
A833091
unii-y4n7tyw77x
nsc 6096
y4n7tyw77x ,
ai3-03716
FT-0601925
SCHEMBL62657
4,4'-diaminobenzophenon
4,4-diaminobenzophenone
bis(4-aminophenyl)methanone #
DTXSID20209997
mfcd00038138
CS-W015006
SY038944
4,4 inverted exclamation mark -diaminobenzophenone
AS-19934
AMY15568
Q27294261
F11775
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Genome polyprotein Kd20.00002.90002.90002.9000AID146231
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (26)

Assay IDTitleYearJournalArticle
AID447005Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 30 mg/kg, ip after 4 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447154Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 100 mg/kg, ip after 2 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446998Anticonvulsant activity in Sprague-Dawley rat assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, po after 1 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447004Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 30 mg/kg, ip after 2 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447001Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 30 mg/kg, ip after 0.25 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446999Anticonvulsant activity in Sprague-Dawley rat assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, po after 2 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID115841Compound was tested for the number of control mice with decreased RBC to that of number of tested mice at 100 mg/kg p.o.; 0/91998Bioorganic & medicinal chemistry letters, Jan-06, Volume: 8, Issue:1
Discovery of FR115092: a novel antinephritic agent.
AID1267460Inhibition of recombinant N-terminal truncated human cytosolic 5'-nucleotidase-2 assessed as inhibition of inosine 5'-monophosphate hydrolysis at 1 mM by rapid green malachite assay2015Journal of medicinal chemistry, Dec-24, Volume: 58, Issue:24
Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.
AID446995Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electric shock-induced seizure at 300 mg/kg, ip after 4 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID146231Dissociation constant for HCV NS3 protease substrate binding site2004Journal of medicinal chemistry, May-06, Volume: 47, Issue:10
Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.
AID447003Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 30 mg/kg, ip after 1 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447151Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 100 mg/kg, ip after 0.25 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447153Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 100 mg/kg, ip after 1 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447000Anticonvulsant activity in Sprague-Dawley rat assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, po after 4 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447155Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 100 mg/kg, ip after 4 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446991Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electric shock-induced seizure at 100 mg/kg, ip after 0.5 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447007Neurotoxicity in Sprague-Dawley rat at 500 mg/kg, po by positional sense and gait and stance test after 1 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446993Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, ip after 4 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446994Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electric shock-induced seizure at 100 mg/kg, ip after 4 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447002Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 30 mg/kg, ip after 0.5 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446997Anticonvulsant activity in Sprague-Dawley rat assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, po after 0.5 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447152Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 100 mg/kg, ip after 0.5 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446990Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, ip after 0.5 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID117036Inhibition of proteinuria in the graft-versus-host disease mice following 100 mg/kg p.o. administration.1998Bioorganic & medicinal chemistry letters, Jan-06, Volume: 8, Issue:1
Discovery of FR115092: a novel antinephritic agent.
