4,4'-diaminobenzophenone profile

4,4'-diaminobenzophenone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	69149
CHEMBL ID	79925
SCHEMBL ID	62657
MeSH ID	M0510022

Synonym
BIDD:GT0665
AC-20506
CHEMBL79925 ,
nsc-6096
611-98-3
methanone, bis(4-aminophenyl)-
nsc6096
bis(4-aminophenyl)methanone
4,4'-diaminobenzophenone
inchi=1/c13h12n2o/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8h,14-15h
4,4'-diaminobenzophenone, 97%
4,4''-diaminobenzophenone
bis-(4-amino-phenyl)-methanone
bdbm50145812
D1561
AKOS003235739
A833091
unii-y4n7tyw77x
nsc 6096
y4n7tyw77x ,
ai3-03716
FT-0601925
SCHEMBL62657
4,4'-diaminobenzophenon
4,4-diaminobenzophenone
bis(4-aminophenyl)methanone #
DTXSID20209997
mfcd00038138
CS-W015006
SY038944
4,4 inverted exclamation mark -diaminobenzophenone
AS-19934
AMY15568
Q27294261
F11775

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Genome polyprotein		Kd	20.0000	2.9000	2.9000	2.9000	AID146231
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (26)

Assay ID	Title	Year	Journal	Article
AID447005	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 30 mg/kg, ip after 4 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447154	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 100 mg/kg, ip after 2 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446998	Anticonvulsant activity in Sprague-Dawley rat assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, po after 1 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447004	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 30 mg/kg, ip after 2 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447001	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 30 mg/kg, ip after 0.25 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446999	Anticonvulsant activity in Sprague-Dawley rat assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, po after 2 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID115841	Compound was tested for the number of control mice with decreased RBC to that of number of tested mice at 100 mg/kg p.o.; 0/9	1998	Bioorganic & medicinal chemistry letters, Jan-06, Volume: 8, Issue:1	Discovery of FR115092: a novel antinephritic agent.
AID1267460	Inhibition of recombinant N-terminal truncated human cytosolic 5'-nucleotidase-2 assessed as inhibition of inosine 5'-monophosphate hydrolysis at 1 mM by rapid green malachite assay	2015	Journal of medicinal chemistry, Dec-24, Volume: 58, Issue:24	Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.
AID446995	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electric shock-induced seizure at 300 mg/kg, ip after 4 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID146231	Dissociation constant for HCV NS3 protease substrate binding site	2004	Journal of medicinal chemistry, May-06, Volume: 47, Issue:10	Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.
AID447003	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 30 mg/kg, ip after 1 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447151	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 100 mg/kg, ip after 0.25 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447153	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 100 mg/kg, ip after 1 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447000	Anticonvulsant activity in Sprague-Dawley rat assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, po after 4 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447155	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 100 mg/kg, ip after 4 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446991	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electric shock-induced seizure at 100 mg/kg, ip after 0.5 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447007	Neurotoxicity in Sprague-Dawley rat at 500 mg/kg, po by positional sense and gait and stance test after 1 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446993	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, ip after 4 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446994	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electric shock-induced seizure at 100 mg/kg, ip after 4 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447002	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 30 mg/kg, ip after 0.5 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446997	Anticonvulsant activity in Sprague-Dawley rat assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, po after 0.5 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID447152	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of minimal clonic seizure at 100 mg/kg, ip after 0.5 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446990	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, ip after 0.5 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID117036	Inhibition of proteinuria in the graft-versus-host disease mice following 100 mg/kg p.o. administration.	1998	Bioorganic & medicinal chemistry letters, Jan-06, Volume: 8, Issue:1	Discovery of FR115092: a novel antinephritic agent.
AID446996	Anticonvulsant activity in Sprague-Dawley rat assessed as inhibition of maximal electric shock-induced seizure at 30 mg/kg, po after 0.25 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
AID446992	Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electric shock-induced seizure at 300 mg/kg, ip after 0.5 hrs	2009	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17	In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Description	Relationhip Strength	Studies	Classes	Roles
dapsone	[no description available]	medium	1	substituted aniline; sulfone	anti-inflammatory drug; antiinfective agent; antimalarial; leprostatic drug
di-(4-aminophenyl)ether	[no description available]	medium	2	aromatic ether
4,4'-thiodianiline	[no description available]	medium	2	substituted aniline
4,4'-diaminobenzanilide	[no description available]	medium	2
4-aminobenzoic acid	[no description available]	medium	1	aminobenzoic acid; aromatic amino-acid zwitterion	allergen; Escherichia coli metabolite; plant metabolite
5-fluoroindole-2-carboxylic acid	[no description available]	medium	1	indolyl carboxylic acid
iodoalphionic acid	[no description available]	medium	1	stilbenoid
5-methoxyindole-2-carboxylic acid	[no description available]	medium	1	aromatic ether; indolecarboxylic acid	EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitor; hypoglycemic agent; plant metabolite
perfluorosuccinic acid	[no description available]	medium	1
indole-2-carboxylic acid	[no description available]	medium	1	indolyl carboxylic acid
parapropamol	[no description available]	medium	1
5-chloroindole-2-carboxylate	[no description available]	medium	1	indolyl carboxylic acid
benzo(b)thiophene-2-carboxylic acid	[no description available]	medium	1
4,4'-diaminodiphenylmethane	[no description available]	medium	1	aromatic amine	allergen; carcinogenic agent
adenine	[no description available]	medium	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
2-aminodiphenyl	[no description available]	medium	1
2-phenylphenol	[no description available]	medium	1	hydroxybiphenyls	antifungal agrochemical; environmental food contaminant
benzohydrol	[no description available]	medium	1	benzyl alcohols; secondary alcohol	bacterial xenobiotic metabolite; human urinary metabolite; human xenobiotic metabolite; rat metabolite
4,4'-dihydroxybiphenyl	[no description available]	medium	1	hydroxybiphenyls
2,7-dihydroxynaphthalene	[no description available]	medium	1
benzylaminopurine	[no description available]	medium	1	6-aminopurines	cytokinin; plant metabolite
4(5)-phenylimidazole	[no description available]	medium	1
5-aminoisoquinoline	[no description available]	medium	1
1-(2-pyridinyl)piperazine	[no description available]	medium	1
2-amino-6-chloropurine	[no description available]	medium	1	2-aminopurines; organochlorine compound

