Compounds > stavudine triphosphate
Page last updated: 2024-09-23

stavudine triphosphate

Description

stavudine triphosphate: shows termination substrate properties in DNA synthesis catalyzed by several different DNA polymerases; also abbreviated d4TTP [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID65355
CHEMBL ID485652
SCHEMBL ID987898
MeSH IDM0150763

Synonyms (24)

Synonym
stavudine triphosphate
d4ttp
[hydroxy-[[(2s,5r)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate
26194-89-8
thymidine 5'-(tetrahydrogen triphosphate), 2',3'-didehydro-3'-deoxy-
thymine, 1-(2,3-dideoxy-.beta.-d-glycero-pent-2-enofuranosyl)-, 5'-(tetrahydrogen triphosphate)
ddettp
2',3'-didehydro-3'-deoxythymidine 5'-triphosphate
d4t-tp
2',3'-dideoxy-2',3'-dehydrothymidine 5'-triphosphate
DB02887
CHEMBL485652 ,
2,3-ddddttp
1zp0vj751g ,
2',3'-dedehydro-2',3'-dideoxythymidine triphosphate
unii-1zp0vj751g
dddttp
bdbm50370655
SCHEMBL987898
hymidine 5'-(tetrahydrogen triphosphate), 2',3'-didehydro-3'-deoxy-
DTXSID10180822
stavudine triphosphate triethylammonium salt
J-016315
Q27093852

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Reverse transcriptase/RNaseH Human immunodeficiency virus 1IC50 (µMol)4.47530.00011.076810.0000AID289142; AID405417; AID740628
Reverse transcriptase/RNaseH Human immunodeficiency virus 1Ki0.50290.00031.552310.0000AID238445; AID564144; AID564145; AID564146; AID564147; AID564148; AID564149; AID564150; AID564151
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Reverse transcriptase/RNaseH Human immunodeficiency virus 1Kd185.76000.00062.40599.8000AID529698; AID529699; AID529700; AID529701; AID572771
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (57)

