Compounds > 2'-o-methyluridine
Page last updated: 2024-12-07

2'-o-methyluridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2'-O-methyluridine (2'-OMeU) is a modified nucleoside found in RNA. It is formed by methylation of the 2'-hydroxyl group of uridine. 2'-OMeU is a common modification in various RNA species, including messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA). 2'-OMeU has been shown to play a role in RNA stability, translation efficiency, and RNA structure. Its presence can influence the interactions of RNA with proteins and other molecules. 2'-OMeU is often studied in the context of RNA structure and function, and its role in various biological processes. It is also of interest in the development of novel therapeutic agents, as it can be incorporated into synthetic RNA molecules to modulate their properties.'

Cross-References

ID SourceID
PubMed CID102212
CHEBI ID19227
SCHEMBL ID25866
MeSH IDM0148258

Synonyms (28)

Synonym
1-((2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1h,3h)-dione
uridine, 2'-o-methyl-
2140-76-3
2'-o-methyluridine ,
1-[(2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione
o(2')-methyluridine
399vzb6tmb ,
unii-399vzb6tmb
AKOS015919383
CHEBI:19227
o2'-methyluridine
2 inverted exclamation marka-o-methyluridine
AKOS015850961
SCHEMBL25866
J-700070
mfcd00056054
2'-o-methyl-uridine
2'-o-methyluridine, aldrichcpr
CS-W012540
DTXSID10943959
4-hydroxy-1-(2-o-methylpentofuranosyl)pyrimidin-2(1h)-one
AS-12177
Q15632791
HY-W011824
EN300-19734319
1-[(2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
BP-58662
PD158289
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
methyluridineA uridine bearing one or more methyl substituents.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (7.14)18.7374
1990's5 (35.71)18.2507
2000's1 (7.14)29.6817
2010's7 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.51 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index5.63 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.51)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		2.17106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		2.1310pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
uridine
[no description available]		9.04140uridinesdrug metabolite;
fundamental metabolite;
human metabolite
cytidine
[no description available]		2.9340cytidinesEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
pseudouridine
[no description available]		1.9810pseudouridinesfundamental metabolite
osmium
Osmium: A very hard, gray, toxic, and nearly infusible metal element, atomic number 76, atomic weight 190.2, symbol Os.		2.1710iron group element atom;
platinum group metal atom
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		2.5720adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
5-methylcytidine
[no description available]		2.1710methylcytidine
2'-o-methyladenosine
cordysinin B : A member of the class of adenosines that is adenosine in which the hydroxy group at position 2' is replaced by a methoxy group. It has been isolated from the mycelia of Cordyceps sinensis.		2.5720adenosines;
ether		fungal metabolite
2'-o-methylcytidine
[no description available]		2.9340methylcytidine
ribothymidine
ribothymidine : A methyluridine having a single methyl substituent at the 5-position on the uracil ring.		2.1710methyluridineantigen;
Escherichia coli metabolite;
human metabolite
neocarzinostatin chromophore
neocarzinostatin chromophore: nonprotein chromophore of neocarzinostatin; antibiotic activity of Neocarzinostatin depends on wholy on chromophore interaction with DNA; Chrom A & Chrom B are separated by HPLC; Chrom C is derived from Chrom A; Chrom D is inactive minor component. neocarzinostatin chromophore : A naphthoate ester obtained by formal condensation of the carboxy group of 2-hydroxy-7-methoxy-5-methyl-1-naphthoic acid with the 5-hydroxy group of (1aS,5R,6R,6aE,9aR)-5-hydroxy-1a-[(4R)-2-oxo-1,3-dioxolan-4-yl]-2,3,8,9-tetradehydro-1a,5,6,9a-tetrahydrocyclopenta[5,6]cyclonona[1,2-b]oxiren-6-yl 2,6-dideoxy-2-(methylamino)-alpha-D-galactopyranoside. The chromophoric part of neocarzinostatin, it is tightly and non-covelently bound to a 113-membered apoprotein, which serves to protect it and release it to the target DNA.		1.9910cyclopentacyclononaoxirene;
D-galactosaminide;
dioxolane;
monosaccharide derivative;
naphthoate ester		antineoplastic agent
thiouridine
Thiouridine: A photoactivable URIDINE analog that is used as an affinity label.. 4-thiouridine : A thiouridine in which the oxygen replaced by sulfur is that at C-4.		2.110nucleoside analogue;
thiouridine		affinity label;
antimetabolite
zinostatin
Zinostatin: An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.		1.9910
2-amino-6-chloropurine
6-chloroguanine: an antimalarial that inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase; structure in first source. 6-chloroguanine : An organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6.		2.17102-aminopurines;
organochlorine compound
ribose
ribopyranose : The pyranose form of ribose.		2.4420D-ribose;
ribopyranose
oligonucleotides
[no description available]		2.110
anticodon
Anticodon: The sequential set of three nucleotides in TRANSFER RNA that interacts with its complement in MESSENGER RNA, the CODON, during translation in the ribosome.		210
d-2-o-methylribose
[no description available]		2.1310
guanine
[no description available]		2.17102-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
guanosine
ribonucleoside : Any nucleoside where the sugar component is D-ribose.		1.9810guanosines;
purines D-ribonucleoside		fundamental metabolite
2'-o-methylguanosine
2'-O-methylguanosine : Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.		1.9810methylguanosinemetabolite
nucleoside q
Nucleoside Q: A modified nucleoside which is present in the first position of the anticodon of tRNA-tyrosine, tRNA-histidine, tRNA-asparagine and tRNA-aspartic acid of many organisms. It is believed to play a role in the regulatory function of tRNA. Nucleoside Q can be further modified to nucleoside Q*, which has a mannose or galactose moiety linked to position 4 of its cyclopentenediol moiety.. queuosine : A nucleoside found in tRNA that has an additional cyclopentenyl ring added via an NH group to the methyl group of 7-methyl-7-deazaguanosine. The cyclopentenyl ring may carry other substituents.		2107-deazaguanine ribonucleoside
ConditionIndicatedRelationship StrengthStudiesTrials