Compounds > 3'-azido-2',3'-dideoxyguanosine
Page last updated: 2024-08-04 04:37:31

3'-azido-2',3'-dideoxyguanosine

Description

Cross-References

ID SourceID
PubMed CID135433653
CHEMBL ID578448
SCHEMBL ID15643042
MeSH IDM0145526

Synonyms (17)

Synonym
guanosine, 3'-azido-2',3'-dideoxy-
3'-azido-ddg
2-amino-9-[(2r,4s,5s)-4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1h-purin-6-one
azddguo
3'-azido-2',3'-dideoxyguanosine
66323-46-4
3'-n3ddg
CHEMBL578448
rfs-457
2-amino-9-[(2s,5r)-4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl]purin-6-ol
3'-azido-2'-3'-dideoxyguanosine
SCHEMBL15643042
2-amino-9-((2r,4s,5s)-4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1h-purin-6(9h)-one
3'-azido-2'-deoxyguanosine
2-amino-9-[(2r,4s,5s)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-1h-purin-6-one
2-amino-9-((2r,4s,5s)-4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6h-purin-6-one
A855657

Bioassays (53)

Assay IDTitleYearJournalArticle
AID572993Mitochondrial toxicity in human HepG2 cells assessed as percent mitochondrial DNA production at 10 uM after 14 days by real-time PCR relative to control2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID452271Cytotoxicity against human CEM cells after 5 days2010Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
ISSN: 1464-3405		Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus.
AID436401Cytotoxicity against human PBMC cells2009European journal of medicinal chemistry, Oct, Volume: 44, Issue:10
ISSN: 1768-3254		Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.
AID572986Cytotoxicity against human PBMC at < 50 to 100 uM after 2 to 4 days by MTT assay2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572775Antiviral activity against HIV1 harboring reverse transcriptase L74V mutant infected in human HeLa P4/R5 cells assessed as inhibition of viral replication2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572780Ratio of IC50 for HIV1 harboring reverse transcriptase M184V mutant infected in human HeLa P4/R5 cells to wild type HIV1 infected in human HeLa P4/R5 cells2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572784Antiviral activity against HIV1 harboring reverse transcriptase D67N/K70R/T215F/K219Q mutant infected in human HeLa P4/R5 cells assessed as inhibition of viral replication2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID452269Antiviral activity against HIV1 LAI infected in human PBM cells after 5 days2010Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
ISSN: 1464-3405		Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus.
AID572982Cytotoxicity against human MT2 cells after 2 to 4 days by MTT assay2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572981Cytotoxicity against human PBMC after 2 to 4 days by MTT assay2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID515880Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by SYBR green assay2010Bioorganic & medicinal chemistry, Oct-15, Volume: 18, Issue:20
ISSN: 1464-3391		Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.
AID572998Mitochondrial toxicity in human HepG2 cells assessed as percent inhibition of beta-actin DNA at 100 uM after 14 days by real-time PCR2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572987Cytotoxicity against human MT2 cells at < 50 to 100 uM after 2 to 4 days by MTT assay2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572785Antiviral activity against HIV1 harboring reverse transcriptase M41L/D67N/K70R/L210W/T215Y/K219Q mutant infected in human HeLa P4/R5 cells assessed as inhibition of viral replication2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572972Antiviral activity against HIV1 harboring reverse transcriptase diserine insert between residues 69 and 70 infected in human HeLa P4/R5 cells assessed as inhibition of viral replication2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572782Antiviral activity against HIV1 harboring reverse transcriptase M41L/L210W/T215Y mutant infected in human HeLa P4/R5 cells assessed as inhibition of viral replication2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572776Antiviral activity against HIV1 harboring reverse transcriptase M184V mutant infected in human HeLa P4/R5 cells assessed as inhibition of viral replication2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572974Ratio of IC50 for HIV1 harboring reverse transcriptase M41L/D67N/K70R/T215F/K219Q mutant infected in human HeLa P4/R5 cells to wild type HIV1 infected in human HeLa P4/R5 cells2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572976Ratio of IC50 for HIV1 harboring reverse transcriptase M41L/D67N/K70R/L210W/T215Y/K219Q mutant infected in human HeLa P4/R5 cells to wild type HIV1 infected in human HeLa P4/R5 cells2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572990Cytotoxicity against human HeLa P4/R5 cells at < 50 to 100 uM after 2 to 4 hrs by MTT assay2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID436403Cytotoxicity against african green monkey Vero cells2009European journal of medicinal chemistry, Oct, Volume: 44, Issue:10
ISSN: 1768-3254		Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.