Assay IDTitleYearJournalArticle
AID529729Selectivity index, ratio of Kpol/Kd for RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of dTMP to Kpol/Kd for RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase reverse transcriptase assess2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID529700Inhibition of DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase M184V mutant assessed as incorporation of d4TMP by burst assay using DNA/DNA Primer/Template combination2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID572772Ratio of Kpol to Kd for HIV1 reverse transcriptase2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID529698Inhibition of RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase M184V mutant assessed as incorporation of d4TMP by burst assay using RNA/DNA Primer/Template combination2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID83421The inhibition of compound was determined by reverse transcriptase assay using DNA as template1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.
AID405417Inhibition of HIV1 recombinant reverse transcriptase2007Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
AID564155Ratio of Ki to Km for HIV1 Reverse transcriptase M184V mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID564154Ratio of Ki to Km for HIV1 Reverse transcriptase T165A mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID564157Ratio of Ki to Km for HIV1 Reverse transcriptase P119S/M184V mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID1700728Antiviral activity against HIV2 ROD infected in human TK-deficient CEM/0 cells assessed as inhibition of viral-induced giant cell formation incubated for 4 to 5 days by microscopy2020Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22
γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs as Potential Antivirals.
AID564146Inhibition of HIV1 Reverse transcriptase T165A mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID529713Activity of RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of d4TMP by burst assay using RNA/DNA Primer/Template combination2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID83422The inhibition of compound was determined by reverse transcriptase assay using RNA as template1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.
AID529701Inhibition of DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of d4TMP by burst assay using DNA/DNA Primer/Template combination2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID405416Inhibition of PERV reverse transcriptase from Kagoshima pig DRK4 cells2007Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
AID1700727Antiviral activity against HIV2 ROD infected in human CEM/0 cells assessed as inhibition of virus-induced syncytia cell formation measured after 4 to 5 days by microscopic analysis2020Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22
γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs as Potential Antivirals.
AID564147Inhibition of HIV1 Reverse transcriptase M184V mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID1700726Antiviral activity against HIV1 3B infected in human CEM/0 cells assessed as inhibition of virus-induced syncytia cell formation measured after 4 to 5 days by microscopic analysis2020Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22
γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs as Potential Antivirals.
AID564156Ratio of Ki to Km for HIV1 Reverse transcriptase P119S/T165A mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID529710Activity of DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase M184V mutant assessed as incorporation of d4TMP by burst assay using DNA/DNA Primer/Template combination2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID405415Inhibition of PERV reverse transcriptase from Kagoshima pig KK5 cells2007Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
AID1655036Half life in pH 7.3 phosphate buffered saline by HPLC analysis
AID405414Inhibition of PERV reverse transcriptase from pig PK15 cells2007Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
AID564144Inhibition of wild-type HIV1 Reverse transcriptase2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID564148Inhibition of HIV1 Reverse transcriptase P119S/T165A mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID564151Inhibition of HIV1 Reverse transcriptase P119S/T165A/M184V mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID564159Ratio of Ki to Km for HIV1 Reverse transcriptase P119S/T165A/M184V mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID1700746Substrate activity at HIV reverse transcriptase assessed as increase in primer extension incubated at 37 degC for 60 mins and at 80 degC for 3 mins in presence of fluorescent-lebelled dATP, dCTP and dGTP by PAGE analysis2020Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22
γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs as Potential Antivirals.
AID529723Ratio of Kpol/Kd for DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of d4TMP by burst assay using DNA/DNA Primer/Template combination2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID289146Antiviral activity against HIV with reverse transcriptase M184V mutation assessed as reduction of potency relative to wild type2007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
AID564145Inhibition of HIV1 Reverse transcriptase P119S mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID564149Inhibition of HIV1 Reverse transcriptase P119S/M184V mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID529724Ratio of Kpol/Kd for RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase M184V mutant assessed as incorporation of d4TMP by burst assay using RNA/DNA Primer/Template combination2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID289143Cytotoxicity against MT2 cells2007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
AID1700729Cytotoxicity against human CEM/0 CD4+ T cells assessed as reduction in cell viability2020Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22
γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs as Potential Antivirals.
AID529711Activity of DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of d4TMP by burst assay using DNA/DNA Primer/Template combination2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID529727Selectivity index, ratio of Kpol/Kd for DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of dTMP to Kpol/Kd for DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase reverse transcriptase assess2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID238445Inhibitory constant against HIV-1 reverse transcriptase2005Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase.
AID572771Binding affinity to HIV1 reverse transcriptase2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID572764Selectivity, ratio of Kpol to Kd for TTP to Kpol to Kd for compound at HIV1 reverse transcriptase2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID564158Ratio of Ki to Km for HIV1 Reverse transcriptase T165A/M184V mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID289141Inhibition of virus-induced cytopathic effect in wild type HIV 3a infected MT2 cells after 5 days2007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
