2',3'-dideoxyuridine-5'-triphosphate: inhibits HIV reverse transcriptase & has potent DNA chain termination activity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 72245 |
| CHEMBL ID | 192371 |
| SCHEMBL ID | 661070 |
| MeSH ID | M0174188 |
| Synonym |
|---|
| 2',3'-dideoxyuridine-5'-triphosphate |
| ddutp |
| 84445-38-5 |
| [[(2s,5r)-5-(2,4-dioxopyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate |
| bdbm50164646 |
| [[[5-(2,4-dioxo-1h-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid |
| CHEMBL192371 , |
| [[(2s,5r)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate |
| A843479 |
| [[(2s,5r)-5-(2,4-dioxo-1-pyrimidinyl)-2-oxolanyl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate |
| uridine 5'-(tetrahydrogen triphosphate), 2',3'-dideoxy- |
| SCHEMBL661070 |
| dideoxyuridine-triphosphate |
| 2',3'-dideoxy-uridine-5'-triphosphate |
| OTXOHOIOFJSIFX-POYBYMJQSA-N |
| HY-155743 |
| CS-0885963 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | Ki | 0.5450 | 0.0003 | 1.5523 | 10.0000 | AID238445 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID237107 | Half-life determined in fetal calf serum | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7 | Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. |
| AID238445 | Inhibitory constant against HIV-1 reverse transcriptase | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7 | Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||