2'-o-methyluridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2'-O-methyluridine (2'-OMeU) is a modified nucleoside found in RNA. It is formed by methylation of the 2'-hydroxyl group of uridine. 2'-OMeU is a common modification in various RNA species, including messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA). 2'-OMeU has been shown to play a role in RNA stability, translation efficiency, and RNA structure. Its presence can influence the interactions of RNA with proteins and other molecules. 2'-OMeU is often studied in the context of RNA structure and function, and its role in various biological processes. It is also of interest in the development of novel therapeutic agents, as it can be incorporated into synthetic RNA molecules to modulate their properties.'

Cross-References

ID Source	ID
PubMed CID	102212
CHEBI ID	19227
SCHEMBL ID	25866
MeSH ID	M0148258

Synonyms (28)

Synonym
1-((2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1h,3h)-dione
uridine, 2'-o-methyl-
2140-76-3
2'-o-methyluridine ,
1-[(2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione
o(2')-methyluridine
399vzb6tmb ,
unii-399vzb6tmb
AKOS015919383
CHEBI:19227
o2'-methyluridine
2 inverted exclamation marka-o-methyluridine
AKOS015850961
SCHEMBL25866
J-700070
mfcd00056054
2'-o-methyl-uridine
2'-o-methyluridine, aldrichcpr
CS-W012540
DTXSID10943959
4-hydroxy-1-(2-o-methylpentofuranosyl)pyrimidin-2(1h)-one
AS-12177
Q15632791
HY-W011824
EN300-19734319
1-[(2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
BP-58662
PD158289

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
methyluridine	A uridine bearing one or more methyl substituents.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (14)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (7.14)	18.7374
1990's	5 (35.71)	18.2507
2000's	1 (7.14)	29.6817
2010's	7 (50.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	23.51 (24.57)
Research Supply Index	2.71 (2.92)
Research Growth Index	5.63 (4.65)
Search Engine Demand Index	21.17 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (23.51)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
adenine [no description available]	2.17	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
uracil 2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder	2.13	1	pyrimidine nucleobase; pyrimidone	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite
uridine [no description available]	9.04	14	uridines	drug metabolite; fundamental metabolite; human metabolite
cytidine [no description available]	2.93	4	cytidines	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
pseudouridine [no description available]	1.98	1	pseudouridines	fundamental metabolite
osmium Osmium: A very hard, gray, toxic, and nearly infusible metal element, atomic number 76, atomic weight 190.2, symbol Os.	2.17	1	iron group element atom; platinum group metal atom
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	2.57	2	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
5-methylcytidine [no description available]	2.17	1	methylcytidine
2'-o-methyladenosine cordysinin B : A member of the class of adenosines that is adenosine in which the hydroxy group at position 2' is replaced by a methoxy group. It has been isolated from the mycelia of Cordyceps sinensis.	2.57	2	adenosines; ether	fungal metabolite
2'-o-methylcytidine [no description available]	2.93	4	methylcytidine
ribothymidine ribothymidine : A methyluridine having a single methyl substituent at the 5-position on the uracil ring.	2.17	1	methyluridine	antigen; Escherichia coli metabolite; human metabolite
neocarzinostatin chromophore neocarzinostatin chromophore: nonprotein chromophore of neocarzinostatin; antibiotic activity of Neocarzinostatin depends on wholy on chromophore interaction with DNA; Chrom A & Chrom B are separated by HPLC; Chrom C is derived from Chrom A; Chrom D is inactive minor component. neocarzinostatin chromophore : A naphthoate ester obtained by formal condensation of the carboxy group of 2-hydroxy-7-methoxy-5-methyl-1-naphthoic acid with the 5-hydroxy group of (1aS,5R,6R,6aE,9aR)-5-hydroxy-1a-[(4R)-2-oxo-1,3-dioxolan-4-yl]-2,3,8,9-tetradehydro-1a,5,6,9a-tetrahydrocyclopenta[5,6]cyclonona[1,2-b]oxiren-6-yl 2,6-dideoxy-2-(methylamino)-alpha-D-galactopyranoside. The chromophoric part of neocarzinostatin, it is tightly and non-covelently bound to a 113-membered apoprotein, which serves to protect it and release it to the target DNA.	1.99	1	cyclopentacyclononaoxirene; D-galactosaminide; dioxolane; monosaccharide derivative; naphthoate ester	antineoplastic agent
thiouridine Thiouridine: A photoactivable URIDINE analog that is used as an affinity label.. 4-thiouridine : A thiouridine in which the oxygen replaced by sulfur is that at C-4.	2.1	1	nucleoside analogue; thiouridine	affinity label; antimetabolite
zinostatin Zinostatin: An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.	1.99	1
2-amino-6-chloropurine 6-chloroguanine: an antimalarial that inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase; structure in first source. 6-chloroguanine : An organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6.	2.17	1	2-aminopurines; organochlorine compound
ribose ribopyranose : The pyranose form of ribose.	2.44	2	D-ribose; ribopyranose
oligonucleotides [no description available]	2.1	1
anticodon Anticodon: The sequential set of three nucleotides in TRANSFER RNA that interacts with its complement in MESSENGER RNA, the CODON, during translation in the ribosome.	2	1
d-2-o-methylribose [no description available]	2.13	1
guanine [no description available]	2.17	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanosine ribonucleoside : Any nucleoside where the sugar component is D-ribose.	1.98	1	guanosines; purines D-ribonucleoside	fundamental metabolite
2'-o-methylguanosine 2'-O-methylguanosine : Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.	1.98	1	methylguanosine	metabolite
nucleoside q Nucleoside Q: A modified nucleoside which is present in the first position of the anticodon of tRNA-tyrosine, tRNA-histidine, tRNA-asparagine and tRNA-aspartic acid of many organisms. It is believed to play a role in the regulatory function of tRNA. Nucleoside Q can be further modified to nucleoside Q*, which has a mannose or galactose moiety linked to position 4 of its cyclopentenediol moiety.. queuosine : A nucleoside found in tRNA that has an additional cyclopentenyl ring added via an NH group to the methyl group of 7-methyl-7-deazaguanosine. The cyclopentenyl ring may carry other substituents.	2	1	7-deazaguanine ribonucleoside

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