Page last updated: 2024-10-24

transmembrane receptor protein tyrosine phosphatase activity

Definition

Target type: molecularfunction

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]

Transmembrane receptor protein tyrosine phosphatase activity is a complex enzymatic process involving transmembrane receptors that possess intrinsic tyrosine phosphatase activity. These receptors play crucial roles in cellular signaling pathways, mediating a wide range of biological functions. They function by removing phosphate groups (dephosphorylation) from tyrosine residues on target proteins, thereby regulating protein activity and downstream signaling events. The process typically involves the following steps: 1. Ligand binding: A specific ligand, such as a growth factor or cytokine, binds to the extracellular domain of the transmembrane receptor. This binding event triggers a conformational change in the receptor, activating its tyrosine phosphatase activity. 2. Autophosphorylation: Upon activation, the receptor undergoes autophosphorylation, meaning that it adds a phosphate group to one or more of its own tyrosine residues. This autophosphorylation event serves as a key step in initiating the signaling cascade. 3. Substrate recruitment and dephosphorylation: The phosphorylated tyrosine residues on the activated receptor serve as docking sites for other signaling proteins, including adaptor proteins and effector enzymes. These proteins bind to the receptor via their SH2 domains, which specifically recognize phosphorylated tyrosine residues. Once bound, the receptor's tyrosine phosphatase activity can dephosphorylate tyrosine residues on its associated substrates. This dephosphorylation event can either activate or inhibit the activity of the substrate protein, depending on the specific signaling pathway. 4. Signal transduction: The dephosphorylation of substrate proteins by the transmembrane receptor protein tyrosine phosphatase triggers downstream signaling events, ultimately leading to changes in cellular behavior, such as cell growth, differentiation, or apoptosis. Examples of transmembrane receptor protein tyrosine phosphatases include receptor protein tyrosine phosphatase alpha (RPTPĪ±), receptor protein tyrosine phosphatase beta (RPTPĪ²), and leukocyte common antigen-related protein (LAR). These phosphatases are involved in various signaling pathways related to cell adhesion, migration, and immune responses.'
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Proteins (8)

ProteinDefinitionTaxonomy
Tyrosine-protein phosphatase non-receptor type 6A tyrosine-protein phosphatase non-receptor type 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29350]Homo sapiens (human)
Receptor-type tyrosine-protein phosphatase muA receptor-type tyrosine-protein phosphatase mu that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28827]Homo sapiens (human)
Receptor-type tyrosine-protein phosphatase gammaA receptor-type tyrosine-protein phosphatase gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23470]Homo sapiens (human)
Receptor-type tyrosine-protein phosphatase epsilonA receptor-type tyrosine-protein phosphatase epsilon that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23469]Homo sapiens (human)
Receptor-type tyrosine-protein phosphatase betaA receptor-type tyrosine-protein phosphatase beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23467]Homo sapiens (human)
Receptor-type tyrosine-protein phosphatase alphaA receptor-type tyrosine-protein phosphatase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18433]Homo sapiens (human)
Receptor-type tyrosine-protein phosphatase FA receptor-type tyrosine-protein phosphatase F that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10586]Homo sapiens (human)
Receptor-type tyrosine-protein phosphatase CA receptor-type tyrosine-protein phosphatase C that is encoded in the genome of human. [PRO:CNA, UniProtKB:P08575]Homo sapiens (human)

Compounds (43)

CompoundDefinitionClassesRoles
4-hydroxyphenylglyoxylic acid4-hydroxyphenylglyoxylate : Conjugate base of 4-hydroxyphenylglyoxylic acid.

4-hydroxyphenylglyoxylic acid: RN given refers to parent cpd
phenols
4-nitrophenylphosphate4-nitrophenyl phosphate : An aryl phosphate resulting from the mono-esterification of phosphoric acid with 4-nitrophenol.

nitrophenylphosphate: RN given refers to mono(4-nitrophenyl) ester of phosphoric acid
aryl phosphatemouse metabolite
pyridoxal phosphatepyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.

Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate
coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
5-iodo-2-(oxaloamino)benzoic acidorganoiodine compound
9,10-phenanthrenequinone9,10-phenanthrenequinone: structurephenanthrenes
glycyrrhetinic acidcyclic terpene ketone;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid
immunomodulator;
plant metabolite
oleanolic acidhydroxy monocarboxylic acid;
pentacyclic triterpenoid
plant metabolite
1,2-naphthoquinone1,2-naphthoquinone : The parent structure of the family of 1,2-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 2 of the naphthalene ring. It is a metabolite of naphthalene and is found in diesel exhaust particles.

naphthalene-1,2-dione: structure given in first source
1,2-naphthoquinonesaryl hydrocarbon receptor agonist;
carcinogenic agent
3,5-dibromotyrosine3,5-dibromotyrosine: used to synthesize various secondary metabolites from marine spongesmonocarboxylic acid
(4-tert-Butyl-phenoxy)-acetic acidmonocarboxylic acid
vanadatesvanadate(3-) : A vanadium oxoanion that is a trianion with formula VO4 in which the vanadium is in the +5 oxidation state and is attached to four oxygen atoms.