Condition	Relationship Strength	Studies
Absence Seizure	low	1
Absence Seizures	low	1
Anemia	low	1
Atonic Absence Seizure	low	1
Atonic Absence Seizures	low	1
Atonic Seizure	low	1
Atonic Seizures	low	1
Clonic Seizure	low	1
Clonic Seizures	low	1
Complex Partial Seizure	low	1
Complex Partial Seizures	low	1
Convulsion	low	1
Convulsion, Non-Epileptic	low	1
Convulsions	low	1
Convulsive Seizure	low	1
Convulsive Seizures	low	1
Disease Models, Animal	low	2
Epileptic Seizure	low	1
Epileptic Seizures	low	1
Generalized Absence Seizure	low	1
Generalized Absence Seizures	low	1
Generalized Tonic-Clonic Seizures	low	1
Jacksonian Seizure	low	1
Myoclonic Seizure	low	1
Myoclonic Seizures	low	1
Nephritis	low	1
Non-Epileptic Seizure	low	1
Non-Epileptic Seizures	low	1
Nonepileptic Seizure	low	1
Nonepileptic Seizures	low	1
Partial Seizure	low	1
Partial Seizures	low	1
Petit Mal Convulsion	low	1
Seizure	low	1
Seizures	low	1
Seizures, Auditory	low	1
Seizures, Clonic	low	1
Seizures, Convulsive	low	1
Seizures, Epileptic	low	1
Seizures, Focal	low	1
Seizures, Generalized	low	1
Seizures, Gustatory	low	1
Seizures, Motor	low	1
Seizures, Olfactory	low	1
Seizures, Sensory	low	1
Seizures, Somatosensory	low	1
Seizures, Tonic	low	1
Seizures, Tonic-Clonic	low	1
Seizures, Vertiginous	low	1
Seizures, Vestibular	low	1
Seizures, Visual	low	1
Single Seizure	low	1
Tonic Clonic Seizure	low	1
Tonic Seizure	low	1
Tonic Seizures	low	1
Tonic-Clonic Seizure	low	1
Tonic-Clonic Seizures	low	1

4,4'-diaminobenzophenone

Description

Cross-References

Synonyms (35)

Protein Targets (1)

Activation Measurements

Bioassays (26)

Research

Studies (5)

Study Types

Research Highlights

Safety/Toxicity (1)

Article	Year
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity. Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue: 17	2009
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

4,4'-diaminobenzophenone

Description

Cross-References

Synonyms (35)

Protein Targets (1)

Activation Measurements

Bioassays (26)

Research

Studies (5)

Study Types

Related Drugs (25)

Related Conditions (57)

Research Highlights

Safety/Toxicity (1)