Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
adenine | | 6-aminopurines; purine nucleobase | Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
phosphonoacetic acid | | monocarboxylic acid; phosphonic acids | antiviral agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
cytosine | | aminopyrimidine; pyrimidine nucleobase; pyrimidone | Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
thymine | | pyrimidine nucleobase; pyrimidone | Escherichia coli metabolite; human metabolite; mouse metabolite | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
uracil | | pyrimidine nucleobase; pyrimidone | allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
1,10-phenanthroline | | phenanthroline | EC 2.7.1.1 (hexokinase) inhibitor; EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
ag-1549 | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
foscarnet | | carboxylic acid; one-carbon compound; phosphonic acids | antiviral drug; geroprotector; HIV-1 reverse transcriptase inhibitor; sodium-dependent Pi-transporter inhibitor | 1992 | 2004 | 26.0 | low | 0 | 0 | 2 | 2 | 0 | 0 |
gentamicin | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
nevirapine | | cyclopropanes; dipyridodiazepine | antiviral drug; HIV-1 reverse transcriptase inhibitor | 1994 | 2004 | 25.5 | low | 0 | 0 | 2 | 2 | 0 | 0 |
thymidine | | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite | 1994 | 2001 | 27.0 | low | 0 | 0 | 2 | 1 | 0 | 0 |
alanine | | alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid | EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
aspartic acid | | aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid | Escherichia coli metabolite; mouse metabolite; neurotransmitter | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
glutamine | | amino acid zwitterion; glutamine family amino acid; glutamine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid | EC 1.14.13.39 (nitric oxide synthase) inhibitor; Escherichia coli metabolite; human metabolite; metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
lysine | | aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid | algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
adenosine diphosphate | | adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate | fundamental metabolite; human metabolite | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
uridine | | uridines | drug metabolite; fundamental metabolite; human metabolite | 1994 | 2001 | 26.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
tyrosine | | amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine | EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical | 1994 | 2001 | 26.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
adenosine monophosphate | | adenosine 5'-phosphate; purine ribonucleoside 5'-monophosphate | adenosine A1 receptor agonist; cofactor; EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.11 (fructose-bisphosphatase) inhibitor; fundamental metabolite; micronutrient; nutraceutical | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
phenylalanine | | amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid | algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
tryptophan | | erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan | antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
benzoxazoles | | 1,3-benzoxazoles; mancude organic heterobicyclic parent | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
dideoxyadenosine | | adenosines; purine 2',3'-dideoxyribonucleoside | EC 3.5.4.4 (adenosine deaminase) inhibitor; EC 4.6.1.1 (adenylate cyclase) inhibitor | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
vidarabine | | beta-D-arabinoside; purine nucleoside | antineoplastic agent; bacterial metabolite; nucleoside antibiotic | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
manganese | | elemental manganese; manganese group element atom | Escherichia coli metabolite; micronutrient | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
zalcitabine | | pyrimidine 2',3'-dideoxyribonucleoside | antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
glutamic acid | | glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid | Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical | 1992 | 2001 | 27.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
zidovudine | | azide; pyrimidine 2',3'-dideoxyribonucleoside | antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor | 1988 | 2015 | 29.2 | low | 0 | 2 | 5 | 0 | 1 | 0 |
paclitaxel | | taxane diterpenoid; tetracyclic diterpenoid | antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
thymidine 5'-triphosphate | | pyrimidine 2'-deoxyribonucleoside 5'-triphosphate; thymidine phosphate | Escherichia coli metabolite; mouse metabolite | 1991 | 1997 | 30.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
2,6-diaminopurine 2',3'-dideoxyriboside | | | | 1996 | 1996 | 28.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine | | aryl sulfide; primary alcohol; pyrimidone | antiviral drug; HIV-1 reverse transcriptase inhibitor | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil | | | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
l-697661 | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
tsao-t | | | | 1994 | 2001 | 26.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
1-(2',5'-bis-o-(tert-butyldimethylsilylribofuranosyl)-3-n-methylthymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) | | | | 1996 | 2001 | 25.5 | medium | 0 | 0 | 1 | 1 | 0 | 0 |
5-methylcytosine | | methylcytosine; pyrimidines | human metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
2',3'-dideoxythymidine triphosphate | | pyrimidine 2',3'-dideoxyribonucleoside 5'-triphosphate; thymidine phosphate | | 1988 | 2001 | 29.8 | high | 0 | 2 | 9 | 1 | 0 | 0 |
2',3'-dideoxyadenosine triphosphate | | purine deoxyribonucleoside triphosphate | | 1990 | 2006 | 26.0 | high | 0 | 0 | 6 | 3 | 0 | 0 |
1,7-phenanthroline | | phenanthroline | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
6-methyladenine | | 6-alkylaminopurine; methyladenine | human metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
zidovudine triphosphate | | | | 1988 | 2015 | 27.4 | low | 0 | 1 | 3 | 0 | 1 | 0 |
2',3'-dideoxycytidine 5'-triphosphate | | | | 1990 | 2001 | 28.5 | medium | 0 | 0 | 3 | 1 | 0 | 0 |
n(4)-methylcytosine | | aminopyrimidine; methylcytosine; pyrimidone | metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
r 82150 | | | | 1992 | 1996 | 30.0 | medium | 0 | 0 | 3 | 0 | 0 | 0 |
r-82913 | | | | 1992 | 1994 | 30.7 | low | 0 | 0 | 3 | 0 | 0 | 0 |
uc-781 | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
sulfur | | chalcogen; nonmetal atom | macronutrient | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
ribose | | D-ribose; ribopyranose | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
nad | | organophosphate oxoanion | cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
oligonucleotides | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
deoxyguanosine triphosphate | | deoxyguanosine phosphate; guanyl deoxyribonucleotide; purine 2'-deoxyribonucleoside 5'-triphosphate | Arabidopsis thaliana metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite | 1981 | 1997 | 34.3 | low | 0 | 1 | 2 | 0 | 0 | 0 |
guanosine diphosphate | | guanosine 5'-phosphate; purine ribonucleoside 5'-diphosphate | Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor | 1981 | 1995 | 37.3 | low | 0 | 2 | 1 | 0 | 0 | 0 |
guanosine triphosphate | | guanosine 5'-phosphate; purine ribonucleoside 5'-triphosphate | Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor | 1981 | 1995 | 36.7 | low | 0 | 4 | 2 | 0 | 0 | 0 |
nsc 614846 | | carbovir | HIV-1 reverse transcriptase inhibitor | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
guanosine 5'-(alpha,beta-methylene)triphosphate | | | | 1995 | 1995 | 29.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
carbovir triphosphate | | organic triphosphate | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
9-beta-d-arabinofuranosylguanosine 5'-triphosphate | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |