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2',3'-dideoxyadenosine triphosphate and didanosine

2',3'-dideoxyadenosine triphosphate has been researched along with didanosine in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19902 (12.50)18.7374
1990's7 (43.75)18.2507
2000's4 (25.00)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
abu Sheikha, G; Cappellacci, L; de Montis, A; Franchetti, P; Grifantini, M; La Colla, P; Loi, AG; Messini, L; Spiga, MG; Tramontano, E1
Amblard, F; Bassit, L; Bondada, L; Coats, SJ; Detorio, M; Grier, J; Hernandez-Santiago, BI; Koontz, D; Mellors, JW; Rapp, KL; Schinazi, RF; Sluis-Cremer, N1
Nair, V; Sells, TB1
Fridland, A; Johnson, MA1
Ahluwalia, G; Broder, S; Cooney, DA; Dalal, M; Flora, KP; Fridland, A; Hao, Z; Johns, DG; Mitsuya, H1
Balzarini, J; Eschbach, A; Halazy, S; Navé, JF; Wolff-Kugel, D1
López, M; Mayol, N; Vázquez-Padua, MA1
Boyer, PL; Hughes, SH; Lisziewicz, J; Lori, F1
Beuneu, C; Buc, H; Lemaire, G; Lepoivre, M; Roux, P; Roy, B1
Back, DJ; Barry, MG; Henry-Mowatt, JS; Hoggard, PG; Kewn, S; Sales, SD; Veal, GJ1
Agrofoglio, LA; Cahours, X; Kieda, C; Mesplet, N; Morin, P; Tran, TT1
Cupo, A; Dellamonica, P; Durant, J; Duval, D; Ettesse, H; Guedj, R; Le Saint, C; Terreux, R; Vincent, JP1
Boretto, J; Canard, B; Courcambeck, J; Deval, J; Garrido-Urbani, S; Halfon, P; Navarro, JM; Selmi, B; Sire, J1
Babusis, D; Durand-Gasselin, L; Flaherty, JF; Hawkins, T; Ray, AS; Reddy, YS; Veikley, W1
Baev, D; Cahn, P; Calarota, SA; De Forni, D; Katabira, E; Lori, F; Maserati, R; Rakhmanova, A; Stevens, MR; Testori, M1
Gang, L; Huilin, G; Lan, X; Lvjiang, H; Mingdao, L; Wei, G; Yan, Z1

Trials

2 trial(s) available for 2',3'-dideoxyadenosine triphosphate and didanosine

ArticleYear
Intracellular nucleotide levels during coadministration of tenofovir disoproxil fumarate and didanosine in HIV-1-infected patients.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:4

    Topics: Adenine; Adult; Aged; Anti-HIV Agents; Chromatography, Liquid; Deoxyadenine Nucleotides; Deoxyguanine Nucleotides; Didanosine; Dideoxynucleotides; Female; HIV Infections; Humans; Male; Middle Aged; Nucleotides; Organophosphonates; Tandem Mass Spectrometry; Tenofovir; Young Adult

2011
VS411 reduced immune activation and HIV-1 RNA levels in 28 days: randomized proof-of-concept study for antiviral-hyperactivation limiting therapeutics.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Adult; Analysis of Variance; Anti-HIV Agents; Biomarkers; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Delayed-Action Preparations; Deoxyadenine Nucleotides; Didanosine; Dideoxynucleotides; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; HIV Infections; HIV-1; Humans; Immunomodulation; Male; Placebos; RNA, Viral; Urea; Viral Load

2012

Other Studies

14 other study(ies) available for 2',3'-dideoxyadenosine triphosphate and didanosine

ArticleYear
Synthesis and evaluation of the anti-HIV activity of aza and deaza analogues of isoddA and their phosphates as prodrugs.
    Journal of medicinal chemistry, 1994, Oct-14, Volume: 37, Issue:21

    Topics: Adenosine Triphosphate; Antiviral Agents; Aza Compounds; Dideoxyadenosine; Dideoxynucleotides; HIV Reverse Transcriptase; HIV-1; HIV-2; Molecular Structure; Phosphates; Recombinant Proteins; Reverse Transcriptase Inhibitors

1994
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9

    Topics: Anti-HIV Agents; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dideoxynucleosides; HIV Infections; HIV-1; Humans; Molecular Structure; Reverse Transcriptase Inhibitors

2009
Interpretation of the roles of adenylosuccinate lyase and of AMP deaminase in the anti-HIV activity of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine.
    Biochimica et biophysica acta, 1992, Feb-26, Volume: 1119, Issue:2

    Topics: Adenosine; Adenylosuccinate Lyase; AMP Deaminase; Deoxyadenine Nucleotides; Didanosine; Dideoxyadenosine; Dideoxynucleotides; HIV; Succinates

1992
Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells.
    Molecular pharmacology, 1989, Volume: 36, Issue:2

    Topics: 5'-Nucleotidase; Adenosine Triphosphate; Deoxyadenine Nucleotides; Didanosine; Dideoxynucleosides; Dideoxynucleotides; Dinucleoside Phosphates; Humans; In Vitro Techniques; Inosine Monophosphate; Kinetics; Nucleotidases; Phosphorylation; T-Lymphocytes