AID289144Antiviral activity against HIV1 with reverse transcriptase 6TAM mutation assessed as reduction of potency relative to wild type2007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
AID564150Inhibition of HIV1 Reverse transcriptase T165A/M184V mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID289145Antiviral activity against HIV1 with reverse transcriptase K65R mutation assessed as reduction of potency relative to wild type2007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
AID529726Selectivity index, ratio of Kpol/Kd for DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase M184V mutant assessed as incorporation of dTMP to Kpol/Kd for DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase reverse transcr2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID564152Ratio of Ki to Km for wild-type HIV1 Reverse transcriptase2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
AID572770Activity at HIV1 reverse transcriptase measured after 30 mins2009Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
AID529728Selectivity index, ratio of Kpol/Kd for RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase M184V mutant assessed as incorporation of dTMP to Kpol/Kd for RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase reverse transcr2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID289142Inhibition of HIV1 reverse transcriptase2007Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
AID529699Inhibition of RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of d4TMP by burst assay using RNA/DNA Primer/Template combination2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID373568Ratio of Ki to Km for HIV1 reverse transcriptase2007Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.
AID529722Ratio of Kpol/Kd for DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase M184V mutant assessed as incorporation of d4TMP by burst assay using DNA/DNA Primer/Template combination2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID529725Ratio of Kpol/Kd for RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of d4TMP by burst assay using RNA/DNA Primer/Template combination2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID529712Activity of RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase M184V mutant assessed as incorporation of d4TMP by burst assay using RNA/DNA Primer/Template combination2008Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
AID740628Competitive inhibition of C-Terminal histidine-tagged wild type heterodimeric HIV-1 reverse transcriptase p66/p51 assessed as inhibition of dTTP incorporation after 15 mins by PAGE2013Journal of medicinal chemistry, May-23, Volume: 56, Issue:10
Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy.
AID564153Ratio of Ki to Km for HIV1 Reverse transcriptase P119S mutant2009Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (22.22)18.7374
1990's1 (5.56)18.2507
2000's10 (55.56)29.6817
2010's1 (5.56)24.3611
2020's2 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
stavudine[no description available]medium90dihydrofuran;
nucleoside analogue;
organic molecular entity		antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
zidovudine[no description available]medium80azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
2',3'-dideoxythymidine triphosphate[no description available]medium10pyrimidine 2',3'-dideoxyribonucleoside 5'-triphosphate;
thymidine phosphate
zidovudine triphosphate[no description available]medium40
zalcitabine[no description available]medium30pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
thymidine 5'-triphosphate[no description available]medium50pyrimidine 2'-deoxyribonucleoside 5'-triphosphate;
thymidine phosphate		Escherichia coli metabolite;
mouse metabolite
2',3'-dideoxyadenosine triphosphate[no description available]medium20purine deoxyribonucleoside triphosphate
2',3'-dideoxyuridine-5'-triphosphate[no description available]medium10
3'-fluorothymidine-5'-triphosphate[no description available]medium10
lamivudine triphosphate[no description available]medium20
nevirapine[no description available]medium20cyclopropanes;
dipyridodiazepine		antiviral drug;
HIV-1 reverse transcriptase inhibitor
adefovir[no description available]medium106-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent
lamivudine[no description available]medium30monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
4'-azidothymidine[no description available]medium10
tenofovir[no description available]medium20nucleoside analogue;
phosphonic acids		antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor
6-phosphonylmethoxyethoxy-2,4-diaminopyrimidine[no description available]medium10
2',3'-didehydro-3'-deoxy-4'-ethynylthymidine[no description available]medium20
2',3'-dideoxythymidine[no description available]medium10
tenofovir disoproxil fumarate[no description available]medium20fumarate saltantiviral drug;
HIV-1 reverse transcriptase inhibitor;
prodrug
2'-deoxyadenosine triphosphate[no description available]medium102'-deoxyadenosine 5'-phosphate;
purine 2'-deoxyribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite
emtricitabine[no description available]medium10monothioacetal;
nucleoside analogue;
organofluorine compound;
pyrimidone		antiviral drug;
HIV-1 reverse transcriptase inhibitor
2'-deoxycytidine 5'-triphosphate[no description available]medium102'-deoxycytidine phosphate;
pyrimidine 2'-deoxyribonucleoside 5'-triphosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
2',3'-dideoxycytidine 5'-triphosphate[no description available]medium10
3'-azido-2',3'-dideoxyadenosine[no description available]medium10
tenofovir diphosphate[no description available]medium10
deoxyguanosine triphosphate[no description available]medium10deoxyguanosine phosphate;
guanyl deoxyribonucleotide;
purine 2'-deoxyribonucleoside 5'-triphosphate		Arabidopsis thaliana metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
didanosine[no description available]medium10purine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor;
geroprotector;
HIV-1 reverse transcriptase inhibitor
3'-azido-2',3'-dideoxyguanosine[no description available]medium10
carbovir triphosphate[no description available]medium10organic triphosphate
4-hydroxybenzyl alcohol[no description available]medium10benzyl alcohols;
phenols		plant metabolite
arabinofuranosyluracil[no description available]medium10
thymidine[no description available]medium10pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
2'-fluorothymidine[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
HIV0low50
HIV Coinfection0low10
HIV Infections0low10
HTLV-III Infections0low10
HTLV-III-LAV Infections0low10
T-Lymphotropic Virus Type III Infections, Human0low10

Research Highlights

Safety/Toxicity (1)

ArticleYear
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Antimicrobial agents and chemotherapy, Volume: 53, Issue: 9		2009
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

ArticleYear
Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.
Antimicrobial agents and chemotherapy, Volume: 51, Issue: 11		2007
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]