AID572992Mitochondrial toxicity in human HepG2 cells assessed as percent inhibition of mitochondrial DNA at 100 uM after 14 days by real-time PCR2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572781Ratio of IC50 for HIV1 harboring reverse transcriptase Q151M mutant infected in human HeLa P4/R5 cells to wild type HIV1 infected in human HeLa P4/R5 cells2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572973Ratio of IC50 for HIV1 harboring reverse transcriptase M41L/L210W/T215Y mutant infected in human HeLa P4/R5 cells to wild type HIV1 infected in human HeLa P4/R5 cells2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572777Antiviral activity against HIV1 harboring reverse transcriptase Q151M mutant infected in human HeLa P4/R5 cells assessed as inhibition of viral replication2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572774Antiviral activity against HIV1 harboring reverse transcriptase K65R mutant infected in human HeLa P4/R5 cells assessed as inhibition of viral replication2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572779Ratio of IC50 for HIV1 harboring reverse transcriptase L74V mutant infected in human HeLa P4/R5 cells to wild type HIV1 infected in human HeLa P4/R5 cells2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID515879Antimalarial activity against Plasmodium falciparum 3D7 at 100 uM by SYBR green assay2010Bioorganic & medicinal chemistry, Oct-15, Volume: 18, Issue:20
ISSN: 1464-3391		Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.
AID572783Antiviral activity against HIV1 harboring reverse transcriptase M41L/D67N/K70R/T215F/K219Q mutant infected in human HeLa P4/R5 cells assessed as inhibition of viral replication2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572768Antiviral activity against HIV1 infected in human MT2 cells assessed as inhibition of viral replication2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572994Mitochondrial toxicity in human HepG2 cells assessed as percent mitochondrial DNA production at 100 uM after 14 days by real-time PCR relative to control2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572767Antiviral activity against HIV1 infected in human HeLa P4/R5 cells assessed as inhibition of viral replication2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID452270Cytotoxicity against human PBMC after 5 days2010Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
ISSN: 1464-3405		Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus.
AID572778Ratio of IC50 for HIV1 harboring reverse transcriptase K65R mutant infected in human HeLa P4/R5 cells to wild type HIV1 infected in human HeLa P4/R5 cells2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID452272Cytotoxicity against african green monkey Vero cells after 5 days2010Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
ISSN: 1464-3405		Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus.
AID572995Mitochondrial toxicity in human HepG2 cells assessed as percent lactic acid production at 10 uM after 14 days by real-time PCR relative to beta-actin DNA2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID436399Antiviral activity against HIV in human PBM cells by RNA replicon assay2009European journal of medicinal chemistry, Oct, Volume: 44, Issue:10
ISSN: 1768-3254		Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.
AID572999Antiviral activity against HIV1 LAI infected in human MT2 cells assessed as inhibition of viral replication selected after 65 passages relative to wild type HIV1 LAI2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572991Mitochondrial toxicity in human HepG2 cells assessed as percent inhibition of mitochondrial DNA at 10 uM after 14 days by real-time PCR2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID436400Antiviral activity against HCV in human Huh7 cells by RNA replicon assay2009European journal of medicinal chemistry, Oct, Volume: 44, Issue:10
ISSN: 1768-3254		Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.
AID572996Mitochondrial toxicity in human HepG2 cells assessed as percent lactic acid production at 100 uM after 14 days by real-time PCR relative to beta-actin DNA2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572769Antiviral activity against HIV1 infected in human PBMC assessed as inhibition of viral replication2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572988Cytotoxicity against african green monkey Vero cells at < 50 to 100 uM after 2 to 4 days by MTT assay2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572997Mitochondrial toxicity in human HepG2 cells assessed as percent inhibition of beta-actin DNA at 10 uM after 14 days by real-time PCR2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572978Cellular uptake in PHA-stimulated human PBMC assessed as accumulation of 3'-Azido-ddGTP after 12 hrs by LC-MS analysis2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572977Ratio of IC50 for HIV1 harboring reverse transcriptase diserine insert between residues 69 and 70 infected in human HeLa P4/R5 cells to wild type HIV1 infected in human HeLa P4/R5 cells2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572983Cytotoxicity against african green monkey Vero cells after 2 to 4 days by MTT assay2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572985Cytotoxicity against human HeLa P4/R5 cells after 2 to 4 hrs by MTT assay2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572979Drug level in PHA-stimulated human PBMC measured per 10'6 cells at 10 uM after 12 hrs by LC-MS analysis2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572984Cytotoxicity against human CEM cells after 2 to 4 days by MTT assay2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572975Ratio of IC50 for HIV1 harboring reverse transcriptase D67N/K70R/T215F/K219Q mutant infected in human HeLa P4/R5 cells to wild type HIV1 infected in human HeLa P4/R5 cells2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID436402Cytotoxicity against human CEM cells2009European journal of medicinal chemistry, Oct, Volume: 44, Issue:10
