Page last updated: 2024-09-27

Coma, Post-Concussive

Prolonged unconsciousness from which the individual cannot be aroused, associated with traumatic injuries to the BRAIN. This may be defined as unconsciousness persisting for 6 hours or longer. Coma results from injury to both cerebral hemispheres or the RETICULAR FORMATION of the BRAIN STEM. Contributing mechanisms include DIFFUSE AXONAL INJURY and BRAIN EDEMA. (From J Neurotrauma 1997 Oct;14(10):699-713)

Synonyms(7)

Synonym
Coma, Post-Traumatic
Coma, Post-Head Injury
Post-Head Injury Coma
Coma, Post-Concussive
Coma, Post-Trauma
Coma, Post-Traumatic, Prolonged
Coma, Traumatic

Research

Studies (15)

TimeframeStudies, This Condition (%)All Conditions %
pre-19904 (26.67)23.3326
1990's0 (0.00)12.5806
2000's5 (33.33)18.1394
2010's6 (40.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low10
amantadine0medium51
glyphosate0low10
papaverine0low10
procaine0low10
zolpidem0low10
dextroamphetamine0low10
levodopa0low10
glycerylphosphorylcholine0low10
bromocriptine0low10
fluorodeoxyglucose f180low10
thiourea0low10
morphine0low10
technetium tc 99m exametazime0low10
ro13-99040low10

