amantadine has been researched along with Coma, Post-Concussive in 5 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meyer, MJ | 1 |
| Megyesi, J | 1 |
| Meythaler, J | 1 |
| Murie-Fernandez, M | 1 |
| Aubut, JA | 1 |
| Foley, N | 1 |
| Salter, K | 1 |
| Bayley, M | 1 |
| Marshall, S | 1 |
| Teasell, R | 1 |
| Giacino, JT | 1 |
| Whyte, J | 1 |
| Bagiella, E | 1 |
| Kalmar, K | 1 |
| Childs, N | 1 |
| Khademi, A | 1 |
| Eifert, B | 1 |
| Long, D | 1 |
| Katz, DI | 1 |
| Cho, S | 1 |
| Yablon, SA | 1 |
| Luther, M | 1 |
| Hammond, FM | 1 |
| Nordenbo, A | 1 |
| Novak, P | 1 |
| Mercer, W | 1 |
| Maurer-Karattup, P | 1 |
| Sherer, M | 1 |
| Mukherjee, D | 1 |
| Patil, CG | 1 |
| Palestrant, D | 1 |
| Dlouhy, BJ | 1 |
| Rao, RC | 1 |
| Hughes, S | 1 |
| Colantonio, A | 1 |
| Santaguida, PL | 1 |
| Paton, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of Sensory Stimulation for Person in a Coma or Persistent Vegetative State After Traumatic Brain Injury[NCT02629588] | 9 participants (Actual) | Observational | 2015-01-31 | Completed | |||
| Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness in Patients With Hemorrhagic Stroke: A Pilot Study[NCT04427241] | Phase 4 | 12 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | ||
| Safety and Efficacy of Transcranial Direct Current Stimulation in Pediatric Disorders of Consciousness[NCT05929274] | 10 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | |||
| The Impact and Outcomes of Combined Cerebrolysin and Amantadine Sulfate Administration on Management of Patients With Traumatic Brain Injury in the ICU[NCT06052787] | Phase 3 | 150 participants (Anticipated) | Interventional | 2023-09-01 | Recruiting | ||
| A Multicenter Prospective Randomized Controlled Trial of the Effectiveness of Amantadine Hydrochloride in Promoting Recovery of Function Following Severe Traumatic Brain Injury[NCT00970944] | Phase 2/Phase 3 | 184 participants (Actual) | Interventional | 2003-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Measure of function after traumatic brain injury (TBI) intended to measure function from coma to community. Minimum score= 0; Maximum score= 29 (High scores are indicative of greater degree of disability)." (NCT00970944)
Timeframe: Randomization and weekly for 6 weeks. The primary study endpoint was week 4 and drug washout was week 6.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Week 4 (Primary endpoint) | Week 6 (Drug washout) | |
| Amantadine | 17.3 | 17.1 |
| Placebo | 18.7 | 17.8 |
"Measure of neurobehavioral function and clinical change for individuals with severe alterations of consciousness.~Minimum score= 0; Maximum score= 23 (Higher scores are indicative of a higher-level of neurobehavioral function)." (NCT00970944)
Timeframe: Week 4 (primary endpoint); Week 6 (post-washout)
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Week 4 (Primary endpoint) | Week 6 (Post-washout) | |
| Amantadine | 15.8 | 15.7 |
| Placebo | 14.2 | 15.1 |
1 review available for amantadine and Coma, Post-Concussive
| Article | Year |
|---|---|
Acute management of acquired brain injury Part III: an evidence-based review of interventions used to promote arousal from coma.
Topics: Amantadine; Arousal; Brain Injuries; Bromocriptine; Coma, Post-Head Injury; Dopamine Agonists; Evide | 2010 |
1 trial available for amantadine and Coma, Post-Concussive
| Article | Year |
|---|---|
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
3 other studies available for amantadine and Coma, Post-Concussive
| Article | Year |
|---|---|
Amantadine for severe traumatic brain injury.
Topics: Amantadine; Brain Injuries; Coma, Post-Head Injury; Dopamine Agents; Female; Humans; Male | 2012 |
Amantadine for severe traumatic brain injury.
Topics: Amantadine; Brain Injuries; Coma, Post-Head Injury; Dopamine Agents; Female; Humans; Male | 2012 |
Amantadine to enhance readiness for rehabilitation following severe traumatic brain injury.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amantadine; Brain Injuries; Cohort Studies; Coma, Post-H | 2005 |