AID446996Anticonvulsant activity in Sprague-Dawley rat assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, po after 0.25 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446992Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electric shock-induced seizure at 300 mg/kg, ip after 0.5 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.46

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.46 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.46)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		2.11106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
4-aminobenzoic acid
4-Aminobenzoic Acid: An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.. 4-ammoniobenzoate : A zwitterion obtained by transfer of a proton from the carboxy to the amino group of 4-aminobenzoic acid.. 4-aminobenzoic acid : An aminobenzoic acid in which the amino group is para to the carboxy group.		2.0210aminobenzoic acid;
aromatic amino-acid zwitterion		allergen;
Escherichia coli metabolite;
plant metabolite
5-fluoroindole-2-carboxylic acid
5-fluoroindole-2-carboxylic acid: N-methyl-D-aspartate receptor antagonist		2.0210indolyl carboxylic acid
dapsone
[no description available]		1.9910substituted aniline;
sulfone		anti-inflammatory drug;
antiinfective agent;
antimalarial;
leprostatic drug
2-aminodiphenyl
aminobiphenyl : Any member of the class of biphenyls in which the biphenyl skeleton is substituted by at least one amino group.		2.1110
2-phenylphenol
2-phenylphenol: RN given refers to parent cpd; structure. biphenyl-2-ol : A member of the class of hydroxybiphenyls that is biphenyl substituted by a hydroxy group at position 2. It is generally used as a post-harvest fungicide for citrus fruits.		2.1110hydroxybiphenylsantifungal agrochemical;
environmental food contaminant
benzohydrol
diphenylmethanol : A secondary alcohol that is diphenylmethane which carries a hydroxy group at position 1.		2.1110benzyl alcohols;
secondary alcohol		bacterial xenobiotic metabolite;
human urinary metabolite;
human xenobiotic metabolite;
rat metabolite
4,4'-dihydroxybiphenyl
biphenyl-4,4'-diol : A member of the class of hydroxybiphenyls that is biphenyl with hydroxy groups at positions 4 and 4'.		2.1110hydroxybiphenyls
4,4'-diaminodiphenylmethane
4,4'-diaminodiphenylmethane: RN given refers to parent cpd; structure. 4,4'-diaminodiphenylmethane : An aromatic amine that is diphenylmethane substituted at the 4-position of each benzene ring by an amino group.		2.0510aromatic amineallergen;
carcinogenic agent
di-(4-aminophenyl)ether
di-(4-aminophenyl)ether: structure		2.4220aromatic ether
4,4'-thiodianiline
4,4'-thiodianiline: structure		2.4220substituted aniline
iodoalphionic acid
iodoalphionic acid: RN given refers to parent cpd; do not confuse biliognost with non-print entry term bilignost		2.0210stilbenoid
2,7-dihydroxynaphthalene
[no description available]		2.1110
5-methoxyindole-2-carboxylic acid
5-methoxyindole-2-carboxylic acid: inhibitor of gluconeogenesis; structure. 5-methoxyindole-2-carboxylic acid : An indolecarboxylic acid that is indole-2-carboxylic acid carrying an additional methoxy substituent at position 5.		2.0210aromatic ether;
indolecarboxylic acid		EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitor;
hypoglycemic agent;
plant metabolite
benzylaminopurine
benzylaminopurine: a plant growth regulator. N-benzyladenine : A member of the class of 6-aminopurines that is adenine in which one of the hydrogens of the amino group is replaced by a benzyl group.		2.11106-aminopurinescytokinin;
plant metabolite
perfluorosuccinic acid
perfluorosuccinic acid: inhibitor of gluconeogenesis in rat hepatocytes; RN given refers to parent cpd		2.0210
4(5)-phenylimidazole
4(5)-phenylimidazole: tautomeric cpd; cytochrome P450 14alpha-sterol demethylase, CYP51 antagonist		2.1110
4,4'-diaminobenzanilide
4,4'-diaminobenzanilide: not carcinogenic		2.4220
5-aminoisoquinoline
[no description available]		2.1110
indole-2-carboxylic acid
[no description available]		2.0210indolyl carboxylic acid
parapropamol
[no description available]		2.0210
5-chloroindole-2-carboxylate
5-chloroindole-2-carboxylate: N-methyl-D-aspartate glycine site antagonist		2.0210indolyl carboxylic acid
1-(2-pyridinyl)piperazine
1-(2-pyridinyl)piperazine: metabolite of buspirone & gepirone		2.1110
benzo(b)thiophene-2-carboxylic acid
benzo(b)thiophene-2-carboxylic acid: for prevention of osteoporosis; structure given in first source		2.0210
2-amino-6-chloropurine
6-chloroguanine: an antimalarial that inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase; structure in first source. 6-chloroguanine : An organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6.		2.11102-aminopurines;
organochlorine compound
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.4220
Nephritis
Inflammation of any part of the KIDNEY.		01.9910
Anemia
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.		01.9910
Absence Seizure
[description not available]		02.0510
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		02.0510