ISSN: 1768-3254		Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.
AID572989Cytotoxicity against human CEM cells at < 50 to 100 uM after 2 to 4 days by MTT assay2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
ISSN: 1098-6596		Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (11.76)18.7374
1990's2 (11.76)18.2507
2000's8 (47.06)29.6817
2010's5 (29.41)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
2'-deoxyadenosine triphosphate
1
2'-deoxyadenosine 5'-phosphate;
purine 2'-deoxyribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite		2009200915.0low000100
stavudine
1
dihydrofuran;
nucleoside analogue;
organic molecular entity		antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor		2009200915.0low000100
zalcitabine
1
pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor		2009200915.0low000100
zidovudine
3
azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor		2009201014.3low000300
3'-azido-2',3'-dideoxyuridine
1
2010201014.0medium000100
lamivudine
1
monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug		2009200915.0low000100
emtricitabine
1
monothioacetal;
nucleoside analogue;
organofluorine compound;
pyrimidone		antiviral drug;
HIV-1 reverse transcriptase inhibitor		2009200915.0low000100
thymidine 5'-triphosphate
1
pyrimidine 2'-deoxyribonucleoside 5'-triphosphate;
thymidine phosphate		Escherichia coli metabolite;
mouse metabolite		2009200915.0low000100
2'-deoxycytidine 5'-triphosphate
1
2'-deoxycytidine phosphate;
pyrimidine 2'-deoxyribonucleoside 5'-triphosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite		2009200915.0low000100
2',3'-didehydro-2',3'-dideoxyuridine
1
2010201014.0low000100
2',3'-dideoxyadenosine triphosphate
1
purine deoxyribonucleoside triphosphate2009200915.0low000100
stavudine triphosphate
1
2009200915.0low000100
3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside
1
2010201014.0medium000100
zidovudine triphosphate
1
2009200915.0low000100
2',3'-dideoxycytidine 5'-triphosphate
1
2009200915.0low000100
3'-azido-2',3'-dideoxyadenosine
2
2009201014.5high000200
lamivudine triphosphate
1
2009200915.0low000100
tenofovir diphosphate
1
2009200915.0low000100
tenofovir disoproxil fumarate
1
fumarate saltantiviral drug;
HIV-1 reverse transcriptase inhibitor;
prodrug		2009200915.0low000100
deoxyguanosine triphosphate
1
deoxyguanosine phosphate;
guanyl deoxyribonucleotide;
purine 2'-deoxyribonucleoside 5'-triphosphate		Arabidopsis thaliana metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite		2009200915.0low000100
didanosine
1
purine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor;
geroprotector;
HIV-1 reverse transcriptase inhibitor		2009200915.0low000100
2-aminopurine dioxolane
1
2009200915.0low000100
nsc 614846
1
carbovirHIV-1 reverse transcriptase inhibitor2009200915.0low000100
carbovir triphosphate
1
organic triphosphate2009200915.0low000100
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
purine
1
purine1995199529.0low001000
hydroxyurea
1
one-carbon compound;
ureas		antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent		1990199034.0low001000
thymidine
1
pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite		1995199529.0low001000
cytarabine
1
beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent		2005200519.0low000100
dideoxyadenosine
2
adenosines;
purine 2',3'-dideoxyribonucleoside		EC 3.5.4.4 (adenosine deaminase) inhibitor;
EC 4.6.1.1 (adenylate cyclase) inhibitor		2007201115.0low000110
zalcitabine
1
pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor		2011201113.0low000010
azides
1
pseudohalide anionmitochondrial respiratory-chain inhibitor2011201113.0low000010
zidovudine
3
azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor		1995201119.7low001110
adenosine
1
adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent		2012201212.0low000010
3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside
1
2007200717.0medium000100
3'-azido-2',3'-dideoxyadenosine
1
2011201113.0medium000010
3'-azido-2',3'-dideoxycytidine
1
2011201113.0medium000010
deoxyguanosine
2
purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite		1987198737.0low020000
guanosine
1
guanosines;
purines D-ribonucleoside		fundamental metabolite1995199529.0low001000
triacetylguanosine
1
1995199529.0medium001000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Acute Lymphoid Leukemia0
1
1990199034.0medium001000
Cell Transformation, Viral0
1
1987198737.0medium010000
HIV0
2
1987200926.0high010100
HIV Coinfection0
1
2009200915.0medium000100
HIV Infections0
1
2009200915.0medium000100
Precursor Cell Lymphoblastic Leukemia-Lymphoma0
1
1990199034.0medium001000

Safety/Toxicity (1)

ArticleYear
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Antimicrobial agents and chemotherapy, , Volume: 53, Issue:9		2009