brilliant crocein

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Brilliant crocein is a synthetic azo dye that is a bright orange-red color. It is used in a variety of applications, including food coloring, textile dyeing, and as a biological stain. It is synthesized through a multi-step process that involves diazotization of an aromatic amine followed by coupling with a naphthol derivative. Brilliant crocein has been shown to have some biological activity, including cytotoxic effects on cancer cells. It has also been studied for its potential use in biosensing applications. Due to its properties and its potential for use in various fields, Brilliant crocein remains a subject of ongoing research.'

brilliant crocein: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

woodstain scarlet : An organic sodium salt that is the disodium salt of 7-hydroxy-8-{[4-(phenyldiazenyl)phenyl]diazenyl}naphthalene-1,3-disulfonic acid. Occasionally used for the demonstration of muscle fibres in conjunction with, or as a replacement for, acid fuchsin. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	21519
CHEBI ID	87189
SCHEMBL ID	340440
SCHEMBL ID	185277
MeSH ID	M0362837

Synonyms (45)

Synonym
nsc-47724
c.i. 27290
nsc-7832
crocein scarlet moo
woodstain scarlet
c.i. acid red 73, disodium salt
brilliant croceine moo
c.i. acid red 73
5413-75-2
acid red 73
crocein scarlet 3b
ci 27290
unii-5pla82fv3c
nsc 7832
einecs 226-502-1
7-hydroxy-8-((4-(phenylazo)phenyl)azo)-1,3-naphthalenedisulfonic acid, disodium salt
brilliant crocein
nsc 47724
sodium 6-hydroxy-5-(4-phenylazophenylazo)naphthalene-2,4-disulphonate
5pla82fv3c ,
brilliant scarlet r (van)
1,3-naphthalenedisulfonic acid, 7-hydroxy-8-((4-(phenylazo)phenyl)azo)-, disodium salt
1,3-naphthalenedisulfonic acid, 7-hydroxy-8-(2-(4-(2-phenyldiazenyl)phenyl)diazenyl)-, sodium salt (1:2)
FT-0621856
AKOS015916438
acid red 73 [inci]
solvent red 69
ci 27290 [inci]
SCHEMBL340440
SCHEMBL185277
4-fluoro-3-methylphenethylalcohol
AKOS024375389
disodium 7-hydroxy-8-{[4-(phenyldiazenyl)phenyl]diazenyl}naphthalene-1,3-disulfonate
CHEBI:87189
brilliant crocein moo
mfcd00003907
DTXSID1041712
acid red 73, analytical standard
AKOS030228515
brilliantcroceine
sodium 7-hydroxy-8-((e)-(4-((e)-phenyldiazenyl)phenyl)diazenyl)naphthalene-1,3-disulfonate
Q27262704
1,3-naphthalenedisulfonic acid, 7-hydroxy-8-[2-[4-(2-phenyldiazenyl)phenyl]diazenyl]-, sodium salt (1:2)
D89261
disodium;7-hydroxy-8-[(4-phenyldiazenylphenyl)diazenyl]naphthalene-1,3-disulfonate

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" Effective operational parameters including pH and coagulant and photocatalyst dosage were studied in synthetic wastewater and then the process was applied for real wastewater."	( Enhanced coagulation-photocatalytic treatment of Acid red 73 dye and real textile wastewater using UVA/synthesized MgO nanoparticles. Abtahi, M; Ahmadi, M; Alah Jafarzadeh Haghighifard, N; Barzegar, G; Darvishi Cheshmeh Soltani, R; Jorfi, S; Saeedi, R; Takdastan, A, 2016)	0.43

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
histological dye	A dye used in microscopic or electron microscopic examination of cells and tissues to give contrast and to highlight particular features of interest, such as nuclei and cytoplasm.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

Class	Description
organic sodium salt
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (30.00)	29.6817
2010's	6 (60.00)	24.3611
2020's	1 (10.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	20.20 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	4.96 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (20.20)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (10.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (90.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
piperazine [no description available]	2.03	1	azacycloalkane; piperazines; saturated organic heteromonocyclic parent	anthelminthic drug
rhodamine b rhodamine B: RN & N1 from 9th CI Form Index; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7973; TETRAETHYLRHODAMINE was see RHODAMINES 1975-93; use RHODAMINES to search TETRAETHYLRHODAMINE 1975-93. rhodamine B : An organic chloride salt having N-[9-(2-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium as the counterion. An amphoteric dye commonly used as a fluorochrome.	2.49	2	organic chloride salt; xanthene dye	fluorescent probe; fluorochrome; histological dye
o-aminoazotoluene o-Aminoazotoluene: An azo dye with carcinogenic properties.	2	1
4-phenylenediamine 4-phenylenediamine: agent hair dye responsible for contact dermatitis; RN given refers to parent cpd. 1,4-phenylenediamine : A phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus.	2	1	phenylenediamine	allergen; dye; hapten; reagent
ditiocarb Ditiocarb: A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.. diethyldithiocarbamic acid : A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.	2.03	1	dithiocarbamic acids	chelator; copper chelator
carmine Carmine: Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.	2.21	1
azo rubin s azo rubin S: RN given refers to parent cpd; structure	2.21	1
red 2g red 2G: RN given refers to di-Na salt. azophloxine : An organic sodium salt that is the disodium salt of 5-acetamido-4-hydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid.	2.03	1	organic sodium salt	histological dye
cobalt Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.	2.05	1	cobalt group element atom; metal allergen	micronutrient
tartrazine Tartrazine: An anionic, hydrophilic azo dye with an orange-yellow color used in fabrics, foods and cosmetics, and as a biological stain.. tartrazine : An organic sodium salt which is the trisodium salt of tartrazine acid. A synthetic lemon yellow azo dye used as a food colouring.	2.21	1
lignin Lignin: The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed). lignin : A polyphenylpropanoid derived from three monolignol monomers: trans-p-coumaryl alcohol, coniferol and trans-sinapyl alcohol. There is extensive cross-linking and no defined primary structure.	2.31	1
ponceau s Ponceau S : An organic sodium salt that is the tetrasodium salt of 3-hydroxy-4-({2-sulfo-4-[(4-sulfophenyl)diazenyl]phenyl}diazenyl)naphthalene-2,7-disulfonic acid.	2.11	1	organic sodium salt; organosulfonate salt	fluorochrome; histological dye
dimethyldithiocarbamate Dimethyldithiocarbamate: A chemical that acts as a dopamine beta-hydroxylase inhibitor. Its salts are agricultural fungicides. It is inferior to diethyldithiocarbamate as a chelating agent.. dimethyldithiocarbamate : A member of the class of dithiocarbamate anions resulting from the removal of the proton from the dithiocarbamic acid moiety of dimethyldithiocarbamic acid. The major species at pH 7.3.	2.03	1	dithiocarbamate anions
chitosan [no description available]	2.47	2
2-naphthol orange 2-naphthol orange: structure; see also record for C.I. Solvent Orange 2	2.21	1

Condition	Relationship Strength	Studies
Black Fever [description not available]	2.11	1
Leishmaniasis, Visceral A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.	2.11	1
Allergic Contact Dermatitis [description not available]	2	1
Hypomelanosis [description not available]	2	1
Leg Dermatoses A nonspecific term used to denote any cutaneous lesion or group of lesions, or eruptions of any type on the leg. (From Stedman, 25th ed)	2	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2	1
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	2	1
Hypopigmentation A condition caused by a deficiency or a loss of melanin pigmentation in the epidermis, also known as hypomelanosis. Hypopigmentation can be localized or generalized, and may result from genetic defects, trauma, inflammation, or infections.	2	1

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