Protein Targets (325)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
acetylcholinesterase2002
thioredoxin reductase5005
RAR-related orphan receptor gamma3003
NFKB1 protein, partial2002
GLI family zinc finger 33003
AR protein5005
signal transducer and activator of transcription 6, interleukin-4 induced1001
thyroid stimulating hormone receptor4004
regulator of G-protein signaling 42002
EWS/FLI fusion protein3003
estrogen nuclear receptor alpha5005
putative alpha-glucosidase1001
euchromatic histone-lysine N-methyltransferase 25005
thyroid hormone receptor beta isoform 22002
heat shock protein beta-11001
peripheral myelin protein 225005
histone acetyltransferase KAT2A isoform 12002
lamin isoform A-delta103003
Solute carrier family 22 member 20102
Solute carrier family 22 member 1 0102
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Matrix protein 20112
Matrix protein 20123
Glutamate receptor ionotropic, NMDA 1 0102
Spike glycoprotein1001
Glutamate receptor ionotropic, NMDA 2A 0102
Glutamate receptor ionotropic, NMDA 2B0102
Glutamate receptor ionotropic, NMDA 2C0102
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0102
Solute carrier family 22 member 10101
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0102
Multidrug and toxin extrusion protein 10101
Solute carrier family 22 member 20101
Glutamate receptor ionotropic, NMDA 3A0102
ATP-dependent phosphofructokinase3003
Atrial natriuretic peptide receptor 10011
Atrial natriuretic peptide receptor 1 0011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Genome polyprotein 0112
dopamine D1 receptor2002
ATAD5 protein, partial1001
Fumarate hydratase2002
GLS protein3003
TDP1 protein3003
cytochrome P450 family 3 subfamily A polypeptide 43003
glucocorticoid receptor [Homo sapiens]3003
pregnane X nuclear receptor2002
G1001
polyprotein2002
peroxisome proliferator activated receptor gamma1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
D(1A) dopamine receptor1001
vitamin D3 receptor isoform VDRA1001
chromobox protein homolog 13003
serine/threonine-protein kinase mTOR isoform 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
5-hydroxytryptamine receptor 40202
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 1001
Cellular tumor antigen p531001
ATP-dependent translocase ABCB10202
ATP-dependent translocase ABCB10202
Beta-1 adrenergic receptor0202
Cytochrome P450 3A40213
5-hydroxytryptamine receptor 1A0101
Alpha-2A adrenergic receptor0213
D(2) dopamine receptor0213
Androgen receptor0202
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
D0101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0314
Alpha-2B adrenergic receptor0101
ATP-dependent translocase ABCB10202
D(1A) dopamine receptor0202
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0202
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 2A0213
5-hydroxytryptamine receptor 2C0213
5-hydroxytryptamine receptor 1B0213
D(4) dopamine receptor0101
D(3) dopamine receptor0202
Alpha-synuclein0101
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 60202
D(2) dopamine receptor0112
Inositol hexakisphosphate kinase 11001
ATPase family AAA domain-containing protein 52002
Ataxin-22002
cytochrome P450 2C9, partial1001
5-hydroxytryptamine receptor 2C0011
Phenylethanolamine N-methyltransferase0101
5-hydroxytryptamine receptor 2A0112
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A0101
Sodium-dependent noradrenaline transporter 0213
Sodium-dependent dopamine transporter0022
Amine oxidase [flavin-containing] B0101
5-hydroxytryptamine receptor 1D0011
5-hydroxytryptamine receptor 1F0011
5-hydroxytryptamine receptor 2B0011
5-hydroxytryptamine receptor 60011
Sodium-dependent serotonin transporter0213
Sodium-dependent serotonin transporter0112
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
Amine oxidase [flavin-containing] B0101
Sodium-dependent dopamine transporter 0213
5-hydroxytryptamine receptor 4 0011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
5-hydroxytryptamine receptor 3B0011
Sigma non-opioid intracellular receptor 10011
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Glutamine synthetase 0101
Cytochrome P450 71B10102
Glutamine synthetase 0101
2-dehydro-3-deoxyphosphooctonate aldolase0101
estrogen receptor 2 (ER beta)1001
retinoic acid nuclear receptor alpha variant 12002
estrogen-related nuclear receptor alpha3003
cytochrome P450 2D62002
thyroid stimulating hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
cellular tumor antigen p53 isoform a1001
Integrin beta-31001
Integrin alpha-IIb1001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Luciferase2002
15-lipoxygenase, partial2002
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
phosphopantetheinyl transferase2002
apical membrane antigen 1, AMA11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
arylsulfatase A1001
pyruvate kinase1001
Bloom syndrome protein isoform 11001
hexokinase-4 isoform 12002
atrial natriuretic peptide receptor 1 precursor2002
glucokinase regulatory protein2002
importin subunit beta-1 isoform 11001
flap endonuclease 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
snurportin-11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
geminin1001
DNA polymerase kappa isoform 12002
M-phase phosphoprotein 81001
muscarinic acetylcholine receptor M13003
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Polyphenol oxidase 20001
Carbonic anhydrase 120001
Bile salt export pump0404
Epidermal growth factor receptor0101
Carbonic anhydrase 10001
Carbonic anhydrase 20001
Plasma kallikrein0001
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Carbonic anhydrase 30001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Tyrosinase0101
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Adenosine receptor A10001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Solute carrier family 15 member 10101
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Canalicular multispecific organic anion transporter 10202
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
phosphoglycerate kinase1001
Opioid receptor, delta 1b 0101
Acetylcholinesterase0101
Opioid receptor homologue0101
Acyl-CoA desaturase 10101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M20101
Translocator protein0112
Histidine decarboxylase0011
Proteinase-activated receptor 10112
Delta-type opioid receptor0102
Delta-type opioid receptor0214
Kappa-type opioid receptor0214
Mu-type opioid receptor0216
Kappa-type opioid receptor0214
Mu-type opioid receptor0214
UDP-glucuronosyltransferase 1A30001
Delta-type opioid receptor0214
Kappa-type opioid receptor0202
Kappa-type opioid receptor0214
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Potassium voltage-gated channel subfamily H member 20202
Beta-2 adrenergic receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10101
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
glp-1 receptor, partial1001
PPM1D protein1001
Thrombopoietin1001
aldehyde dehydrogenase 1 family, member A11001
cytochrome P450 2D6 isoform 12002
polyunsaturated fatty acid lipoxygenase ALOX121001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
mitogen-activated protein kinase 11001
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
nuclear receptor ROR-gamma isoform 11001
survival motor neuron protein isoform d1001
cytochrome P450 3A4 isoform 12002
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Gamma-aminobutyric acid receptor subunit pi2204
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Gamma-aminobutyric acid receptor subunit beta-12204
Vascular endothelial growth factor receptor 1 0101
Gamma-aminobutyric acid receptor subunit delta2204
Gamma-aminobutyric acid receptor subunit gamma-22204
Gamma-aminobutyric acid receptor subunit alpha-52204
Gamma-aminobutyric acid receptor subunit alpha-32204
Acetylcholinesterase0101
Gamma-aminobutyric acid receptor subunit gamma-12204
Gamma-aminobutyric acid receptor subunit alpha-22204
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit alpha-42204
Gamma-aminobutyric acid receptor subunit gamma-32204
Gamma-aminobutyric acid receptor subunit alpha-62204
Cytochrome P450 2C190101
Serine hydroxymethyltransferase, mitochondrial0101
Vascular endothelial growth factor receptor 30101
Vascular endothelial growth factor receptor 20101
Histamine H2 receptor1001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Gamma-aminobutyric acid receptor subunit alpha-12204
Gamma-aminobutyric acid receptor subunit beta-32204
Gamma-aminobutyric acid receptor subunit beta-22204
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 11001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0202
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0202
GABA theta subunit2204
CREB-binding protein1001
Gamma-aminobutyric acid receptor subunit epsilon2204
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 0202
Phosphodiesterase 0101
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0102
isocitrate dehydrogenase 1, partial1001
aryl hydrocarbon receptor2002
serine-protein kinase ATM isoform a1001
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
Urease0203
Urease subunit alpha0101
Urease subunit alpha0101
Nuclear receptor ROR-gamma1001
Urease subunit beta0101
Urease subunit beta 0101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
nuclear receptor subfamily 1, group I, member 31001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Albumin0011
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Gamma-aminobutyric acid receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-70101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sphingosine-1-phosphate lyase 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]