1989
Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity.
    Biochemical pharmacology, 1987, Nov-15, Volume: 36, Issue:22

    Topics: Alanine; Animals; Cell Line; Chromatography, High Pressure Liquid; Deoxyadenine Nucleotides; Deoxyribonucleotides; Didanosine; Dideoxynucleotides; HIV; Inosine; Nucleotides; T-Lymphocytes

1987
Enzymatic phosphorylation and pyrophosphorylation of 2',3'-dideoxyadenosine-5'-monophosphate, a key metabolite in the pathway for activation of the anti-HIV (human immunodeficiency virus) agent 2',3'-dideoxyinosine.
    Biochemical pharmacology, 1994, Sep-15, Volume: 48, Issue:6

    Topics: Adenosine Triphosphate; Adenylate Kinase; Animals; Biotransformation; Deoxyadenine Nucleotides; Didanosine; Dideoxynucleotides; Escherichia coli; HIV; Kinetics; Phosphorylation; Rats; Ribose-Phosphate Pyrophosphokinase; Substrate Specificity

1994
Uptake and distribution of 2',3'-dideoxyinosine and its derivatives in a human monocytoid cell line.
    Cellular and molecular biology (Noisy-le-Grand, France), 1995, Volume: 41 Suppl 1

    Topics: Biological Transport; Biotransformation; Cell Division; Deoxyadenine Nucleotides; Didanosine; Dideoxynucleotides; DNA Damage; DNA Replication; DNA, Neoplasm; Humans; Lymphoma, Large B-Cell, Diffuse; Monocytes; RNA, Neoplasm; Tumor Cells, Cultured; Zidovudine

1995
Analysis of amino insertion mutations in the fingers subdomain of HIV-1 reverse transcriptase.
    Journal of molecular biology, 1999, Mar-05, Volume: 286, Issue:4

    Topics: Anti-HIV Agents; Deoxyadenine Nucleotides; Didanosine; Dideoxynucleotides; Drug Resistance, Microbial; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Mutagenesis, Insertional; Protein Conformation

1999
Simultaneous determination of pyrimidine or purine deoxyribonucleoside triphosphates using a polymerase assay.
    Analytical biochemistry, 1999, May-01, Volume: 269, Issue:2

    Topics: Anti-HIV Agents; Base Sequence; Cell Line; Chromatography, High Pressure Liquid; Deoxyadenine Nucleotides; Deoxyribonucleotides; Didanosine; Dideoxynucleotides; DNA Polymerase I; DNA Primers; Humans; Lymphocytes; Sensitivity and Specificity

1999
Intracellular activation of 2',3'-dideoxyinosine and drug interactions in vitro.
    AIDS research and human retroviruses, 1999, Jun-10, Volume: 15, Issue:9

    Topics: Anti-HIV Agents; Deoxyadenine Nucleotides; Didanosine; Dideoxynucleotides; Drug Interactions; Guanosine; Humans; Hydroxyurea; Inosine; Intracellular Fluid; Lamivudine; Pentoxifylline; Stavudine; U937 Cells; Zidovudine

1999
Analysis of intracellular didanosine triphosphate at sub-ppb level using LC-MS/MS.
    Journal of pharmaceutical and biomedical analysis, 2001, Volume: 26, Issue:5-6

    Topics: Cells, Cultured; Chromatography, Liquid; Deoxyadenine Nucleotides; Didanosine; Dideoxynucleotides; Humans; Radioimmunoassay; Reproducibility of Results; Solutions; Spectrometry, Mass, Electrospray Ionization

2001
Determination of ddATP levels in human immunodeficiency virus-infected patients treated with dideoxyinosine.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:2

    Topics: Anti-HIV Agents; Antibodies; Biotransformation; Chromatography, Ion Exchange; Deoxyadenine Nucleotides; Didanosine; Dideoxynucleotides; HIV Infections; Humans; Hydrolysis; In Vitro Techniques; Leukocyte Count; Models, Molecular; Neutrophils; Phosphorylation; Radioimmunoassay

2004
A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions.
    The Journal of biological chemistry, 2004, Jun-11, Volume: 279, Issue:24

    Topics: Cells, Cultured; Deoxyadenine Nucleotides; Didanosine; Dideoxynucleotides; DNA Replication; Drug Resistance, Viral; HIV Reverse Transcriptase; Humans; Kinetics; Mutation; Virus Replication

2004
Simultaneous determination of 2',3'-dideoxyinosine and the active metabolite, 2',3'-dideoxyadenosine-5'-triphosphate in human peripheral-blood mononuclear cell by HPLC-MS/MS and the application to cell pharmacokinetics.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015, Oct-01, Volume: 1002

    Topics: Adult; Anti-HIV Agents; Chromatography, High Pressure Liquid; Deoxyadenine Nucleotides; Didanosine; Dideoxynucleotides; HIV Infections; Humans; Limit of Detection; Middle Aged; Reproducibility of Results; Tandem Mass Spectrometry

2015