Page last updated: 2024-10-24

chondroitin sulfate proteoglycan binding

Definition

Target type: molecularfunction

Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit. [GOC:kmv, ISBN:0198506732]

Chondroitin sulfate proteoglycans (CSPGs) are large, complex molecules that play a crucial role in the extracellular matrix (ECM) of various tissues, particularly cartilage, tendons, and ligaments. They are composed of a core protein to which multiple chondroitin sulfate glycosaminoglycan chains are attached. The molecular function of CSPG binding involves interactions between specific protein domains and the glycosaminoglycan chains of CSPGs. These interactions are crucial for a variety of biological processes, including:

**1. Structural Support and Tissue Integrity:**
- CSPGs contribute significantly to the tensile strength and resilience of tissues. They form a mesh-like network that provides structural support and helps maintain the shape and integrity of the ECM.

**2. Cell Adhesion and Signaling:**
- The glycosaminoglycan chains of CSPGs act as binding sites for various cell surface receptors, including integrins and growth factor receptors. These interactions are essential for cell adhesion, migration, and signaling processes.

**3. Regulation of Growth Factor Activity:**
- CSPGs can sequester growth factors in the ECM, regulating their availability and activity. This mechanism plays a critical role in tissue development, repair, and regeneration.

**4. Modulation of Cell Differentiation:**
- CSPGs can influence the differentiation of various cell types, including chondrocytes, fibroblasts, and stem cells. They can promote or inhibit cell differentiation depending on the specific CSPG type and the cellular context.

**5. Lubrication and Shock Absorption:**
- In cartilage, CSPGs contribute to the lubrication and shock-absorbing properties of the joint. The glycosaminoglycan chains act as a sponge, attracting water and creating a hydrated gel that cushions and protects the joint.

**6. Regulation of Water Content:**
- CSPGs play a vital role in maintaining the water content of the ECM. The glycosaminoglycan chains attract water, creating a hydrated gel that provides turgor pressure and contributes to the tissue's mechanical properties.

**7. Barrier Function:**
- In the brain, CSPGs act as a barrier to cell migration and axonal regeneration after injury. This function is crucial for protecting the nervous system and maintaining its integrity.

The specific molecular interactions between CSPGs and their binding partners are complex and highly regulated. Understanding these interactions is essential for developing new therapies for diseases that affect the ECM, such as arthritis, osteoarthritis, and cancer. CSPGs represent a promising target for drug development, with the potential to modulate cell function, tissue regeneration, and disease progression.'
"

Proteins (1)

ProteinDefinitionTaxonomy
Receptor-type tyrosine-protein phosphatase FA receptor-type tyrosine-protein phosphatase F that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10586]Homo sapiens (human)

Compounds (15)

CompoundDefinitionClassesRoles
4-hydroxyphenylglyoxylic acid4-hydroxyphenylglyoxylate : Conjugate base of 4-hydroxyphenylglyoxylic acid.

4-hydroxyphenylglyoxylic acid: RN given refers to parent cpd
phenols
5-iodo-2-(oxaloamino)benzoic acidorganoiodine compound
oleanolic acidhydroxy monocarboxylic acid;
pentacyclic triterpenoid
plant metabolite
vanadatesvanadate(3-) : A vanadium oxoanion that is a trianion with formula VO4 in which the vanadium is in the +5 oxidation state and is attached to four oxygen atoms.

Vanadates: Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects.
trivalent inorganic anion;
vanadium oxoanion
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor
ursolic acidhydroxy monocarboxylic acid;
pentacyclic triterpenoid
geroprotector;
plant metabolite
maslinic acid(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid: from Luehea divaricata and Agrimonia eupatoriadihydroxy monocarboxylic acid;
pentacyclic triterpenoid
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
plant metabolite
cryptotanshinonecryptotanshinone: from Salvia miltiorrhizaabietane diterpenoidanticoronaviral agent
2-(oxaloamino)benzoic acid(oxaloamino)benzoic acid
moronic acidmoronic acid : A pentacyclic triterpenoid that is olean-18-ene substituted at position 3 by an oxo group and position 28 by a carboxy group.

moronic acid: from root bark extract of Ozoroa mucronata; RN & N1 from 9th CI
pentacyclic triterpenoidanti-HIV agent;
anti-HSV-1 agent;
metabolite
morolic acidmorolic acid: from Pistacia terebinthus galls; structure in first source
cefsulodincefsulodin : A pyridinium-substituted semi-synthetic, broad-spectrum, cephalosporin antibiotic.

Cefsulodin: A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients.
cephalosporin;
organosulfonic acid;
primary carboxamide
antibacterial drug
illudalic acidilludalic acid: isolated from Clitocybe illudens; structure in first source
2-amino-6-chloropurine6-chloroguanine : An organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6.

6-chloroguanine: an antimalarial that inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase; structure in first source
2-aminopurines;
organochlorine compound
corosolic acidtriterpenoidmetabolite
3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid: an SHP2 inhibitor; structure in first source