Vanadates: Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects.
trivalent inorganic anion;
vanadium oxoanion
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor
ursolic acidhydroxy monocarboxylic acid;
pentacyclic triterpenoid
geroprotector;
plant metabolite
methyl fluorone blackmethyl fluorone black: structure
maslinic acid(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid: from Luehea divaricata and Agrimonia eupatoriadihydroxy monocarboxylic acid;
pentacyclic triterpenoid
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
plant metabolite
nsc-87877NSC-87877: potent Shp2 (nonreceptor protein tyrosine phosphatase) inhibitor; structure in first source
2-(4-hydroxyphenyl)-5,6,7,8-tetrahydroxy-4H-1-benzopyran-4-one2-(4-hydroxyphenyl)-5,6,7,8-tetrahydroxy-4H-1-benzopyran-4-one : A pentahydroxyflavone that is flavone substituted by hydroxy groups at positions 5, 6, 7, 8, and 4' respectively.pentahydroxyflavone
1-amino-2-phenylethylphosphonic acid1-amino-2-phenylethylphosphonic acid: RN given refers to cpd without isomeric designation: structure given in first source
tanshinonetanshinone: from root of Salvia miltiorrhiza Bunge; RN given refers to tanshinone I; cardioprotective agent and neuroprotective agentabietane diterpenoidanticoronaviral agent
celastrolmonocarboxylic acid;
pentacyclic triterpenoid
anti-inflammatory drug;
antineoplastic agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Hsp90 inhibitor;
metabolite
cryptotanshinonecryptotanshinone: from Salvia miltiorrhizaabietane diterpenoidanticoronaviral agent
tanshinone ii atashinone IIA: a cardiovascular agent with antineoplastic activity; isolated from Salvia miltiorrhiza; structure in first sourceabietane diterpenoid
biotinvitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.biotins;
vitamin B7
coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
1-Anilino-9,10-dioxo-2-anthroic acidanthracenes
4-[(1,3-dimethyl-2,6-dioxo-7H-purin-8-yl)methylamino]benzoic acidoxopurine
nsc-89199estramustine phosphate : A steroid phosphate which is the 17-O-phospho derivative of estramustine.carbamate ester;
organochlorine compound;
steroid phosphate
3-(3-pyridinyl)propanoic acidpyridines
2-(oxaloamino)benzoic acid(oxaloamino)benzoic acid
moronic acidmoronic acid : A pentacyclic triterpenoid that is olean-18-ene substituted at position 3 by an oxo group and position 28 by a carboxy group.

moronic acid: from root bark extract of Ozoroa mucronata; RN & N1 from 9th CI
pentacyclic triterpenoidanti-HIV agent;
anti-HSV-1 agent;
metabolite
morolic acidmorolic acid: from Pistacia terebinthus galls; structure in first source
cefsulodincefsulodin : A pyridinium-substituted semi-synthetic, broad-spectrum, cephalosporin antibiotic.

Cefsulodin: A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients.
cephalosporin;
organosulfonic acid;
primary carboxamide
antibacterial drug
nq301NQ301: structure in first source
nsc 117199
illudalic acidilludalic acid: isolated from Clitocybe illudens; structure in first source
myricitrinmyricitrin : A glycosyloxyflavone that consists of myricetin attached to a alpha-L-rhamnopyranosyl residue at position 3 via a glycosidic linkage. Isolated from Myrica cerifera, it exhibits anti-allergic activity.

myricitrin: isolated from root bark of Myrica cerifera L.; structure
alpha-L-rhamnoside;
glycosyloxyflavone;
monosaccharide derivative;
pentahydroxyflavone
anti-allergic agent;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
plant metabolite
2-amino-6-chloropurine6-chloroguanine : An organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6.

6-chloroguanine: an antimalarial that inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase; structure in first source
2-aminopurines;
organochlorine compound
5,6-dichloro-1H-imidazo[4,5-b]pyrazine-2-carboxylic acidimidazopyrazine
corosolic acidtriterpenoidmetabolite
Dihydrotanshinone Idihydrotanshinone I: extracted from Radix Salviaeabietane diterpenoidanticoronaviral agent
3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid: an SHP2 inhibitor; structure in first source
akb-9778AKB-9778: an inhibitor of vascular endothelial-protein tyrosine phosphatase
variabilinvariabilin: an RGD-containing antagonist of glycoprotein IIb-IIIa from the hard tick, Dermacentor variabilis; amino acid sequence given in first source
streptovaricin cstreptovaricin C: structure given in first source
galloflavingalloflavin: structure in first source